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Browsing Research Articles (Physiology) by Author "Mqoco, T.V. (Thandi Vuyelwa)"
Now showing items 1-19 of 19
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Mqoco, T.V. (Thandi Vuyelwa); Marais, Sumari; Joubert, Annie M. (Biomedical Research Press, 2013)2-Methoxyestradiol-bis-sulphamate (2-MeOE2bisMATE) is a bis-sulphamoylated analogue of a biological estradiol metabolite, 2-methoxyestradiol (2ME2) with potential as an anticancer drug. The aim of this in vitro study was ...
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Mqoco, T.V. (Thandi Vuyelwa); Marais, Sumari; Joubert, Annie M. (Suid Afrikaanse Akademie vir Wetenskap & Kuns, 2012)Future in vitro studies into the mechanism of this potentially anticancer drug are warranted.
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Mqoco, T.V. (Thandi Vuyelwa); Stander, Andre; Engelbrecht, Anna-Mart; Joubert, Annie M. (Hindawi Publishing, 2019-12-11)Current chemotherapeutic agents have many side effects and are toxic to normal cells, providing impetus to identify agents that can effectively eliminate tumorigenic cells without damaging healthy cells. The aim of this ...
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Mqoco, T.V. (Thandi Vuyelwa); Visagie, M.H. (Michelle Helen); Albrecht, C.; Joubert, Annie M. (Elsevier, 2014-01)Sutherlandia frutescens (SF) is a traditional Africanmedicinal aid employed for the treatment of various ailments such as inflammation, pulmonary asthma and congestion. The present study was conducted to demonstrate ...
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Soma, Prashilla; Swanepoel, A.C. (Albe Carina); Du Plooy, Jeanette Noel; Mqoco, T.V. (Thandi Vuyelwa); Pretorius, Etheresia (BioMed Central, 2016-03-31)BACKGROUND : The function of platelets have extended way beyond the horizon of haemostasis and thrombosis, and are recognised as active participants in vascular inflammation, as well as in prothrombotic complications of ...
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Nkandeu, D.S. (Danielle Sandra); Mqoco, T.V. (Thandi Vuyelwa); Visagie, M.H. (Michelle Helen); Stander, Barend Andre; Wolmarans, Elize; Cronje, Marianne J.; Joubert, Annie M. (Wiley, 2013-10)2-Methoxyestradiol, a natural metabolite of estradiol, exerts antiproliferative and antitumour properties in vitro and in vivo. Because of its low oral bioavailability, several promising analogues of 2-methoxyestradiol ...
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Marais, Sumari; Mqoco, T.V. (Thandi Vuyelwa); Stander, Andre; Van Papendorp, D.H. (Dirk Hermanus), 1949-; Joubert, Annie M. (Biomedical Research Press, 2012)2-Methoxyestradiol (2ME2) is an endogenous metabolite of estrogen that has both antiangiogenic and antitumor effects. However, the shortcoming with 2ME2 is that it is rapidly inactivated by 17β-hydroxysteroid dehydrogenase ...
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Marais, Sumari; Mqoco, T.V. (Thandi Vuyelwa); Stander, Barend Andre; Prudent, Renaud; Lafanechere, Laurence; Joubert, Annie M. (Suid Afrikaanse Akademie vir Wetenskap & Kuns, 2012)It can be concluded that compound-X induced both autophagy and apoptosis as a means of cell death in HeLa cells.
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Mqoco, T.V. (Thandi Vuyelwa); Marais, Sumari; Joubert, Annie M. (AOSIS Open Journals, 2013)Autophagy and apoptosis were induced and therefore suggests a link between two types of cell deaths induced by this compound.
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Nkandeu, Sandra; Mqoco, T.V. (Thandi Vuyelwa); Visagie, M.H. (Michelle Helen); Marais, Sumari; Stander, Barend A.; Joubert, Annie M. (Suid Afrikaanse Akademie vir Wetenskap & Kuns, 2012)After a 24 hour exposure time, cells both apoptosis and autophagy were induced.
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Influence of estradiol analogue on cell growth, morphology and death in esophageal carcinoma cells Mqoco, T.V. (Thandi Vuyelwa); Marais, Sumari; Joubert, Annie M. (Centro Regional de Investigaciones Cientificas Y Tecnologicas / Universidad Nacional de Cuyo, 2010)2-Methoxyestradiol-bis-sulphamate is a bis-sulphamoylated derivative of the naturally occurring 17-beta-estradiol metabolite namely 2-methoxyestradiol. 2-Methoxyestradiol-bis-sulphamate is regarded as a potential anticancer ...
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Visagie, M.H. (Michelle Helen); Mqoco, T.V. (Thandi Vuyelwa); Liebenberg, Leon; Mathews, Edward Henry; Mathews, George Edward; Joubert, Annie M. (BioMed Central, 2015-07-15)BACKGROUND : Due to their high proliferative requirements, tumorigenic cells possess altered metabolic systems whereby cells utilize higher quantities of glutamine and glucose. These altered metabolic requirements make ...
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Theron, Anne Elisabeth; Visagie, M.H. (Michelle Helen); Mqoco, T.V. (Thandi Vuyelwa); Stander, Andre; Prudent, Renaud; Lafanechere, Laurence; Joubert, Annie M. (Suid Afrikaanse Akademie vir Wetenskap & Kuns, 2012)Using a novel synthesised sulphamoylated 2-methoxyestradiol analogue, C19, two types of cell death, namely apoptosis and autophagy, were demonstrated in vitro when cervical cancer HeLa cells were exposed to this compound.
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Wolmarans, Elize; Mqoco, T.V. (Thandi Vuyelwa); Stander, Andre; Marais, Sumari; Joubert, Annie M. (Suid Afrikaanse Akademie vir Wetenskap & Kuns, 2012)Compound C19 was tested on the esophageal carcinoma SNO cell line. Results showed induction of apoptosis and autophagy induced by C19. This contributes towards understanding its action
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Wolmarans, Elize; Mqoco, T.V. (Thandi Vuyelwa); Stander, Andre; Nkandeu, Sandra; Sippel, Katherine H.; McKenna, Robert; Joubert, Annie M. (Springer, 2014-03)Cancer is the second leading cause of death in South Africa. The critical role that microtubules play in cell division makes them an ideal target for the development of chemotherapeutic drugs that prevent the hyperproliferation ...
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Steynberg, Tenille Jolene; Visagie, M.H. (Michelle Helen); Mqoco, T.V. (Thandi Vuyelwa); Idicula, Anu; Moolman, Sean; Richter, Wim; Joubert, Annie M. (Biomedical Research Press, 2012)Polycaprolactone (PCL) polymers which illustrate both biocompatibility and resorbability for replacement or bulking of damaged or diseased tissue are important in tissue engineering. Cytocompatibilty of these polymers ...
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Visagie, M.H. (Michelle Helen); Theron, Anne Elisabeth; Mqoco, T.V. (Thandi Vuyelwa); Vieira, Warren Antonio; Prudent, Renaud; Martinez, Anne; Lafanechere, Laurence; Joubert, Annie M. (Public Library of Science, 2013-09-05)2-Methoxyestradiol (2ME2) is a naturally occurring estradiol metabolite which possesses antiproliferative, antiangiogenic and antitumor properties. However, due to its limited biological accessibility, synthetic analogues ...
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Visagie, M.H. (Michelle Helen); Mqoco, T.V. (Thandi Vuyelwa); Joubert, Annie M. (Springer, 2012-12)Research into potential anticancer agents has shown that 2-methoxyestradiol exerts antiproliferative activity in vitro and in vivo in an estrogen receptor-independent manner. Due to its limited biological accessibility ...
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Repsold, Lisa; Mqoco, T.V. (Thandi Vuyelwa); Wolmarans, Elize; Nkandeu, Sandra; Theron, Joji; Piorkowski, Tomek; Du Toit, Peet J.; Van Papendorp, D.H. (Dirk Hermanus), 1949-; Joubert, Annie M. (BioMed Central, 2014-09)BACKGROUND : Novel, in silico-designed anticancer compounds were synthesized in our laboratory namely, 2-ethyl-3-Osulphamoyl- estra-1,3,5(10),15-tetraen-17-ol (ESE-15-ol) and 2-ethyl-3-O-sulphamoyl-estra-1,3,5(10)16-tetraene ...
Now showing items 1-19 of 19