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Browsing Research Articles (Physiology) by Author "Millar, Robert P."

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Continuous kisspeptin restores luteinizing hormone pulsatility following cessation by a neurokinin B antagonist in female sheep

Clarke, Iain J.; Li, Qun; Henry, Belinda A.; Millar, Robert P. (Oxford University Press, 2018-02)

Pulsatile secretion of the gonadotropin-releasing hormone (GnRH) drives pulsatile secretion of the luteinizing hormone (LH), with evidence that this depends on kisspeptin (Kiss) input to GnRH neurons. Kiss administration ...
Glu2.53(90) of the GnRH receptor is part of the conserved G protein-coupled receptor structure and does not form a salt-bridge with Lys3.32(121)

Manilall, Ashmeetha; Stander, Barend Andre; Madziva, Michael Taurai; Millar, Robert P.; Flanagan, Colleen A. (Elsevier, 2019-02)

Please read abstract in the article.
Hypothalamic-pituitary-ovarian axis reactivation by kisspeptin-10 in hyperprolactinemic women with chronic amenorrhea

Millar, Robert P.; Sonigo, Charlotte; Anderson, Richard A.; George, Jyothis; Maione, Luigi; Brailly-Tabard, Sylvie; Chanson, Philippe; Binart, Nadine; Young, Jacques (Endocrine Society, 2017-11)

CONTEXT : Hyperprolactinemia-induced hypogonadotropic amenorrhea (hPRL-HA) is a major cause of hypothalamic gonadotrophin-releasing hormone (GnRH) deficiency in women. In hyperprolactinemic mice, we previously demonstrated ...
Medial amygdala Kiss1 neurons mediate female pheromone stimulation of luteinizing hormone in male mice

Aggarwal, Sanya; Tang, Celion; Sing, Kristen; Kim, Hyun Wook; Millar, Robert P.; Tello, Javier A. (Karger, 2019)

BACKGROUND/AIMS : The medial amygdala (MeA) responds to olfactory stimuli and alters reproductive physiology. However, the neuronal circuit that relays signals from the MeA to the reproductive axis remains poorly defined. ...
Rescue of cell surface expression and signaling of mutant follicle-stimulating hormone receptors

Hanyroup, Sharika; Anderson, Ross Calley; Nataraja, Selvaraj; Yu, Henry N.; Millar, Robert P.; Newton, Claire L. (Oxford University Press, 2021-12)

Mutations in G protein-coupled receptors (GPCRs) underlie numerous diseases. Many cause receptor misfolding and failure to reach the cell surface. Pharmacological chaperones are cell-permeant small molecules that engage ...
Similarities and differences in the reproductive phenotypes of women with congenital hypogonadotrophic hypogonadism caused by GNRHR mutations and women with polycystic ovary syndrome

Maione, Luigi; Fevre, Anne; Nettore, Immacolata Cristina; Manilall, Ashmeetha; Francou, Bruno; Trabado, Severine; Bouligand, Jerome; Guiochon-Mantel, Anne; Delemer, Brigitte; Flanagan, Colleen A.; Macchia, Paolo Emidio; Millar, Robert P.; Young, Jacques (Oxford University Press, 2019-01)

STUDY QUESTION : Does the phenotype of women with normosmic congenital hypogonadotrophic hypogonadism (nCHH) and pituitary resistance to GnRH caused by biallelic mutations in the GnRH receptor (GNRHR) (nCHH/bi-GNRHR) differ ...
Small molecule follicle-stimulating hormone receptor agonists and antagonists

Anderson, Ross Calley; Newton, Claire L.; Millar, Robert P. (Frontiers Media, 2019-01-23)

The follicle-stimulating hormone receptor (FSHR) has been targeted therapeutically for decades, due to its pivotal role in reproduction. To date, only purified and recombinant/biosimilar FSH have been used to target FSHR ...

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Browsing Research Articles (Physiology) by Author "Millar, Robert P."

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