Browsing Research Articles (Physiology) by Title

Browsing Research Articles (Physiology) by Title

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  • Belangrikheid van antropometrie, fisiese en motoriese vaardighede, sport spesifieke toetsing en sport visie tegnieke in die evaluering van rugbyspelers 
    Gray, S.; Henning, E.; Kleynhans, Michael; Grobbelaar, C.W. (Craig); Terblanche, H.C.; Crafford, Dalene; Du Toit, Peet J. (Suid Afrikaanse Akademie vir Wetenskap & Kuns, 2012)
    Sport has become an increasingly competitive field of expertise, thus it is imperative that an athlete is able to perform at the highest level possible at all times. Many coaches and athletes are under the false impression ...
  • Bepaling van harttempovariasie ’n vergelyking tussen direkte bepaling vanaf V6 van die EKG en tyddomein frekwensiedomein en nielineêre analise 
    Grant, C.C. (Catharina Cornelia); Becker, Piet J.; Viljoen, Margaretha (Suid-Afrikaanse Akademie vir Wetenskap en Kuns, 2006-06)
    Tydens die normale funksionering van die hart fluktueer die intervalle tussen opeenvolgende hartslae (R-R-intervalle) rondom 'n gemiddelde waarde. Hierdie fluktuering staan bekend as harttempovariasie (HTV). Verskillende ...
  • Bigeminy and the bifid papillary muscle 
    Ker, James A. (BioMed Central, 2010)
    Various structural anomalies of the left ventricular papillary muscles have been observed in recent years. Many of these have been linked to electrocardiographic aberrations. Recently two reports have appeared where the ...
  • Binding pose analysis of hydroxyethylamine based β-secretase inhibitors and application thereof to the design and synthesis of novel indeno[1,2-b]indole based inhibitors 
    Van der Westhuizen, Carl Johan; Van Greunen, D.G. (Divan); Cordier, Werner; Nell, Margo Judith; Steenkamp, Vanessa; Stander, Andre; Panayides, Jenny-Lee; Riley, Darren L. (ARKAT, 2020-04)
    β-Secretase (BACE1) is recognised as a target for the treatment of Alzheimer’s disease, and transition-state isosteres such as hydroxyethylamines have shown promise when incorporated into BACE1 inhibitors. A computational ...
  • The biological relevance of Papaverine in cancer cells 
    Gomes, D.A.; Joubert, Anna Margaret; Visagie, M.H. (Michelle Helen) (MDPI, 2022-10-26)
    Papaverine (PPV), a benzylisoquinoline alkaloid, extracted from the Papaverine somniferum plant, is currently in clinical use as a vasodilator. Research has shown that PPV inhibits phosphodiesterase 10A (PDE10A,) resulting ...
  • Biomechanics without borders : teaching biomechanics in Brazil and South Africa 
    Bayne, Helen; Albertus, Yumna; Breen, Sarah; Green, Andrew; De Andrade, Andre Gustavo; Kramer, Mark; Carpes, Felipe P. (American Physiological Society, 2021)
    The “Biomechanics without Borders: Teaching Biomechanics in Brazil and South Africa” involved academics from different countries combining efforts to improve remote education. In addition to the live discussions, the event ...
  • Biomechanics without borders : teaching biomechanics in Brazil and South Africa 
    Bayne, Helen; Albertus, Yumna; Breen, Sarah; Green, Andrew; De Andrade, Andre Gustavo; Kramer, Mark; Carpes, Felipe P. (American Physiological Society, 2021-03)
    The “Biomechanics without Borders: Teaching Biomechanics in Brazil and South Africa” involved academics from different countries combining efforts to improve remote education. In addition to the live discussions, the event ...
  • A bis-sulphamoylated estradiol derivative induces ROS-dependent cell cycle abnormalities and subsequent apoptosis 
    Visagie, M.H. (Michelle Helen); Van den Bout, Jan Iman; Joubert, Annie M. (Public Library of Science, 2017-04-14)
    Clinical trials have revealed that the potential anticancer agent, 2-methoxyestradiol (2ME2) has limitations due to its low bioavailability. Subsequently, 2ME2 derivatives including (8R, 13S,14S,17S)-2-ethyl-13-methyl- ...
  • Bone density and depression in premenopausal South African women : a pilot study 
    Govender, Catherine; Du Plessis, Anna M.E.; Bipath, Priyesh; Povey, D.; Viviers, G.; Viljoen, Margaretha (In House Publications, 2010-03)
    OBJECTIVE: It is posited that the effect of depression on BMD is dependent on the severity of depression. Conflicting evidence exists regarding this possible association. This study investigated the association between ...
  • The Brody effect induced by premature ventricular complexes in the ovine heart 
    Ker, James A.; Webb, E.C. (Edward Cottington); Van Papendorp, D.H. (Dirk Hermanus), 1949- (Agricultural Research Council, ARC-OVI and the University of Pretoria, 2009-12)
    The QRS response of the electrocardiogram to bleeding has been a source of interest to the physiologist for more than a century. Studies in the dog, cat and chicken have shown a reduction in QRS amplitude in response to ...
  • C2- and C4-position 17β-estradiol metabolites and their relation to breast cancer 
    Joubert, Annie M.; Van Zyl, Hermia; Laurens, Johannes B.; Lottering, Mona-Liza (Centro Regional de Investigaciones Cientificas Y Tecnologicas / Universidad Nacional de Cuyo, 2009)
    C2- and C4-position 17β-estradiol metabolites play an important role in breast carcinogenesis. 2-Hydroxyestradiol and 4-hydroxyestradiol are implicated in tumorigenesis via two pathways. These pathways entail increased ...
  • Cancer genomics 
    Joubert, Annie M. (Academy of Science South Africa, 2020)
    No abstract available.
  • Cancer stem cells in head and neck carcinomas : identification and possible therapeutic implications 
    Wolmarans, Elize; Boy, S.C. (Sonja); Nel, Sulette; Mercier, Anne Elisabeth; Pepper, Michael Sean (Springer, 2017-11)
    The recurrence and/or lack of response of certain tumors to radio- and chemotherapy has been attributed to a small subpopulation of cells termed cancer stem cells (CSCs). CSCs have been identified in many tumors (including ...
  • Carbon monoxide : anticoagulant or procoagulant? 
    Nielsen, Vance G.; Pretorius, Etheresia (Elsevier, 2014-03)
    Within the past decade there have been several investigations attempting to define the impact of exogenous and endogenous carbon monoxide exposure on hemostasis. Critically, two bodies of literature have emerged, with carbon ...
  • Carbon monoxide and iron modulate plasmatic coagulation in Alzheimer's disease 
    Nielsen, Vance G.; Pretorius, Etheresia; Bester, Janette; Jacobsen, Wayne K.; Boyle, Patrick K.; Reinhard, Joao P. (Bentham Science, 2015-01)
    Alzheimer’s disease (AD) is a significant source of morbidity and mortality for millions of people worldwide, and multiple potential etiologies have been postulated to contribute to AD. Among these, spontaneous cerebral ...
  • Cardiovascular health screening among South African students 
    Du Toit, Peet J.; Kruger, Ernst H.; Govender, Catherine; Henning, E.; Kleynhans, Michael; Wood, Paola Silvia; De Villiers, Nico P.; Van Rooyen, J.M.; Fletcher, Lizelle; Grant, C.C. (Catharina Cornelia) (Africa Association for Health, Physical Education, Recreation, Sport and Dance, 2012-03)
    Stress is an unavoidable part of everyday life due to the demands and stressors associated with modern lifestyle. Health risks provoked by this increasingly prevalent condition lead to cardiovascular disease, which ultimately ...
  • Carvacrol inhibits osteoclastogenesis and negatively regulates the survival of mature osteoclasts 
    Deepak, Vishwa; Kasonga, Abe E.; Kruger, Marlena C.; Coetzee, Magdalena (Pharmaceutical Society of Japan, 2016-07)
    Bone is a dynamic tissue that undergoes continuous remodeling coupled with the action of osteoblasts and osteoclasts. Osteoclast activity is elevated during osteoporosis and periodontitis resulting in excessive loss of ...
  • A case of takotsubo cardiomyopathy precipitated by lumiracoxib, a selective COX-2 inhibitor 
    Ker, James A.; Van Wyk, C.J. (Clinics Cardiv, 2007-11)
    Considerable controversy exists regarding the cardiovascular safety of COX-2 inhibitors, both in patients with and without established cardiovascular disease. Currently, the major focus is on thrombotic complications ...
  • A case of unexplained cyanosis 
    Soma, Prashilla; Ellemdin, Shiraz (Clinics Cardiv, 2012-09)
    It is now clear that hepatopulmonary syndrome (HPS) may occur and contribute significantly to gas exchange abnormalities in the setting of other cardiopulmonary abnormalities. Since there is no gold-standard diagnostic ...
  • Cell fate following irradiation of MDA-MB-231 and MCF-7 breast cancer cells pre-exposed to the setrahydroisoquinoline sulfamate microtubule disruptor STX3451 
    Hargrave, Scott Daniel; Joubert, Anna Margaretha; Potter, Barry V.L.; Dohle, Wolfgang; Marais, Sumari; Mercier, Anne Elisabeth (MDPI, 2022-06-14)
    Atetrahydroisoquinoline (THIQ) core is able tomimic theAand B rings of 2-methoxyestradiol (2ME2), an endogenous estrogen metabolite that demonstrates promising anticancer properties primarily by disrupting microtubule ...