Browsing Research Articles (Medical Microbiology) by Author "Gandhi, Neel R."

Browsing Research Articles (Medical Microbiology) by Author "Gandhi, Neel R."

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  • Extensively drug-resistant tuberculosis hotspots and sociodemographic associations in Durban, South Africa 
    Peterson, Meaghan L.; Gandhi, Neel R.; Clennon, Julie; Nelson, Kristin N.; Morris, Natashia; Ismail, Nazir Ahmed; Allana, Salim; Campbell, Angie; Brust, James C.M.; Auld, Sara C.; Mathema, Barun; Mlisana, Koleka; Moodley, Pravi; Shah, N. Sarita (International Union Against Tuberculosis and Lung Disease, 2019-06)
    BACKGROUND : Extensively drug-resistant tuberculosis (XDR-TB) incidence is driven by transmission of resistant strains in KwaZulu-Natal, South Africa. Data suggests cases may be spatially clustered; we therefore sought to ...
  • Incidence and geographic distribution of extensively drug-resistant tuberculosis in KwaZulu-Natal Province, South Africa 
    Lim, Jennifer R.; Gandhi, Neel R.; Mthiyane, Thuli; Mlisana, Koleka; Moodley, Julie; Jaglal, Prenika; Ramdin, Neeshan; Brust, James C.M.; Ismail, Nazir Ahmed; Rustomjee, Roxana; Shah, N. Sarita (Public Library of Science, 2015-07-06)
    South Africa is experiencing a widespread drug-resistant tuberculosis epidemic, although data are limited regarding the current situation. This study finds that the extensively drugresistant tuberculosis (XDR-TB) incidence ...
  • Modeling missing cases and transmission links in networks of extensively drug-resistant tuberculosis in KwaZulu-Natal, South Africa 
    Nelson, Kristin N.; Gandhi, Neel R.; Mathema, Barun; Lopman, Benjamin A.; Brust, James C.M.; Auld, Sara C.; Ismail, Nazir Ahmed; Omar, Shaheed Vally; Brown, Tyler S.; Allana, Salim; Campbell, Angie; Moodley, Pravi; Mlisana, Koleka; Shah, N. Sarita; Jenness, Samuel M. (Oxford University Press, 2020-07)
    Patterns of transmission of drug-resistant tuberculosis (TB) remain poorly understood, despite over half a million incident cases worldwide in 2017. Modeling TB transmission networks can provide insight into drivers of ...
  • Pre-detection history of extensively drug-resistant tuberculosis in KwaZulu-Natal, South Africa 
    Brown, Tyler S.; Challagundla, Lavanya; Baugh, Evan H.; Omar, Shaheed Vally; Mustaev, Arkady; Auld, Sara C.; Shah, N. Sarita; Kreiswirth, Barry N.; Brust, James C.M.; Nelson, Kristin N.; Narechania, Apurva; Kurepina, Natalia; Mlisana, Koleka; Bonneau, Richard; Eldholm, Vegard; Ismail, Nazir Ahmed; Kolokotronis, Sergios-Orestis; Robinson, D. Ashley; Gandhi, Neel R.; Mathema, Barun (National Academy of Sciences, 2019-11)
    Antimicrobial-resistant (AMR) infections pose a major threat to global public health. Similar to other AMR pathogens, both historical and ongoing drug-resistant tuberculosis (TB) epidemics are characterized by transmission ...
  • Social mixing and clinical features linked with transmission in a network of extensively drug-resistant tuberculosis cases in KwaZulu-Natal, South Africa 
    Nelson, Kristin N.; Jenness, Samuel M.; Mathema, Barun; Lopman, Benjamin A.; Auld, Sara C.; Shah, N. Sarita; Brust, James C.M.; Ismail, Nazir Ahmed; Omar, Shaheed Vally; Brown, Tyler S.; Allana, Salim; Campbell, Angie; Moodley, Pravi; Mlisana, Koleka; Gandhi, Neel R. (Oxford University Press, 2020-06)
    BACKGROUND: Tuberculosis (TB) is the leading infectious cause of death globally, and drug-resistant TB strains pose a serious threat to controlling the global TB epidemic. The clinical features, locations, and social factors ...
  • Spatial patterns of extensively drug-resistant tuberculosis transmission in KwaZulu-Natal, South Africa 
    Nelson, Kristin N.; Shah, N. Sarita; Mathema, Barun; Ismail, Nazir Ahmed; Brust, James C.M.; Brown, Tyler S.; Auld, Sara C.; Omar, Shaheed Vally; Morris, Natashia; Campbell, Angie; Allana, Salim; Moodley, Pravi; Mlisana, Koleka; Gandhi, Neel R. (Oxford University Press, 2018-12-15)
    BACKGROUND : Transmission is driving the global drug-resistant tuberculosis (TB) epidemic; nearly three-quarters of drug-resistant TB cases are attributable to transmission. Geographic patterns of disease incidence, combined ...
  • Tryptophan catabolism reflects disease activity in human tuberculosis 
    Collins, Jeffrey M.; Siddiqa, Amnah; Jones, Dean P.; Liu, Ken; Kempker, Russell R.; Nizam, Azhar; Shah, N. Sarita; Ismail, Nazir Ahmed; Ouma, Samuel G.; Tukvadze, Nestani; Li, Shuzhao; Day, Cheryl L.; Rengarajan, Jyothi; Brust, James C.M.; Gandhi, Neel R.; Ernst, Joel D.; Blumberg, Henry M.; Ziegler, Thomas R. (American Society for Clinical Investigation, 2020-05-05)
    There is limited understanding of the role of host metabolism in the pathophysiology of human tuberculosis (TB). Using high-resolution metabolomics with an unbiased approach to metabolic pathway analysis, we discovered ...