South Africa is experiencing a widespread drug-resistant tuberculosis epidemic, although
data are limited regarding the current situation. This study finds that the extensively drugresistant
tuberculosis (XDR-TB) incidence in KwaZulu-Natal increased to 3.5 cases/
100,000 (776 cases) in 2011-2012. XDR-TB cases are widely distributed geographically,
with the majority of districts experiencing a rise in incidence.