Browsing Research Articles (Medical Microbiology) by Title

Browsing Research Articles (Medical Microbiology) by Title

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  • Orthobunyavirus antibodies among humans in selected parts of the Rift Valley and northeastern Kenya 
    Odhiambo, Collins; Venter, Marietjie; Swanepoel, Robert; Sang, Rosemary (Mary Ann Liebert, 2015-05)
    Ngari, Bunyamwera, Ilesha, and Germiston viruses are among the mosquito-borne human pathogens in the Orthobunyavirus genus, family Bunyaviridae, associated with febrile illness. Although the four orthobunyaviruses have ...
  • Outbreak of carbapenem-resistant Providencia rettgeri in a tertiary hospital 
    Tshisevhe, V.S.; Lekalakala, M.R.; Tshuma, N.; Janse van Rensburg, S.; Mbelle, Nontombi Marylucy (Health and Medical Publishing Group, 2017)
    The emergence of resistance to multiple antimicrobial agents in pathogenic bacteria is a significant public health threat, as there are limited effective antimicrobial agents for infections caused by multidrug-resistant ...
  • Outbreak of Ralstonia mannitolilytica bacteraemia in patients undergoing haemodialysis at a tertiary hospital in Pretoria, South Africa 
    Said, Mohamed; Van Hougenhouck-Tulleken, W.G. (Wesley); Naidoo, Rashmika; Mbelle, Nontombi Marylucy; Ismail, Farzana (BMC, 2020-07)
    BACKGROUND: Ralstonia species are Gram-negative bacilli of low virulence. These organisms are capable of causing healthcare associated infections through contaminated solutions. In this study, we aimed to determine the ...
  • Part IV. Human infections and antibiotic resistance 
    Crowther-Gibson, Penny; Govender, N.; Lewis, D.A.; Bamford, C.; Brink, A.; Von Gottberg, Anne; Klugman, Keith P.; Du Plessis, M.; Fali, A.; Harris, B.; Keddy, Karen H.; Botha, M. (Health and Medical Publishing Group, 2011-08)
    South Africa has a high burden of infectious diseases, including a large portion that are of bacterial origin. This section reviews the national burden of disease and levels of antibiotic resistance in common bacterial ...
  • Part V. Surveillance activities 
    Bamford, C.; Brink, A.; Govender, N.; Lewis, D.A.; Perovic, Olga; Botha, M.; Harris, B.; Keddy, Karen H.; Gelband, H.; Duse, A.G. (Health and Medical Publishing Group, 2011-08)
    The critical importance of robust antimicrobial resistance (AMR) surveillance in South Africa cannot be overemphasised. Without knowing what the resistance situation is, it is impossible to develop appropriate antibiotic ...
  • Part VII : Interventions 
    Visser, Adele; Moore, D.P.; Whitelaw, Andrew; Lowman, W.; Kantor, G.; Hoosen, Anwar Ahmed; Madhi, Shabir A.; Brink, A.; Van den Bergh, D.; Devenish, L.; Moodley, P.; Apalata, T.; Duse, A.G.; Gelband, H. (Health and Medical Publishing Group, 2011-08)
    Antimicrobial resistance (AMR) surveillance activities in South Africa have been described in Part V of this report. Surveillance – knowing the levels of resistance and the trends around the country and in different ...
  • Pathogenomics and evolutionary epidemiology of multi-drug resistant clinical Klebsiella pneumoniae isolated from Pretoria, South Africa 
    Mbelle, Nontombi Marylucy; Feldman, Charles; Osei Sekyere, John; Maningi, Nontuthuko Excellent; Modipane, Lesedi; Essack, Sabiha Yusuf (Nature Publishing Group, 2020)
    Antibiotic-resistant Klebsiella pneumoniae is increasingly being implicated in invasive infections worldwide with high mortalities. Forty-two multidrug resistant (MDR) K. pneumoniae isolates were collected over a 4-month ...
  • Patient with protracted abdominal pain 
    Nyapholi, Mohapi; Geldenhuys, Annelize; Visser, Adele (Federation of Infectious Diseases Societies of South Africa, 2013)
    Actinomycosis is very often misdiagnosed as typically, the associated laboratory and radiological findings are nonspecific. Therefore, clinicians should always have a high index of suspicion in cases in which there is ...
  • Pediatric disease burden and vaccination recommendations : understanding local differences 
    Gentile, Angela; Bhutta, Zulfiqar; Bravo, Lulu; Samy, Aly Gamal; Garcia, R. Dennis J.; Hoosen, Anwar Ahmed; Islam, Tazul; Karimi, Abdollah; Salem, Mona; Simasathien, Sriluck; Sohail, Amir; Watanaveeradej, Veerachai; Wiedenmayer, Karin; Schmitt, Heinz-J. (Elsevier, 2010)
    BACKGROUND: Diphtheria (D), tetanus (T), pertussis (P), hepatitis B (HepB), invasive Haemophilus influenzae type b (Hib) disease, and measles cause substantial global morbidity and mortality. METHODS: This unique review ...
  • Performance evaluation of three commercial molecular assays for the detection of Mycobacterium tuberculosis from clinical specimens in a high TB-HIV-burden setting 
    Matabane, M.M.Z.; Ismail, Farzanah; Strydom, Kathy-Anne; Onwuegbuna, O.; Omar, Shaheed Vally; Ismail, Nabila (BioMed Central, 2015-11-09)
    BACKGROUND : A major challenge faced by countries with a high burden of tuberculosis (TB) is early detection especially in individuals with paucibacillary disease which is common in HIV endemic settings. Remarkable efforts ...
  • Performance of a novel algorithm using automated digital microscopy for diagnosing tuberculosis 
    Ismail, Nazir Ahmed; Omar, Shaheed Vally; Lewis, James J.; Dowdy, David W.; Dreyer, Andries W.; Van der Meulen, Hermina; Nconjana, George; Clark, David A.; Churchyard, Gavin J. (American Thoracic Society, 2015-06)
    RATIONALE : TBDx automated microscopy is a novel technology that processes digital microscopic images to identify acid-fast bacilli (AFB). Use of TBDx as part of a diagnostic algorithm could improve the diagnosis of ...
  • Persistent Chlamydia trachomatis, Neisseria gonorrhoeae or Trichomonas vaginalis positivity after treatment among human immunodeficiency virus-infected pregnant women, South Africa 
    Medina-Marino, Andrew; Mudau, Maanda; Kojima, Noah; Peters, Remco P.H.; Feucht, Ute Dagmar; De Vos, Lindsey; Olivier, Dawie; Muzny, Christina A.; McIntyre, James A.; Klausner, Jeffrey D. (Sage, 2020-03)
    The objective of this study is to assess the predictors and frequency of persistent sexually transmitted infection (STI) positivity in human immunodeficiency virus (HIV)-infected pregnant women treated for Chlamydia ...
  • Persister populations of Mycobacterium tuberculosis in sputum that grow in liquid but not on solid culture media 
    Dhillon, Jasvir; Fourie, P.B. (Petrus Bernardus); Mitchison, D.A. (Oxford University Press, 2014-02)
    OBJECTIVES : Can the characteristics of persisters in cultures of Mycobacterium tuberculosis also be found in bacilli from the sputum of pulmonary tuberculosis patients? The objective of this study was to explore whether ...
  • A phase 2 study to evaluate the safety and immunogenicity of a recombinant HIV type 1 vaccine based on adeno-associated virus 
    Vardas, Eftyxia; Kaleebu, Pontiano; Bekker, Linda-Gail; Hoosen, Anwar Ahmed; Chomba, Elwyn; Johnson, Philip R.; Anklesaria, Pervin; Birungi, Josephine; Barin, Burc; Boaz, Mark; Cox, Josephine; Lehrman, Jennifer; Stevens, Gwynn; Gilmour, Jill; Tarragona, Tony; Hayes, Peter; Lowenbein, Sarah; Kizito, Eva; Fast, Patricia; Heald, Alison E.; Schmidt, Claudia (Mary Ann Liebert, 2010)
    The recombinant vaccine, tgAAC09, based on an adeno-associated virus serotype 2 (AAV2) vector encoding HIV-1 subtype C Gag, protease, and part of reverse transcriptase, induced robust T cell and antibody responses in ...
  • Phase I, single-dose, dose-escalating study of inhaled dry powder capreomycin : a new approach to therapy of drug-resistant tuberculosis 
    Dharmadhikari, Ashwin S.; Kabadi, Mohan; Gerety, Bob; Hickey, Anthony J.; Fourie, P.B. (Petrus Bernardus); Nardell, Edward Anthony (American Society for Microbiology, 2013-06)
    Multidrug-resistant tuberculosis (MDR-TB) threatens global TB control. The lengthy treatment includes one of the injectable drugs kanamycin, amikacin, and capreomycin, usually for the first 6 months. These drugs have ...
  • Phylogenomic and epidemiological insights into two clinical Mycobacterium bovis BCG strains circulating in South Africa 
    Modipane, Lesedi; Reva, Oleg N.; Magazi, Beki T.; Antiabong, John Francis; Osei Sekyere, John; Mbelle, Nontombi Marylucy (Elsevier, 2019-10)
    BACKGROUND : Mycobacterium bovis BCG is a live, attenuated tuberculosis vaccine. While the vaccine protects infants from tuberculosis, complications including disseminated infections have been reported following ...
  • Plasmid evolution in carbapenemase‐producing Enterobacteriaceae : a review 
    Kopotsa, Katlego; Osei Sekyere, John; Mbelle, Nontombi Marylucy (Wiley, 2019-12)
    Please read abstract in the article.
  • Plasmodium ovale : a case of not-so-benign tertian malaria 
    Strydom, Kathy-Anne; Ismail, Farzanah; Frean, John (BioMed Central, 2014-03-10)
    Severe malaria is most commonly associated with Plasmodium falciparum. Plasmodium vivax is increasingly recognized as being capable of causing severe disease. In contrast, Plasmodium ovale is considered as a cause of benign ...
  • Population dynamics of Escherichia coli causing bloodstream infections over extended time periods 
    Pitout, Johann D.D. (American Society for Microbiology, 2021-12-22)
    Escherichia coli is a leading cause of community-acquired and health careassociated bloodstream infections (BSIs) worldwide. Limited information is available regarding the changes in population dynamics of human E. coli ...
  • Population pharmacokinetic drug-drug interaction pooled analysis of existing data for rifabutin and HIV PIs 
    Hennig, Stefanie; Svensson, Elin M.; Niebecker, Ronald; Fourie, P.B. (Petrus Bernardus); Weiner, Marc H.; Bonora, Stefano; Peloquin, Charles A.; Gallicano, Keith; Flexner, Charles; Pym, Alex; Vis, Peter; Olliaro, Piero L.; McIlleron, Helen; Karlsson, Mats O. (Oxford University Press, 2016-05)
    OBJECTIVES : Extensive but fragmented data from existing studies were used to describe the drug-drug interaction between rifabutin and HIV-protease inhibitors, and predict doses achieving recommended therapeutic exposure ...