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Browsing Research Articles (Biochemistry) by UP Author "Meyer, Debra"
Now showing items 1-20 of 23
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Kapewangolo, Petrina T.; Kandawa-Schulz, Martha; Meyer, Debra (MDPI Publishing, 2017-11-06)Ocimum plants are traditionally used to manage HIV/AIDS in various African countries. The effects of Ocimum labiatum extract on HIV-1 protease (PR) and reverse transcriptase (RT) is presented here along with characterization ...
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Kapewangolo, Petrina T.; Omolo, Justin J.; Bruwer, Ronel; Fonteh, Pascaline Nanga; Meyer, Debra (BioMed Central, 2015-12)BACKGROUND : Plants from the genus Ocimum are used as folk medicine for treating various diseases including inflammatory and immune-related diseases. Numerous reports have suggested plant extracts and their constituents as ...
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Le Roux, Karlien; Prinsloo, Linda Charlotta; Meyer, Debra (Elsevier, 2015-03)Fourier Transform Infrared (FTIR) spectroscopy is finding increasing biological application, for example in the analysis of diseased tissues and cells, cell cycle studies and investigating the mechanisms of action ...
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McKnight, Tracy R.; Yoshihara, Hikari A.I.; Sitole, Lungile J.; Martin, Jeffery N.; Steffens, Francois E.; Meyer, Debra (Royal Society of Chemistry, 2014-08-08)Individuals infected with the human immunodeficiency virus (HIV) often suffer from concomitant metabolic complications. Treatment with antiretroviral therapy has also been shown to alter the metabolism of patients. Although ...
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Tukulula, Matshawandile; Hayeshi, Rose; Fonteh, Pascaline Nanga; Meyer, Debra; Ndamase, Abongile; Madziva, Michael Taurai; Khumalo, Vincent; Lubuschagne, Philip; Naicker, Brendon; Swai, H.; Dube, Admire (Springer, 2015-08)PURPOSE : There is significant interest in the application of nanoparticles to deliver immunostimulatory signals to cells. We hypothesized that curdlan (immune stimulating polymer) could be conjugated to PLGA and ...
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Ellithey, M.S. (Mona); Lall, Namrita; Hussein, Ahmed A.; Meyer, Debra (BioMed Central, 2014-02-25)BACKGROUND: Cancer and HIV/AIDS are two of the greatest public health and humanitarian challenges facing the world today. Infection with HIV not only weakens the immune system leading to AIDS and increasing the risk ...
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Ellithey, M.S. (Mona); Lall, Namrita; Hussein, Ahmed A.; Meyer, Debra (MDPI, 2013-12)Bioassay-guided fractionation using different chromatographic and spectroscopic techniques in the analysis of the Red Sea soft coral Litophyton arboreum led to the isolation of nine compounds; sarcophytol M (1), alismol ...
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Le Roux, Karlien; Prinsloo, Linda Charlotta; Meyer, Debra (Elsevier, 2015-10)Fourier Transform Infrared (FTIR) spectroscopy is a label free methodology showing promise in characterizing different types of cell death. Cervical adenocarcinoma (HeLa) and African monkey kidney (Vero) cells were treated ...
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Masebe, Tracy; Bessong, Pascal Obong; Ndip Ndip, Roland; Meyer, Debra (MDPI Publishing, 2014-06-26)Metabolic disorders and hypersensitivities affect tolerability and impact adherence to highly active antiretroviral therapy (HAART). The aim of this study was to determine the prevalence of C-482T/T-455C variants in the ...
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Gama, Ntombenhle Hlengiwe; Kumar, Kamlesh; Ekengard, Erik; Haukka, Matti; Darkwa, James; Nordlander, Ebbe; Meyer, Debra (Springer, 2016-06)HIV infection is known for replication in proliferating CD+ T-cells. Treatment of these cells with cytostatic (anti-proliferation) compounds such as hydroxyurea interferes with the cells’s ability support HIV replication. ...
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Fonteh, Pascaline Nanga; Keter, Frankline K.; Meyer, Debra (Springer, 2010-02)Highly active antiretroviral therapy (HAART) has resulted in decreased mortality and morbidity from the acquired immune deficiency syndrome caused by the human immunodeficiency virus (HIV). Drug resistance and toxicity ...
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Fonteh, Pascaline Nanga; Elkhadir, A.; Omondi, B.; Guzei, I.; Darkwa, J.; Meyer, Debra (Springer, 2015-08)Label free impedance technology enables the monitoring of cell response patterns post treatment with drugs or other chemicals. Using this technology, a correlation between the lipophilicity of metal complexes and the ...
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Fonteh, Pascaline Nanga; Meyer, Debra (BioMed Central, 2014-12)BACKGROUND : A number of cytostatic agents have been investigated for the ability to reactivate latent viral reservoirs, which is a major prerequisite for the eradication of HIV-1 infection. Two cytostatic bis(thiosemi ...
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Inhibition of HIV-1 enzymes, antioxidant and anti-inflammatory activities of Plectranthus barbatus Kapewangolo, Petrina T.; Hussein, Ahmed A.; Meyer, Debra (Elsevier, 2013-08)ETHNOPHARMACOLOGICAL RELEVANCE : Plectranthus barbatus is widely used in African countries as an herbal remedy to manage HIV/AIDS and related conditions. AIM OF STUDY : To investigate the HIV-1 inhibitory, anti-inflammatory ...
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Sitole, Lungile J.; Williams, Aurelia Alvina; Meyer, Debra (Royal Society of Chemistry, 2013)Monitoring the progression of HIV infection to full-blown acquired immune deficiency syndrome (AIDS) and assessing responses to treatment will benefit greatly from the identification of novel biological markers especially ...
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Le Roux, Karlien; Prinsloo, Linda Charlotta; Meyer, Debra (American Institute of Physics, 2014)Chrysotherapeutics are under investigation as new or additional treatments for different types of cancers. In this study, gold complexes were investigated for their anticancer potential using Raman spectroscopy. The aim ...
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Mid-ATR-FTIR spectroscopic profiling of HIV/AIDS sera for novel systems diagnostics in global health Sitole, Lungile J.; Steffens, Francois E.; Kruger, T.P.J. (Tjaart); Meyer, Debra (Mary Ann Liebert, 2014)Please read abstract in the article.
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Fonteh, Pascaline Nanga; Keter, Frankline K.; Meyer, Debra (Elsevier, 2011-09)Four bis(thiosemicarbazonate)gold(III) complexes (1–4) with a general formula [Au(L)]Cl {L=L1, glyoxal-bis (N4-methylthiosemicarbazone); L2, glyoxal-bis(N4-ethylthiosemicarbazone); L3, diacetyl-bis(N4- methylthiosemicarbazone); ...
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Fonteh, Pascaline Nanga; Meyer, Debra (Royal Society of Chemistry, 2009-08)The increasing incidence of human immunodeficiency virus (HIV) infection and the associated acquired immune deficiency syndrome (AIDS) mortality rates as well as the sometimes severe side effects of highly active anti ...
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Prevalence of MDR1 C3435T and CYP2B6 G516T polymorphisms among HIV-1 infected South African patients Masebe, Tracy Madimabi; Bessong, Pascal Obong; Nwobegahay, Julius; Ndip, Roland Ndip; Meyer, Debra (IOS Press, 2012)Data on genetic polymorphisms associated with response to anti-HIVdrugs has accumulated over the years. Information on how polymorphisms influence drug metabolism and transport to target sites is important in guiding ...
Now showing items 1-20 of 23