dc.contributor.author |
Van Dyk, Enette
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dc.contributor.author |
Bosman, Anna-Mari
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dc.contributor.author |
Van Wilpe, Erna
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dc.contributor.author |
Williams, June Heather
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dc.contributor.author |
Bengis, Roy G.
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dc.contributor.author |
Van Heerden, J.
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dc.contributor.author |
Venter, Estelle Hildegard
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dc.date.accessioned |
2011-08-24T07:29:53Z |
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dc.date.available |
2011-08-24T07:29:53Z |
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dc.date.issued |
2011-04 |
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dc.description.abstract |
Papillomavirus was detected electron microscopically in cutaneous fibropapillomas of a giraffe (Giraffa camelopardalis) and a sable antelope (Hippotragus niger). The virus particles
measured 45 nm in diameter. Histopathologically, the lesions showed histopathological features similar to those of equine sarcoid as well as positive immunoperoxidase-staining of
tissue sections for papillomavirus antigen. Polymerase chain reaction (PCR) detected bovine papillomavirus (BPV) DNA. Bovine papillomavirus-1 was characterised by real-time PCR in the sable and giraffe, and cloning and sequencing of the PCR product revealed a similarity to BPV-1. As in the 1st giraffe, the lesions from a 2nd giraffe revealed locally malignant pleomorphism, possibly indicating the lesional end-point of papilloma infection. Neither virus particles nor positively staining papillomavirus antigen could be demonstrated in the 2nd giraffe but papillomavirus DNA was detected by real-time PCR which corresponded with BPV-1 and BPV-2. |
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dc.description.sponsorship |
Grants from the South African Veterinary Foundation,
the Research and Development Fund of the University of Pretoria, and the Department of Veterinary Tropical Diseases, Faculty of Veterinary Science, University of Pretoria. |
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dc.description.uri |
http://www.journals.co.za/ej/ejour_savet.html |
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dc.identifier.citation |
Van Dyk, E, Bosman, A-M, Van Wilpe, E, Williams, JH, Bengis, RG, Van Heerden, J & Venter, EH 2011, ‘Detection and characterisation of papillomavirus in skin lesions of giraffe and sable antelope in South Africa’, Journal of the South African Veterinary Association, vol. 82, no. 2, pp. 80–85. |
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dc.identifier.issn |
0038-2809 |
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dc.identifier.other |
7003904650 |
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dc.identifier.other |
O-6953-2014 |
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dc.identifier.uri |
http://hdl.handle.net/2263/17147 |
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dc.language.iso |
en |
en |
dc.publisher |
South African Veterinary Association |
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dc.relation.requires |
Adobe Acrobat Reader |
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dc.rights |
South African Veterinary Association |
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dc.subject |
Cutaneous fibropapillomas |
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dc.subject |
Giraffe (Giraffa camelopardalis) |
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dc.subject |
Hippotragus niger |
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dc.subject |
Malignant pleomorphism |
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dc.subject |
Skin lesions |
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dc.subject.lcsh |
Papillomaviruses |
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dc.subject.lcsh |
Giraffe |
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dc.subject.lcsh |
Sable antelope |
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dc.title |
Detection and characterisation of papillomavirus in skin lesions of giraffe and sable antelope in South Africa |
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dc.type |
Article |
en |