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Browsing Health Sciences by UP Author "Theron, Annette J."
Now showing items 1-20 of 40
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Opolot, J.O.; Theron, Annette J.; Anderson, Ronald; Feldman, Charles (Springer, 2015-02)INTRODUCTION : Despite the high burden of disease, there have been surprisingly few studies of the acute phase and plasma catecholamine/cortisol stress hormone responses in patients with active pulmonary tuberculosis. ...
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Anderson, Ronald; Theron, Annette J.; Steel, Helen C.; Nel, Jan Gert; Tintinger, Gregory Ronald (MDPI Publishing, 2020-12)This study probed the di erential utilization of P2Y1 and P2Y12 receptors in mobilizing CD62P (P-selectin) from intracellular granules following activation of human platelets with adenosine 50-diphosphate (ADP, 100 mol L1) ...
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Anderson, Ronald; Theron, Annette J.; Steel, Helen C.; Durandt, Chrisna; Tintinger, Gregory Ronald; Feldman, Charles (Hindawi Publishing Corporation, 2014-03)The clinical relevance of the anti-inflammatory properties of beta-2 agonists remains contentious possibly due to differences in their molecular structures and agonist activities. The current study has compared the effects ...
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Cockeran, Riana; Mutepe, Ndiafhi Daphney; Theron, Annette J.; Tintinger, Gregory Ronald; Steel, Helen C.; Stivaktas, Paraskevi Irene; Richards, Guy A.; Feldman, Charles; Anderson, Ronald (Oxford University Press, 2012)OBJECTIVES: Tigecycline is the prototype of the recently introduced, intravenously administered glycylcycline class of antibiotics, developed in response to the increasing problem of antibiotic resistance in Gram-positi ...
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Cockeran, Riana; Steel, Helen C.; Theron, Annette J.; Mitchell, Timothy J.; Feldman, Charles; Anderson, Ronald (Elsevier, 2011-11)The pneumolysin toxoid, Δ6 PLY, is a prototype pneumococcal protein vaccine candidate. However, its potentially detrimental residual pro-inflammatory interactions with human neutrophils are unknown. In the current study ...
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Cigarette smoke condensate attenuates phorbol ester-mediated neutrophil extracellular trap formation Bokaba, Refilwe Philadelphia; Anderson, Ronald; Theron, Annette J.; Tintinger, Gregory Ronald (Makerere University Medical School, 2017-09)BACKGROUND : Neutrophil extracellular traps (NETs) constitute a network of chromatin fibres containing histone and antimicrobial peptides that are released by activated neutrophils. NETs protect the host against infection ...
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Anderson, Ronald; Theron, Annette J.; Nel, Jan Gert; Durandt, Chrisna; Cholo, Moloko C.; Feldman, Charles; Tintinger, Gregory Ronald (Frontiers Media, 2018-11-20)Although the inclusion of the cationic amphiphilic, anti-mycobacterial agent, clofazimine, in the chemotherapeutic regimens of patients with multidrug-resistant tuberculosis (TB) has contributed to improved outcomes, ...
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Theron, Annette J.; Steel, Helen C.; Rapoport, Bernardo Leon; Anderson, Ronald (MDPI Publishing, 2020-11-20)Tumor cells are particularly adept at exploiting the immunosuppressive potential of neutrophils as a strategy to achieve uncontrolled proliferation and spread. Recruitment of neutrophils, particularly those of an immature ...
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Theron, Annette J.; Steel, Helen C.; Tintinger, Gregory Ronald; Gravett, Cornelia M.; Anderson, Ronald; Feldman, Charles (Hindawi Publishing Corporation, 2014)Cysteinyl leukotrienes (cysLTs) are produced predominantly by cells of the innate immune system, especially basophils, eosinophils, mast cells, and monocytes/macrophages. Notwithstanding potent bronchoconstrictor activity, ...
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Steel, Helen C.; Venter, Willem Daniel Francois; Theron, Annette J.; Anderson, Ronald; Feldman, Charles; Arulappan, Natasha; Rossouw, Theresa M. (MDPI, 2021-01-29)Systemic biomarkers of inflammation, including cytokines and chemokines, are potentially useful in the management of both HIV infection and non-AIDS-defining disorders. However, relatively little is known about the utility ...
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Madzime, Morris; Theron, Annette J.; Anderson, Ronald; Tintinger, Gregory; Steel, Helen C.; Meyer, Pieter Willem Adriaan; Nel, Jan Gert; Feldman, Charles; Rossouw, Theresa M. (Taylor and Francis, 2022)Please read abstract in the article.
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Opolot, John O.; Theron, Annette J.; MacPhail, Patrick; Feldman, Charles; Anderson, Ronald (Makerere University Medical School, 2017-06)BACKGROUND : Chronic inflammation, possibly exacerbated by cigarette smoking, is considered to be the primary cause of pulmonary damage in patients with tuberculosis (TB). However, the mechanisms which underpin these ...
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Richards, Guy A.; Theron, Annette J.; Tintinger, Gregory Ronald; Anderson, Ronald (MDPI Publishing, 2018-05-14)Dabigatran is an oral direct thrombin inhibitor, and rivaroxaban, a factor Xa inhibitor. Dabigatran has been implicated in the etiology of acute coronary syndromes and as these occur following inflammatory changes in the ...
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Potjo, Moliehi; Cockeran, Riana; Theron, Annette J.; Feldman, Charles; Anderson, Ronald (Molecular Diversity Preservation International, 2010)Moxifloxacin is useful in the treatment of respiratory infections, including community-acquired pneumonia, and also shows promise in the treatment of tuberculosis, a clinical setting which necessitates extended administration ...
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Steel, Helen C.; Venter, Willem Daniel Francois; Theron, Annette J.; Anderson, Ronald; Feldman, Charles; Kwofie-Mensah, M.; Cronje, Tanita; Arullappan, Natasha; Rossouw, Theresa M. (Hindawi Publishing, 2018-12-09)Like HIV infection, smoking, which is common among HIV-infected persons, is associated with chronic, systemic inflammation. However, the possible augmentative effects of HIV infection and smoking and other types of tobacco ...
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Theron, Annette J.; Feldman, Charles; Richards, Guy A.; Tintinger, Gregory Ronald; Anderson, Ronald (AME Publishing Company, 2019-12)Although the usage of electronic (e)-cigarettes (EC) and similar devices has gained in popularity as an apparent smoking cessation strategy, serious concerns are emerging in relation to both the efficacy of this strategy, ...
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Theron, Annette J.; Tintinger, Gregory Ronald; Anderson, Ronald (2012-04-16)In trace amounts, some heavy metals are essential for optimum health, while exposure to others, which are non-essential, presents the potential hazard of acute or chronic organ toxicity. Cadmium, mercury, lead, ...
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Rapoport, Bernardo Leon; Steel, Helen C.; Theron, Annette J.; Heyman, Liezl; Smit, Teresa; Ramdas, Yastira; Anderson, Ronald (MDPI, 2020-07)High mobility group box 1 (HMGB1) is an extremely versatile protein that is located predominantly in the nucleus of quiescent eukaryotic cells, where it is critically involved in maintaining genomic structure and function. ...
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Anderson, Ronald; Theron, Annette J.; Rapoport, Bernardo Leon (Frontiers Media, 2019-09-26)The advent of novel, innovative, and effective anti-cancer immunotherapies has engendered an era of renewed optimism among cancer specialists and their patients. Foremost among these successful immunotherapies are ...
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Madzime, Morris; Rossouw, Theresa M.; Theron, Annette J.; Anderson, Ronald; Steel, Helen C. (MDPI, 2021-03-12)Neutrophils are important components of the innate immune system that mediate pathogen defense by multiple processes including phagocytosis, release of proteolytic enzymes, production of reactive oxygen species, and ...
Now showing items 1-20 of 40