Browsing Health Sciences by Title

Browsing Health Sciences by Title

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  • Eyal, A.S.; Kemp, M.; Luvhengo, T. (Elsevier, 2007-05)
    Kalafong Hospital is a secondary hospital situated to the west of Pretoria. It serves as the regional burns centre for Gauteng province north of the Jukskei river. It mainly serves a poor population. This is a retrospective ...
  • Lilian, R.P.; Mutasa, B.; Railton, J.; Mongwe, W.; McIntyre, J.A.; Struthers, H.E.; Peters, Remco P.H. (Cambridge University Press, 2017-01)
    South Africa’s paediatric antiretroviral therapy (ART) programme is managed using a monitoring and evaluation tool known as TIER.Net. This electronic system has several advantages over paper-based systems, allowing ...
  • Oldekop, Johan A.; Fontana, Lorenza B.; Grugel, Jean; Roughton, Nicole; Adu-Ampong, Emmanuel A.; Bird, Gemma K.; Alex, Dorgan; Espinoza, Marcia A. Vera; Wallin, Sara; Hammett, Daniel; Agbarakw, Esther; Agrawal, Arun; Asylbekova, Nurgul; Azkoul, Clarissa; Bardsley, Craig; Bebbington, Anthony J.; Carvalho, Savio; Chopra, Deepta; Christopoulos, Stamatios; Crewe, Emma; Marie-Claude, Dop; Fischer, Joern; Gerretsen, Daan; Glennie, Jonathan; Gois, William; Gondwe, Mtinkheni; Harrison, Lizz A.; Hujo, Katja; Keen, Mark; Laserna, Roberto; Miggiano, Luca; Mistry, Sarah; Morgan, Rosemary J.; Raftree, Linda L.; Rhind, Duncan; Rodrigues, Thiago; Roschnik, Sonia; Senkubuge, Flavia; Thornton, Ian; Trace, Simon; Ore, Teresa; Vald es, Ren e Mauricio; Vira, Bhaskar; Yeates, Nicola; Sutherland, William J. (Wiley, 2016-01)
    The Sustainable Development Goals (SDGs) herald a new phase for international development. This article presents the results of a consultative exercise to collaboratively identify 100 research questions of critical importance ...
  • Visagie, M.H. (Michelle Helen); Birkholtz, Lyn-Marie; Joubert, Annie M. (Wiley, 2014)
    Microtubules are important targets when studying potential anticancer agents since disturbance of these microtubule dynamics results in cell cycle arrest and cell death. 2-Methoxyestradiol is a naturally occurring metabolite ...
  • Visagie, M.H. (Michelle Helen); Birkholtz, Lyn-Marie; Joubert, Annie M. (BioMed Central, 2015-04-22)
    INTRODUCTION : Research involving antimitotic compounds identified 2-methoxyestradiol (2ME2), as a promising anticancer endogenous metabolite. Owing to its low bioavailability, several in silico-designed 2ME2 analogues ...
  • Visagie, M.H. (Michelle Helen); Joubert, Annie M. (Springer, 2011-11)
    In anticancer research where the focus is on finding agents that induces cell death while leaving nontumorigenic cells less affected, a novel 2-methoxyestradiol derivative has come forth. 2-Methoxyestradiol-bis-sulfam ...
  • Mqoco, T.V. (Thandi Vuyelwa); Marais, Sumari; Joubert, Annie M. (Biomedical Research Press, 2013)
    2-Methoxyestradiol-bis-sulphamate (2-MeOE2bisMATE) is a bis-sulphamoylated analogue of a biological estradiol metabolite, 2-methoxyestradiol (2ME2) with potential as an anticancer drug. The aim of this in vitro study was ...
  • Visagie, M.H. (Michelle Helen); Joubert, Annie M. (BioMed Central, 2012-08-20)
    BACKGROUND: Anticancer research resulted in the discovery of a promising antimitotic metabolite, 2-methoxyestradiol. 2-Methoxyestradiol-bis-sulphamate, a bis-sulphamoylated analogue exerts antiproliferative- and antimitotic ...
  • Marais, Sumari; Stander, Barend Andre; Joubert, Annie M. (AOSIS Open Journals, 2013)
    2-MEBM induced apoptosis and autophagy in HeLa cells and also disrupted the cellular microtubule network. This contributes to the understanding of the in vitro mechanism of action of 2MEBM as a potential anticancer drug.
  • Mqoco, T.V. (Thandi Vuyelwa); Marais, Sumari; Joubert, Annie M. (Suid Afrikaanse Akademie vir Wetenskap & Kuns, 2012)
    Future in vitro studies into the mechanism of this potentially anticancer drug are warranted.
  • Sathekge, Mike Machaba; Knoesen, Otto; Meckel, Marian; Modiselle, Moshe; Vorster, Mariza; Marx, Sebastian (Springer, 2017-06)
    Prostate-specific membrane antigen radioligand therapy (PSMA-RLT) with 177Lu-PSMA holds great promise as a safe treatment option in patients with metastasized castration-resistant prostate cancer (mCRPC) with ...
  • Soma-Pillay, Priya; Lombaard, H.A.D.T. (Hennie) (In House Publications, 2010)
    No abstract available.
  • Wortmann, Saskia B.; Kluijtmans, Leo A. J.; Rodenburg, Richard J.; Sass, Jörn Oliver; Nouws, Jessica; Van Kaauwen, Edwin P.; Kleefstra, Tjitske; Tranebjaerg, Lisbeth; De Vries, Maaike C.; Isohanni, Pirjo; Walter, Katharina; Alkuraya, Fowzan S.; Smuts, Izelle; Reinecke, Carolus J.; an der Westhuizen, Francois Hendrikus; Thorburn, David; Smeitink, Jan A.M.; Morava, Eva; Wevers, Ron A. (Springer, 2013-11)
    Elevated urinary excretion of 3-methylglutaconic acid is considered rare in patients suspected of a metabolic disorder. In 3-methylglutaconyl-CoA hydratase deficiency (mutations in AUH), it derives from leucine degradation. ...
  • Kotze, Carla; De Wet, P.H. (Paul Henry) (Health and Medical Publishing Group, 2011-12)
    OBJECTIVE: The objective was to review psychiatric involvement in seven prosecutorial workshops on criminal capacity between 2004 and 2009. The aim was to evaluate the changing role of the psychiatrists in the workshops ...
  • Green, Robin J. (Medpharm Publications, 2015)
    Apart from medication to control asthmatic inflammation, the education of patients and parents is the most important therapeutic step in achieving asthma control and normal life. This is a critical, but sadly often ...
  • Sathekge, Mike Machaba; Lengana, Thabo; Maes, Alex; Vorster, Mariza; Zeevaart, Jan Rijn; Lawal, Ismaheel; Ebenhan, Thomas; Van de Wiele, Christophe (Springer, 2018-02)
    PURPOSE : The incidence of prostate cancer is 60% higher and the mortality rate is two- to three-times greater in black versus white men. We report on differences in 68Ga-PSMA-11 PET/CT imaging findings in 77 black ...
  • Sathekge, Mike Machaba; Lengana, Thabo; Modiselle, Moshe; Vorster, Mariza; Zeevaart, Jan Rijn; Maes, Alex; Ebenhan, Thomas; Van de Wiele, Christophe (Springer, 2017-04)
    BACKGROUND : To report on imaging findings using 68Ga-PSMAHBED- CC PET in a series of 19 breast carcinoma patients. METHODS : 68Ga-PSMA-HBED-CC PET imaging results obtained were compared to routinely performed staging ...
  • De Kock, J.; Heyns, Tanya; Van Rensburg, Gisela H. (Medpharm Publications, 2008)
    Haemorrhagic shock is more common in the pregnant woman than generally acknowledged in the clinical setting. In most cases antepartum and postpartum haemorrhage can be managed effectively by concentrating on the management ...
  • Van der Westhuizen, Francois Hendrikus; Smet, Joel; Levanets, Oksana; Meissner-Roloff, Madelein; Louw, Roan; Van Coster, Rudy; Smuts, Izelle (Springer, 2010-01)
    A young, adult, African male patient presented with progressive proximal muscle weakness, external ophthalmoplegia and ptosis, as well as cardiac conduction abnormalities resembling Kearns–Sayre syndrome (KSS). Magnetic ...
  • Snyman, Leon C. (Open Journals Systems, 2013)
    In 2009, The Cancer Association of South Africa (CANSA) awarded its biggest research grant to date to the HPV Cervical Cancer Research Fund, under the auspices of Prof Greta Dreyer. This grant enabled a group of researchers ...