A 10-year cohort analysis of routine paediatric ART data in a rural South African setting
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Date
Authors
Lilian, R.P.
Mutasa, B.
Railton, J.
Mongwe, W.
McIntyre, J.A.
Struthers, H.E.
Peters, Remco P.H.
Journal Title
Journal ISSN
Volume Title
Publisher
Cambridge University Press
Abstract
South Africa’s paediatric antiretroviral therapy (ART) programme is managed using a
monitoring and evaluation tool known as TIER.Net. This electronic system has several
advantages over paper-based systems, allowing profiling of the paediatric ART programme over
time. We analysed anonymized TIER.Net data for HIV-infected children aged <15 years who
had initiated ART in a rural district of South Africa between 2005 and 2014. We performed
Kaplan–Meier survival analysis to assess outcomes over time. Records of 5461 children were
available for analysis; 3593 (66%) children were retained in care. Losses from the programme
were higher in children initiated on treatment in more recent years (P < 0·0001) and in children
aged ≤1 year at treatment initiation (P < 0·0001). For children aged <3 years, abacavir was
associated with a significantly higher rate of loss from the programme compared to stavudine
(hazard ratio 1·9, P < 0·001). Viral load was suppressed in 48–52% of the cohort, with no
significant change over the years (P = 0·398). Analysis of TIER.Net data over time provides
enhanced insights into the performance of the paediatric ART programme and highlights
interventions to improve programme performance.
Description
Keywords
Analysis of data, HIV/AIDS, Paediatrics, Public health, Human immunodeficiency virus (HIV), Acquired immune deficiency syndrome (AIDS), Antiretroviral therapy (ART)
Sustainable Development Goals
Citation
Lilian, RR, Mutasa, B, Railton, J, Mongwe, W, McIntyre, JA, Struthers, HE & Peters, RPH 2016, 'A 10-year cohort analysis of routine paediatric ART data in a rural South African setting', Epidemiology and Infection, vol. 145, no. 1, pp. 170-180.