Expression of the H-subunit and L-subunit of ferritin in bone marrow macrophages and cells of the erythron during cellular immune activation
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| dc.contributor.author | Koorts, Alida Maria
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| dc.contributor.author | Levay, Peter Ferenc
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| dc.contributor.author | Hall, Alan N.
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| dc.contributor.author | Van der Merwe, Christiaan F.
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| dc.contributor.author | Becker, Piet J.
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| dc.contributor.author | Viljoen, Margaretha
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| dc.date.accessioned | 2011-06-13T09:30:04Z | |
| dc.date.available | 2011-06-13T09:30:04Z | |
| dc.date.issued | 2011-05 | |
| dc.description.abstract | BACKGROUND: The expression of the two types of ferritin subunits, the H-subunit and L-subunit, has been shown to be differentially regulated by cytokines. The primary aim of the present study was to quantitatively measure the expression of the H-subunit and L-subunit of ferritin in bone marrow macrophages and cells of the erythron in patients with chronic T-helper cell type-1 immune stimulation. METHODS: The expression of the H-subunit and L-subunit of ferritin in bone marrow macrophages and cells of the erythron was quantitatively evaluated by post-embedding immunolocalisation with immunogold transmission electron microscopy. RESULTS: The present study showed up-regulation of the H-subunit of ferritin in the bone marrow macrophage in patients with pronounced cellular immune activation (94.7 ± 37.3 counts/μm2; n = 31 vs 72.4 ± 34.0 counts/μm2; n = 13, p-value = 0.037). CONCLUSION: This supports a possible role for H-subunit rich ferritins in the hypoferraemia of chronic disease. | en_US |
| dc.identifier.citation | A.M. Koorts, et al., Expression of the H-subunit and L-subunit of ferritin in bone marrow macrophages and cells ofthe erythron during cellular immune activation, Blood Cells Mol. Diseases (2011), doi:10.1016/j.bcmd.2011.04.006 | en_US |
| dc.identifier.issn | 1079-9796 (print) | |
| dc.identifier.issn | 1096-0961 (online) | |
| dc.identifier.other | 10.1016/j.bcmd.2011.04.006 | |
| dc.identifier.uri | http://hdl.handle.net/2263/16806 | |
| dc.language.iso | en | en_US |
| dc.publisher | Elsevier | en_US |
| dc.rights | © 2011 Elsevier Inc. All rights reserved. | en_US |
| dc.subject | Ferritin | en_US |
| dc.subject | Isoferritins | en_US |
| dc.subject | H-subunit | en_US |
| dc.subject | L-subunit | en_US |
| dc.subject | Iron | en_US |
| dc.subject | Cellular immune activation | en_US |
| dc.subject.lcsh | Molecular immunology -- South Africa | en |
| dc.title | Expression of the H-subunit and L-subunit of ferritin in bone marrow macrophages and cells of the erythron during cellular immune activation | en_US |
| dc.type | Postprint Article | en_US |
