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Browsing Research Articles (Veterinary Tropical Diseases) by Author "Santema, Wiebren J."

Now showing items 1-5 of 5

Hsp70 vaccination-induced antibodies recognize B cell epitopes in the cell wall of Mycobacterium avium subspecies paratuberculosis

Santema, Wiebren J.; Van Kooten, Peter; Hoek, Aad; Leeflang, Mariska; Overdijk, Marije; Rutten, Victor P.M.G.; Koets, Ad P. (Elsevier, 2011-02)

Mycobacterium avium subspecies paratuberculosis (MAP) causes a chronic intestinal infection of ruminants and has been associated with the etiology of human Crohn's disease. A MAP Hsp70/DDA subunit vaccine previously showed ...
Immune response of cattle immunized with a conjugate of the glycolipid glucose monomycolate and protein

Nguyen, Thi Kim Anh; Wieland, Willemien; Santema, Wiebren J.; Hoeboer, Jeroen; Van Eden, Willem; Rutten, Victor P.M.G.; Koets, Ad P.; Van Rhijn, Ildiko (Elsevier, 2011-08)

Strong anti glycolipid IgG responses can occur in humans and animals, but contrary to anti protein responses and anti glycoprotein responses, the exact mechanism of induction is unknown. We have previously shown that ...
The mycobacterial glycolipid glucose monomycolate induces a memory T cell response comparable to a model protein antigen and no B cell response upon experimental vaccination of cattle

Nguyen, Thi Kim Anh; Koets, Ad P.; Santema, Wiebren J.; Van Eden, Willem; Rutten, Victor P.M.G.; Van Rhijn, Ildiko (Elsevier, 2009)

Glycolipids are presented to T cells by human group 1 CD1 proteins, but are not used as subunit vaccines yet. Experimental immunizations with pure mycobacterial glucose monomycolate (GMM) and keyhole limpet haemocyanin ...
Postexposure subunit vaccination against chronic enteric mycobacterial infection in a natural host

Santema, Wiebren J.; Rutten, Victor P.M.G.; Segers, Ruud; Poot, Jacqueline; Hensen, Selma; Heesterbeek, Hans; Koets, Ad P.; Flynn, J.L. (2013-06)

The control of chronic bacterial diseases with high prevalence in areas of endemicity would strongly benefit from availability of postexposure vaccines. The development of these vaccines against mycobacterial infections, ...
Susceptibility to paratuberculosis infection in cattle is associated with single nucleotide polymorphisms in Toll-like receptor 2 which modulate immune responses against Mycobacterium avium subspecies paratuberculosis

Koets, Ad P.; Santema, Wiebren J.; Mertens, H.; Oostenrijk, D.; Keestra, M.; Overdijk, Marije; Labouriau, R.; Franken, P.; Frijters, A.; Nielen, Mirjam; Rutten, Victor P.M.G. (Elsevier, )

Paratuberculosis is a chronic intestinal infection in ruminants, caused by Mycobacterium avium subspecies paratuberculosis (Map). To study the role of host genetics in disease susceptibility, the Toll-like receptor 2 ...

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Browsing Research Articles (Veterinary Tropical Diseases) by Author "Santema, Wiebren J."

Browsing Research Articles (Veterinary Tropical Diseases) by Author "Santema, Wiebren J."

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