Preclinical assessment addressing intravenous administration of a [68Ga]Ga-PSMA-617 microemulsion : acute in vivo toxicity, tolerability, PET imaging, and biodistribution
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| dc.contributor.author | Mandiwana, Vusani
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| dc.contributor.author | Kalombo, Lonji
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| dc.contributor.author | Hayeshi, Rose
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| dc.contributor.author | Zeevaart, Jan Rijn
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| dc.contributor.author | Ebenhan, Thomas
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| dc.date.accessioned | 2021-12-01T10:16:08Z | |
| dc.date.available | 2021-12-01T10:16:08Z | |
| dc.date.issued | 2021-04-30 | |
| dc.description.abstract | It has been herein presented that a microemulsion, known to be an effective and safe drug delivery system following intravenous administration, can be loaded with traces of [68Ga]Ga-PSMA- 617 without losing its properties or causing toxicity. Following tolerated IV injections the capability of the microemulsion in altering [68Ga]Ga-PSMA-617 distribution was presented at 120 min post injection based on its ex vivo biodistribution results. | en_ZA |
| dc.description.department | Nuclear Medicine | en_ZA |
| dc.description.librarian | am2021 | en_ZA |
| dc.description.sponsorship | The Nuclear Technologies in Medicine and the Biosciences Initiative (NTeMBI) is funded by the Department of Science and Technology, the Department of Nuclear Medicine, University of Pretoria and the Council for Scientific and Industrial Research and the Carl and Emily Fuchs Foundation. | en_ZA |
| dc.description.uri | http://www.mdpi.com/journal/molecules | en_ZA |
| dc.identifier.citation | Mandiwana, V.; Kalombo, L.; Hayeshi, R.; Zeevaart, J.R.; Ebenhan, T. Preclinical Assessment Addressing Intravenous Administration of a [68Ga]Ga-PSMA-617 Microemulsion: Acute In Vivo Toxicity, Tolerability, PET Imaging, and Biodistribution. Molecules 2021, 26, 2650. https://DOI.org/ 10.3390/molecules26092650. | en_ZA |
| dc.identifier.issn | 1420-3049 (print) | |
| dc.identifier.issn | 1420-3049 (online) | |
| dc.identifier.other | 10.3390/molecules26092650 | |
| dc.identifier.uri | http://hdl.handle.net/2263/82928 | |
| dc.language.iso | en | en_ZA |
| dc.publisher | MDPI Publishing | en_ZA |
| dc.rights | © 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license. | en_ZA |
| dc.subject | Biodistribution | en_ZA |
| dc.subject | 68Ga | en_ZA |
| dc.subject | [68Ga]Ga-PSMA-617-ME | en_ZA |
| dc.subject | In vivo | en_ZA |
| dc.subject | Microemulsion | en_ZA |
| dc.subject | MicroPET/CT | en_ZA |
| dc.subject | Prostate cancer | en_ZA |
| dc.subject | PSMA-617 | en_ZA |
| dc.subject | Toxicity | en_ZA |
| dc.title | Preclinical assessment addressing intravenous administration of a [68Ga]Ga-PSMA-617 microemulsion : acute in vivo toxicity, tolerability, PET imaging, and biodistribution | en_ZA |
| dc.type | Article | en_ZA |
