Van de Wiele, Christophe; Bracke, Nathalie; Wynendaele, Evelien; D’Hondt, Matthias; Haselberg, Rob; Somsen, Govert W.; Pauwels, Ewald; De Spiegeleer, Bart(Elsevier, 2014-08)
Chemical modification of biomolecules like the introduction of metal-chelators into proteins can lead
to heterogeneous product formation. The nature and extend of the modification is important in
interpreting the biological ...
Van de Wiele, Christophe; Wynendaele, Evelien; Verbeke, Frederick; D’Hondt, Matthias; Hendrix, An; Burvenich, Christian; Peremans, Kathelijne; De Wever, Olivier; Bracke, Marc; De Spiegeleer, Bart(Elsevier, 2015-02)
To date, the precise role of the human microbiome in health and disease states remains largely
undefined. Complex and selective crosstalk systems between the microbiome and mammalian
cells are also not yet reported. ...
Sathekge, Mike Machaba; Mandiwana, Vusani; Kalombo, Lonji; Venter, Kobus; Grobler, Anne; Zeevaart, Jan Rijn(Springer, 2015-09)
Developing nanoparticulate delivery systems
that will allow easy movement and localization
of a drug to the target tissue and provide more
controlled release of the drug in vivo is a challenge in
nanomedicine. The aim ...
Van de Wiele, Christophe; De Spiegeleer, Bart; Verbeke, Frederick; D’Hondt, Matthias; Hendrix, An; Burvenich, Christian; Peremans, Kathelijne; De Wever, Olivier; Bracke, Marc; Wynendaele, Evelien(Public Library of Science, 2015-03-17)
The role of the human microbiome on cancer progression remains unclear. Therefore, in
this study, we investigated the influence of some quorum sensing peptides, produced by diverse
commensal or pathogenic bacteria, on ...
Ankrah, Alfred O.; Sathekge, Mike Machaba; Glaudemans, Andor W.J.M.; Klein, Hans C.(SpringerOpen, 2016-04)
In a previous paper, an overview of the use of PET/CT in
the management of tuberculosis (TB) was provided and the
potential role of nitroimidazole imaging in LTBI was
considered . During latent TB, dormant bacilli ...
Lawal, Ismaheel; Vorster, Mariza; Boshomane, Tebatso; Ololade, Kehinde; Ebenhan, Thomas; Sathekge, Mike Machaba(Lippincott Williams and Wilkins, 2015-09)
We describe the finding of a metastatic superscan detected by Ga-PSMA PET/CT imaging. A 63-year-old man with metastatic prostate carcinoma underwent Ga-PSMA PET/CT imaging for staging and evaluation of the most appropriate ...
Vorster, Mariza; Nyakale, Nozipho E.; Sathekge, Mike Machaba; Doruyter, A.; Brink, A.; Mkhize, S.; Holness, J.; Malan, N.; Warwick, J.M.(Health and Medical Publishing Group, 2016-01)
These recommendations are intended to serve an important and relevant role in advising referring physicians on the appropriate use
of 18F-fluorodeoxyglucose (18F-FDG) and non-18F-FDG positron emission tomography/computed ...
Buscombe, J.R. (John Richard)(British Institute of Radiology, 2015)
Positron emission tomography (PET) has become widely established in oncology. Subsequently, a whole new “toolbox” of
tracers have become available to look at different aspects of cancer cell function and dysfunction, ...
Prostate-specific membrane antigen (PSMA), a type II glycoprotein, is highly
expressed in almost all prostate cancers. By playing such a universal role in the disease,
PSMA provides a target for diagnostic imaging of ...
Mokaleng, Botshelo B.; Ebenhan, Thomas; Zeevaart, Jan Rijn; Sathekge, Mike Machaba; Ramesh, Suhas; Govender, Thavendran; Kruger, Hendrik G.; Parboosing, Raveen; Hazari, Puja P.; Mishra, Anil K.; Marjanovic-Painter, Biljana(Hindawi Publishing, 2015)
Noninvasive imaging is a powerful tool for early diagnosis and monitoring of various disease processes, such as infections. An alarming shortage of infection-selective radiopharmaceuticals exists for overcoming the diagnostic ...
Vorster, Mariza; Sathekge, Mike Machaba; Bomanji, Jamshed(Lippincott Williams and Wilkins, 2014-05)
PURPOSE OF REVIEW : To review the main applications, advantages and limitations of 18F-FDG PET and PET/computed
tomography (CT), and some other tracers in imaging of tuberculosis (TB).
RECENT FINDINGS : In pulmonary TB, ...
Maes, Alex; Sathekge, Mike Machaba; Van de Wiele, Christophe; Hudyana, Hendrah; Vandenberghe, Thierry; Fidlers, Luc; Nicolai, Daniel(Springer, 2016-02)
BACKGROUND : The aim of this retrospective study was to evaluate
the accuracy of bone SPECT (single photon emission computed
tomography)/CT (computed tomography) in diagnosing
loosening of fixation material in patients ...
Sathekge, Mike Machaba; Vorster, Mariza; Warwick, J.M.; Doruyter, A.(Health and Medical Publishing Group, 2015-11)
Individualised patient treatment approaches demand precise determination of initial disease extent combined with early, accurate
assessment of response to treatment, which is made possible by positron emission tomography/computed ...
Vorster, Mariza; Maes, Alex; Van de Wiele, Christophe; Sathekge, Mike Machaba; Jacobs, Aldrich; Malefahlo, Sidney; Pottel, Hans(Springer, 2014-07)
We sought to determine whether PET/CT
imaging with 68Ga-citrate could be of value in distinguishing
benign from malignant lung pathology in a setting
with a high prevalence of granulomatous diseases.
METHODS : ...
Ebenhan, Thomas; Zeevaart, Jan Rijn; Sathekge, Mike Machaba; Gheysens, Olivier; Kruger, Hendrik G.(Hindawi Publishing, 2014-08)
Antimicrobial peptides (AMPs) are a heterogeneous class of compounds found in a variety of organisms including humans and,
so far, hundreds of these structures have been isolated and characterised. They can be described ...
Nyakale, Nozipho E.; Lockhat, Zarina I.; Lockhat, Zarina I.(Allergy Society of South Africa, 2015-03)
Immunologic reactions to radiopharmaceuticals are usually mild and transient and require little or no medical
treatment. As the usage of radiopharmaceuticals has increased, the reported adverse reactions remain ...
Bresser, Philippa; De Beer, Janeske; De Wet, Yolandi(Elsevier, 2015-02)
PURPOSE : A planar multi-gated cardiac blood pool acquisition is a non-invasive technique commonly used to measure left ventricular ejection fraction (LVEF). It is essential that the calculation of LVEF be accurate, ...
Maes, Alex; Van de Wiele, Christophe; Kruse, Vibeke; Cocquyt, Veronique; Borms, Marleen(Springer, 2013-02)
When confronted with a suspicious rise in CA
15.3 in asymptomatic breast cancer patients following
primary treatment and negative or equivocal conventional
imaging findings, FDG PET/CT allows assessment of the
site and ...
Ebenhan, Thomas; Zeevaart, Jan Rijn; Sathekge, Mike Machaba; Venter, Jacobus D.; Govender, Thavendran; Kruger, Gert H.; Jarvis, Neil V.(Society of Nuclear Medicine, 2014-02)
Antimicrobial peptides such as ubiquicidin (UBI) are believed to differentiate between mammalian and bacterial or fungal cells. (99m)Tc-UBI29-41 was previously tested for detecting infection in humans using SPECT. For the ...
Buscombe, J.R. (John Richard); Jamar, Francois; Chiti, Arturo; Christian, Paul E.; Delbeke, Dominique; Donohoe, Kevin J.; Israel, Ora; Martin-Comin, Josep; Signore, Alberto(Society of Nuclear Medicine, Inc., 2013-01-28)
The Society of Nuclear Medicine and Molecular Imaging
(SNMMI) is an international scientific and professional
organization founded in 1954 to promote the science,
technology and practical application of nuclear ...