dc.contributor.author |
Van Hooft, Pim
|
|
dc.contributor.author |
Dougherty, Eric R.
|
|
dc.contributor.author |
Getz, Wayne Marcus
|
|
dc.contributor.author |
Greyling, Barend Jacobus
|
|
dc.contributor.author |
Zwaan, Bas J.
|
|
dc.contributor.author |
Bastos, Armanda D.S.
|
|
dc.date.accessioned |
2018-03-28T09:00:09Z |
|
dc.date.available |
2018-03-28T09:00:09Z |
|
dc.date.issued |
2018-02-07 |
|
dc.description |
S1 Fig. Map with locations of the rainfall stations and the sampled herds. |
en_ZA |
dc.description |
S2 Fig. Regression between fraction HBC among BTB-negative females and BTB prevalence
per herd. |
en_ZA |
dc.description |
S1 Table. Logistic regression southern females with body condition status as dependent
variable (highest ranking model). |
en_ZA |
dc.description |
S2 Table. Logistic regression southern males with body condition status as dependent variable
(highest ranking model). |
en_ZA |
dc.description |
S3 Table. Logistic regression southern females with BTB status as dependent variable
(highest ranking model). |
en_ZA |
dc.description |
S4 Table. Logistic regression southern males with BTB status as dependent variable (highest
ranking model). |
en_ZA |
dc.description |
S5 Table. Logistic regression northern females with body condition status as dependent
variable (highest ranking model). |
en_ZA |
dc.description |
S6 Table. Logistic regression southern males with BTB status as dependent variable (Evidence
Ratio = 1.9). |
en_ZA |
dc.description |
S7 Table. Logistic regression northern males with body condition status as dependent variable
(Evidence Ratio = 2.1). |
en_ZA |
dc.description |
S8 Table. Significance of the genetic-measure by annual-rainfall interaction per single
year. |
en_ZA |
dc.description |
S9 Table. Logistic regression northern females with body condition status as dependent
variable (Evidence Ratio = 1.8). |
en_ZA |
dc.description |
S10 Table. Results Hedges' g analyses (group differences with respect to MDLmale and
MDLfemale). |
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dc.description |
S1 Text. Consistency of the model outcomes. |
en_ZA |
dc.description.abstract |
In the African buffalo (Syncerus caffer) population of the Kruger National Park (South Africa) a
primary sex-ratio distorter and a primary sex-ratio suppressor have been shown to occur on
the Y chromosome. A subsequent autosomal microsatellite study indicated that two types of
deleterious alleles with a negative effect on male body condition, but a positive effect on relative
fitness when averaged across sexes and generations, occur genome-wide and at high frequencies
in the same population. One type negatively affects body condition of both sexes,
while the other acts antagonistically: it negatively affects male but positively affects female
body condition. Here we show that high frequencies of male-deleterious alleles are attributable
to Y-chromosomal distorter-suppressor pair activity and that these alleles are suppressed in
individuals born after three dry pre-birth years, likely through epigenetic modification. Epigenetic
suppression was indicated by statistical interactions between pre-birth rainfall, a proxy for
parental body condition, and the phenotypic effect of homozygosity/heterozygosity status of
microsatellites linked to male-deleterious alleles, while a role for the Y-chromosomal distortersuppressor
pair was indicated by between-sex genetic differences among pre-dispersal
calves. We argue that suppression of male-deleterious alleles results in negative frequencydependent
selection of the Y distorter and suppressor; a prerequisite for a stable polymorphism
of the Y distorter-suppressor pair. The Y distorter seems to be responsible for positive
selection of male-deleterious alleles during resource-rich periods and the Y suppressor for
positive selection of these alleles during resource-poor periods. Male-deleterious alleles were
also associated with susceptibility to bovine tuberculosis, indicating that Kruger buffalo are
sensitive to stressors such as diseases and droughts. We anticipate that future genetic studies on African buffalo will provide important new insights into gene fitness and epigenetic modification
in the context of sex-ratio distortion and infectious disease dynamics. |
en_ZA |
dc.description.department |
Mammal Research Institute |
en_ZA |
dc.description.department |
Zoology and Entomology |
en_ZA |
dc.description.librarian |
am2018 |
en_ZA |
dc.description.sponsorship |
Laboratory analyses were supported by
US NIH/NSF Ecology of Infectious Disease Grant
GM83863 awarded to WMG. |
en_ZA |
dc.description.uri |
http://www.plosone.org |
en_ZA |
dc.identifier.citation |
Van Hooft P, Dougherty ER, Getz WM,
Greyling BJ, Zwaan BJ, Bastos ADS (2018) Genetic
responsiveness of African buffalo to environmental
stressors: A role for epigenetics in balancing
autosomal and sex chromosome interactions?
PLoS ONE 13(2): e0191481. https://DOI.org/
10.1371/journal.pone.0191481. |
en_ZA |
dc.identifier.issn |
1932-6203 (online) |
|
dc.identifier.other |
10.1371/journal.pone.0191481 |
|
dc.identifier.uri |
http://hdl.handle.net/2263/64327 |
|
dc.language.iso |
en |
en_ZA |
dc.publisher |
Public Library of Science |
en_ZA |
dc.rights |
© 2018 van Hooft et al. This is an open
access article distributed under the terms of the
Creative Commons Attribution License, |
en_ZA |
dc.subject |
Infectious disease |
en_ZA |
dc.subject |
African buffalo (Syncerus caffer) |
en_ZA |
dc.subject |
Kruger National Park (KNP) |
en_ZA |
dc.subject |
Kruger National Park (South Africa) |
en_ZA |
dc.subject |
Sex-ratio distortion |
en_ZA |
dc.subject |
Bovine tuberculosis (bTB) |
en_ZA |
dc.title |
Genetic responsiveness of African buffalo to environmental stressors : a role for epigenetics in balancing autosomal and sex chromosome interactions? |
en_ZA |
dc.type |
Article |
en_ZA |