Abstract:
Enterobacteriaceae with blaNDM-7 is relatively uncommon and had previously been described in
Europe, India, USA and Japan. This study describes the characteristics of Enterobacteriaceae
[Klebsiella pneumoniae (n=2), Escherichia coli (n=2), Serratia marcescens (n=1), Enterobacter
hormaechei (n=1)] with blaNDM-7 obtained in 4 patients from Calgary, Canada during 2013-4.
The 46,161 bp IncX3 plasmids with blaNDM-7 are highly similar to other blaNDM-harboring IncX3
plasmids and interestingly, showed identical structures within the different isolates. This finding
may indicate horizontal transmission within our health region or may indicate contact with
individuals from endemic areas within the hospital setting. Patients infected or colonized with
bacteria containing blaNDM-7 IncX3 plasmids will generate infection control challenges.
Epidemiological and molecular studies are required to better understand the dynamics of
transmission, risk factors and reservoirs for bacteria harboring blaNDM-7. To the best of our
knowledge, this is the first report of S. marcescens, and E. hormaechei with blaNDM-7.
