Research Articles (Medical Microbiology)

Research Articles (Medical Microbiology)

 

Recent Submissions

  • Mayaphi, Simnikiwe H.; Martin, Desmond J.; Tintinger, Gregory Ronald; Stoltz, Anton Carel; Quinn, Thomas C.; Laeyendecker, Oliver (Public Library of Science, 2016-10-20)
    BACKGROUND: Two thirds of the world's new HIV infections are in sub-Saharan Africa. Acute HIV infection (AHI) is the time of virus acquisition until the appearance of HIV antibodies. Early HIV infection, which includes ...
  • Ismail, Nazir Ahmed; Earle, Sarah G.; Wu, Chieh-Hsi; Charlesworth, Jane; Stoesser, Nicole; Gordon, N. Claire; Walker, Timothy M.; Spencer, Chris C.A.; Iqbal, Zamin; Clifton, David A.; Hopkins, Katie L.; Woodford, Neil; Smith, E. Grace; Llewelyn, Martin J.; Peto, Tim E.; Crook, Derrick W.; McVean, Gil; Walker, A. Sarah; Wilson, Daniel J. (Springer Nature, 2016-04-04)
    Bacteria pose unique challenges for genome-wide association studies because of strong structuring into distinct strains and substantial linkage disequilibrium across the genome1,2. Although methods developed for human ...
  • Ismail, Nazir Ahmed; Koser, Claudio U.; Javid, Babak; Ellington, Matthew J.; Feveriegel, Silke; Niemann, Stefan; Brown, Nicolas M.; Burman, William J.; Abubakar, Ibrahim; Moore, David; Peacock, Sharon J.; Torok, M.Estee (Elsevier, 2015-01)
    Bedaquiline and delamanid, novel classes of anti-tuberculosis drugs, have been recently approved for the treatment of multidrug-resistant tuberculosis. Antimicrobial resistance invariably follows the introduction of ...
  • Omar, S.V. (Shaheed Vally); Peters, Remco P.H.; Ismail, Nazir Ahmed; Fourie, P.B. (Petrus Bernardus); Dreyer, Andries W.; Jonkman, Kelly; Said, Halima M.; Gwalab, Thabisile; Ismail, Nabila (Wiley, 2016-06)
    Molecular tests are revolutionizing diagnosis of tuberculosis (TB). Disease burden is concentrated in resource-poor countries with inadequate infrastructure and capacity resulting in delays for specimens to reach the ...
  • Ebrahim, Osman; Rohr, Julia K.; Ive, Prudence; Horsburgh, C. Robert; Berhanu, Rebecca; Shearer, Kate; Maskew, Mhairi; Long, Lawrence; Sanne, Ian; Bassett, Jean; Fox, Matthew P. (Public Library of Science, 2016-08-22)
    BACKGROUND South African HIV treatment guidelines call for patients who fail first-line antiretroviral therapy (ART) to be switched to second-line ART, yet logistical issues, clinician decisions and patient preferences ...
  • Hoosen, Anwar Ahmed; Green, Ezekiel; Obi, Lawrence C.; Okoh, Anthony I.; Nchabeleng, Maphoshane; De Villiers, Babsie E.; Letsoalo, Tomas; Bessong, Pascal O.; Ndip, Roland N. (BioMed Central, 2013-03)
    Tuberculosis (TB) remains a deadly infectious disease affecting millions of people worldwide; 95% of TB cases, with 98% of death occur in developing countries. The situation in South Africa merits special attention. A ...
  • Peters, Remco P.H.; Dubbink, Jan Henk; Van der Eem, Lisette; McIntyre, James A.; Mbambazela, Nontembeko; Jobson, Geoffrey A.; Ouburg, Sander; Morre, Servaas A.; Struthers, Helen E. (BioMed Central, 2016-07-12)
    BACKGROUND : Sexual behaviour is a core determinant of the HIV and sexually transmitted infection (STI) epidemics in women living in rural South Africa. Knowledge of sexual behaviour in these areas is limited, but ...
  • Pitout, Johann D.D.; Matsumura, Yasufumi (Taylor and Francis, 2016-07)
    Carbapenemase-producing Enterobacteriaceae (CPE), mainly Klebsiella pneumoniae and Escherichia coli, have been increasing rapidly on a global scale and are considered to be significant health threats. The most common ...
  • Mans, Janet; Taylor, Maureen B.; Armah, George E.; Steele, A. Duncan (Public Library of Science, 2016-04-26)
    Norovirus (NoV) is recognised as a leading cause of gastroenteritis worldwide across all age groups. The prevalence and diversity of NoVs in many African countries is still unknown, although early sero-prevalence studies ...
  • Ismail, Nazir Ahmed; Jha, Swati; Clark, David; Lewis, James J.; Omar, Shaheed; Dreyer, Andries; Chihota, Violet; Churchyard, Gavin; Dowdy, David W. (Public Library of Science, 2016-06-20)
    BACKGROUND Automated digital microscopy has the potential to improve the diagnosis of tuberculosis (TB), particularly in settings where molecular testing is too expensive to perform routinely. The cost-effectiveness of ...
  • Pitout, Johann D.D.; Stoesser, Nicole; Sheppard, Anna E.; Peirano, Gisele; Sebra, Robert; Lynch, Tarah; Anson, Luke; Kasarskis, Andrew; Motyl, Mary R.; Crook, Derrick W. (American Society for Microbiology, 2016-05)
    The blaIMP-14 carbapenem resistance gene has largely previously been observed in Pseudomonas aeruginosa and Acinetobacter spp. As part of global surveillance and sequencing of carbapenem-resistant E. coli, we identified ...
  • Peters, Remco P.H.; Schaftenaar, E.; Baarsma, G.S.; Meenken, C.; Khosa, N.S.; Getu, S.; McIntyre, J.A.; Osterhaus, A.D.M.E.; Verjans, G.M.G.M. (SpringerOpen Journal, 2016-05)
    The purpose of this investigation was to determine the clinical and corneal microbial profile of infectious keratitis in a high human immunodeficiency virus (HIV) prevalence setting in rural South Africa. Data in this ...
  • Pitout, Johann D.D.; Lynch, T.; Chen, L.; Peirano, G.; Gregson, D.B.; Church, D.L.; Conly, J.; Kreiswirth, B.N. (Oxford University Press, 2016-06)
    During 2013, ST278 Klebsiella pneumoniae with blaNDM-7 was isolated from the urine (KpN01) and rectum (KpN02) of a patient in Calgary, Canada. The same strain (KpN04) was subsequently isolated from another patient in the ...
  • Redelinghuys, Mathys J.; Ehlers, M.M. (Marthie Magdaleen); Dreyer, Andries W.; Kock, Marleen M. (Taylor and Francis, 2016-05)
    The female genital tract is an intricate, yet balanced ecosystem that hosts a variety of different residential microflora. The physiological changes that occur during pregnancy may disrupt this balanced ecosystem and ...
  • Fourie, P.B. (Petrus Bernardus); Hennig, Stefanie; Svensson, Elin M.; Niebecker, Ronald; Weiner, Marc H.; Bonora, Stefano; Peloquin, Charles A.; Gallicano, Keith; Flexner, Charles; Pym, Alex; Vis, Peter; Olliaro, Piero L.; McIlleron, Helen; Karlsson, Mats O. (Oxford University Press, 2016-05)
    OBJECTIVES : Extensive but fragmented data from existing studies were used to describe the drug-drug interaction between rifabutin and HIV-protease inhibitors, and predict doses achieving recommended therapeutic exposure ...
  • Pitout, Johann D.D.; Church, Deirdre L.; Chan, Wilson (Taylor and Francis, 2016-07)
    Urinary tract infections (UTIs) are among the most common infectious diseases occurring in either the community or healthcare settings. A wide variety of bacteria are responsible for causing UTIs, however extra-intestinal ...
  • Ismail, Nazir Ahmed; Dreyer, Andries W.; Said, Halima M.; Kushner, Nicole; Omar, Shaheed V.; Koornhof, Hendrik; Erasmus, Linda; Gardee, Yasmin; Rukasha, Ivy; Shashkina, Elena; Beylis, Natalie; Kaplan, Gilla; Fallows, Dorothy (Public Library of Science, 2016-01-11)
    BACKGROUND In South Africa and other high prevalence countries, transmission is a significant contributor to rising rates of multidrug resistant tuberculosis (MDR-TB). Thus, there is a need to develop an early detection ...
  • Peters, Remco P.H.; Schaftenaar, E.; Meenken, C.; Baarsma, G.S.; McIntyre, J.A.; Verjans, G.M.G.M. (Wiley, 2016-03)
    OBJECTIVES : To describe the spectrum of ocular complications of herpes zoster ophthalmicus (HZO) in rural South Africa. METHODS : Patients presenting with visual complaints and active or healed HZO at the ophthalmology ...
  • Peters, Remco P.H.; Verweij, Stephan P.; McIntyre, J.A.; Schaftenaar, E. (Lippincott, Williams and Wilkins, 2016-02)
    We report a case of progressive, cephalosporin-susceptible, Neisseria gonorrhoeae conjunctivitis despite successful treatment of male urethritis syndrome. We hypothesize that conjunctival infection progressed due to ...
  • Ismail, Nazir Ahmed; Bradley, Phelim; Gordon, N. Claire; Walker, Timothy M.; Dunn, Laura; Heys, Simon; Huang, Bill; Earle, Sarah; Pankhurst, Louise J.; Anson, Luke; De Cesare, Mariateresa; Piazza, Paolo; Votintseva, Antonina A.; Golubchik, Tanya; Wilson, Daniel J.; Wyllie, David H.; Diel, Ronald; Niemann, Stefan; Feuerriegel, Silke; Kohl, Thomas A.; Omar, Shaheed V.; Smith, E. Grace; Buck, David; McVean, Gil; Walker, A. Sarah; Peto, Tim E.A.; Crook, Derrick W.; Iqbal, Zamin (Nature Publishing Group, 2015-12-21)
    The rise of antibiotic-resistant bacteria has led to an urgent need for rapid detection of drug resistance in clinical samples, and improvements in global surveillance. Here we show how de Bruijn graph representation of ...

View more