Comparison of three commercial molecular assays for detection of rifampin and isoniazid resistance among Mycobacterium tuberculosis isolates in a high-HIV-prevalence setting
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| dc.contributor.author | Strydom, Kathy-Anne
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| dc.contributor.author | Ismail, Farzana
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| dc.contributor.author | Matabane, M.M.Z.
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| dc.contributor.author | Onwuegbuna, O.
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| dc.contributor.author | Omar, Shaheed Vally
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| dc.contributor.author | Ismail, Nabila
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| dc.date.accessioned | 2015-12-04T05:18:33Z | |
| dc.date.issued | 2015-09 | |
| dc.description.abstract | In a head to head comparison of the MTBDRplus Version 2.0 (Hain Lifescience), Xpert® MTB/RIF (Cepheid) and the Anyplex™ MTB/NTM (Seegene) assays we demonstrate equal sensitivity (59/61; 96.7%) and specificity (53/54; 98.1%) for detecting rifampicin resistance with further analysis of discordances. The Xpert does not detect Isoniazid resistance while Anyplex showed high false positivity. | en_ZA |
| dc.description.embargo | 2016-03-31 | |
| dc.description.librarian | hb2015 | en_ZA |
| dc.description.sponsorship | National Health Laboratory Services | en_ZA |
| dc.description.uri | http://jcm.asm.org | en_ZA |
| dc.identifier.citation | Strydom, KA, Ismail, F, Matabane, MMZ, Onwuegbuna, O, Omar, SV & Ismail, N 2015, 'Comparison of three commercial molecular assays for detection of rifampin and isoniazid resistance among Mycobacterium tuberculosis isolates in a high-HIV-prevalence setting', Journal of Clinical Microbiology, vol. 53, no. 9, pp. 3032-3034. | en_ZA |
| dc.identifier.issn | 0095-1137 (print) | |
| dc.identifier.issn | 1098-660X (online) | |
| dc.identifier.other | 10.1128/JCM.01691-15 | |
| dc.identifier.uri | http://hdl.handle.net/2263/51054 | |
| dc.language.iso | en | en_ZA |
| dc.publisher | American Society for Microbiology | en_ZA |
| dc.rights | © 2015. American Society for Microbiology. All Rights Reserved. | en_ZA |
| dc.subject | Rifampicin | en_ZA |
| dc.subject | Isoniazid | en_ZA |
| dc.subject | Mycobacterium tuberculosis | en_ZA |
| dc.subject | High HIV prevalence setting | en_ZA |
| dc.title | Comparison of three commercial molecular assays for detection of rifampin and isoniazid resistance among Mycobacterium tuberculosis isolates in a high-HIV-prevalence setting | en_ZA |
| dc.type | Postprint Article | en_ZA |
