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Research Articles (Pharmacology): Recent submissions
Now showing items 1-20 of 275
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(MDPI, 2023-12)BACKGROUND : Information regarding off-label and unlicensed medicine use among South African children is limited. This is a concern as the prescribing of off-label and unlicensed medicines can lead to issues of effectiveness ...
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(Wiley, 2024-03)The physicochemical diversity of the structurally related aromatic probe drugs, used together in a drug cocktail to assess metabolic and transport phenotypes, require optimized analytical procedures for simultaneous ...
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(Medknow Publications, 2024-01)INTRODUCTION: There is considerable concern with rising rates of antimicrobial resistance (AMR) with its subsequent impact on morbidity, mortality and costs. In low- and middle-income countries, a key driver of AMR is the ...
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(BMC, 2024-02)The 5th edition of the Global Ministerial Summit on Patient Safety was held in Montreux, Switzerland, in February 2023, delayed by three years due to the COVID-19 pandemic. The overarching theme of the summit was “Less Harm, ...
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(Elsevier, 2023-06)ETHNOPHARMACOLOGICAL RELEVANCE : Tea (Camellia sinensis) has been consumed for centuries as traditional medicine for various diseases, including diabetes. The mechanism of action of many traditional medicines, including ...
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(Elsevier, 2023-10)ETHNOPHARMACOLOGICAL RELEVANCE : Herb-induced liver injury is poorly described for African herbal remedies, such as Acokanthera oppositifolia. Although a commonly used treatment for pain, snake bites and anthrax, it is ...
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(Elsevier, 2024-09)BACKGROUND : Hospitalized neonates are vulnerable to infection and have high rates of antibiotic utilization. METHODS : Fourteen South African neonatal units (seven public, seven private sector) assembled multidisciplinary ...
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(Medpharm Publications, 2023)Pharmacy council inspectors play a crucial role in ensuring the quality, safety, and compliance of pharmacies with established regulations and standards. These inspectors are typically appointed by pharmacy regulatory ...
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(Medpharm Publications, 2023)This article outlines the principles of blood pressure, including normal and dysfunctional physiology, mathematical equations of pressure, definitions of hypertension and diagnosis, and hence the rationale for and mechanisms ...
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(Medpharm Publications, 2023)For drugs with a narrow therapeutic index (NTI) like tacrolimus, small changes in dosage can lead to significant changes in blood levels, which can affect both the effectiveness of the drug and the risk of adverse effects. ...
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(Medpharm Publications, 2023)Pharyngitis and tonsilitis are common reasons why people seek medical care. These diseases are commonly caused by viral and bacterial infections, with group A β-haemolytic streptococcus being pharyngitis's most common ...
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(Association of Physicians of India, 2023-07)INTRODUCTION : Peripheral neuropathy (PN) is an insidious disease that is often asymptomatic during the early stages but which can have a significant impact on quality of life at later stages when nerve damage occurs. There ...
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(University of Toronto Press, 2024)Antimicrobial resistance (AMR) has become a major global public health crisis due to inappropriate use in humans, animals, and crops. Studies to assess the knowledge and perceptions of antimicrobial stewardship (AMS) ...
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(Elsevier, 2024-07)Please read abstract in the article.
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(Taylor and Francis, 2023)INTRODUCTION : Antimicrobial resistance (AMR) is a global concern. Currently, the greatest mortality due to AMR is in Africa. A key driver continues to be high levels of dispensing of antibiotics without a prescription. AREAS ...
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(BMC, 2023-06-19)BACKGROUND : In recent years, numerous dosing studies have been conducted to optimize therapeutic antibiotic exposures in patients with serious infections. These studies have led to the inclusion of dose optimization ...
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(Wiley, 2023-04)The special themed issue; ‘Highlights of Basic and Clinical Pharmacology from Africa’ is a compilation of contributions from both basic and clinical research from the African continent. The publications included in this ...
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(MDPI, 2023-07-05)Interethnic and interindividual variability in in vivo cytochrome P450 (CYP450)-dependent metabolism and altered drug absorption via expressed transport channels such as P-glycoprotein (P-gp) contribute to the adverse ...
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(BMC, 2023-06-01)OBJECTIVE : Retinoic acid (RA) is known to transition proliferating SH-SY5Y neuroblastoma cells towards functional neurons. However, the activity of RA is restricted due to its photolability where any findings from prolonged ...
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(MDPI, 2023-05-19)Three-dimensional cell culture models are increasingly adopted as preferred pre-clinical drug testing platforms, as they circumvent limitations associated with traditional monolayer cell cultures. However, many of these ...
Now showing items 1-20 of 275