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Browsing Research Articles (Medical Microbiology) by UP Author "Osei Sekyere, John"
Now showing items 1-20 of 25
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Somboro, Anou M.; Amoako, Daniel G.; Osei Sekyere, John; Kumalo, Hezekiel M.; Khan, René; Bester, Linda A.; Essack, Sabiha Y. (American Society for Microbiology, 2019-02)Metallo-β-lactamase (MBL)-producing Enterobacteriaceae are of grave clinical concern, particularly as there are no metallo-β-lactamase inhibitors approved for clinical use. The discovery and development of MBL inhibitors ...
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Osei Sekyere, John; Reta, Melese Abate; Maningi, Nontuthuko Excellent; Fourie, P.B. (Petrus Bernardus) (Elsevier, 2019-12)BACKGROUND : Tuberculosis (TB) remains a main global public health problem. However, a systematic review of TB resistance epidemiology in Africa is wanting. METHODS : A comprehensive systematic search of PubMed, Web of ...
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Osei Sekyere, John; Sephofane, Arnold Karabo; Mbelle, Nontombi Marylucy (Nature Publishing Group, 2020-04-10)Colistin has become a critical antibiotic for fatal Gram-negative infections owing to the proliferation of multidrug-resistant carbapenemase-producing bacteria. Thus, cheaper, faster, efficient and easier-touse colistin ...
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Osei Sekyere, John; Maphalala, Nontobeko; Malinga, Lesibana Anthony; Mbelle, Nontombi Marylucy; Maningi, Nontuthuko Excellent (Nature Publising Group, 2019-11)Studies evaluating the new GeneXpert Ultra with other rapid diagnostic assays are limited, particularly in diferent geographical settings. The performance of the GeneXpert Ultra, the GeneXpert G4, the Line probe assays ...
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Somboro, Anou M.; Osei Sekyere, John; Amoako, Daniel G.; Essack, Sabiha Y.; Bester, Linda A. (American Society for Microbiology, 2018-09)The worldwide proliferation of life-threatening metallo-β-lactamase (MBLs)-producing Gram-negative bacteria is a serious concern to public health. MBLs are compromising the therapeutic efficacies of β-lactams, particularly ...
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Osei Sekyere, John; Maningi, Nontuthuko Excellent; Modipane, Lesedi; Mbelle, Nontombi Marylucy (American Society for Microbiology, 2020-05)Extended-spectrum-β-lactamase (ESBL)-producing Enterobacteriaceae are critical-priority pathogens that cause substantial fatalities. With the emergence of mobile mcr genes mediating resistance to colistin in Enterobacteriaceae, ...
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Mmatli, Masego; Mbelle, Nontombi Marylucy; Maningi, Nontuthuko Excellent; Osei Sekyere, John (American Society for Microbiology, 2020-11)The spread of carbapenem- and polymyxin-resistant Enterobacteriaceae poses a significant threat to public health, challenging clinicians worldwide with limited therapeutic options. This review describes the current coding ...
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Kopotsa, Katlego; Mbelle, Nontombi Marylucy; Osei Sekyere, John (Microbiology Society, 2020-11-10)Carbapenem-resistant Klebsiella pneumoniae (CRKP) remains a major clinical pathogen and public health threat with few therapeutic options. The mobilome, resistome, methylome, virulome and phylogeography of CRKP in South ...
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Rule, Roxanne; Said, Mohamed; Mbelle, Nontombi Marylucy; Osei Sekyere, John (Elsevier, 2019-12)OBJECTIVES : The underlying resistance mechanism and phylogenetic relationship of a colistin-resistant Salmonella enterica serovar Enteritidis strain EC20120916 that resulted in fatal meningitis in an immunocompromised ...
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Mbelle, Nontombi Marylucy; Osei Sekyere, John; Amoako, Daniel Gyamfi; Maningi, Nontuthuko Excellent; Modipane, Lesedi; Essack, Sabiha Yusuf; Feldman, Charles (Wiley, 2020-02)Please read abstract in the article.
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Mbelle, Nontombi Marylucy; Osei Sekyere, John; Feldman, Charles; Maningi, Nontuthuko Excellent; Modipane, Lesedi; Essack, Sabiha Y. (Wiley, 2020-01)Morganella morganii is an opportunistic bacterial pathogen of the Enterobacteriaceae family that is occasionally isolated from clinical (animal and human) specimens with varying resistance profiles. Detailed genomic analyses ...
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Osei Sekyere, John; Reta, Melese Abate (American Society for Microbiology, 2020-11-24)Antibiotic resistance (AR) remains a major threat to public and animal health globally. However, AR ramifications in developing countries are worsened by limited molecular diagnostics, expensive therapeutics, inadequate ...
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Osei Sekyere, John; Reta, Melese Abate (Wiley, 2021-12)Citrobacter spp., Enterobacter hormaechei subsp., Klebsiella variicola and Proteae tribe members are rarely isolated Enterobacterales increasingly implicated in nosocomial infections. Herein, we show that these species ...
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Somboro, A.M.; Osei Sekyere, John; Amoako, Daniel G.; Kumalo, Hezekiel M.; Khan, R.; Bester, L.A.; Essack, S.Y. (Wiley, 2019-02)AIMS : We hypothesized and confirmed that tannic acid (TA) reverses carbapenem resistance by inhibiting carbapenemases in class A and B carbapenemase‐producing Enterobacteriaceae. METHODS AND RESULTS: Minimum inhibitory ...
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Osei Sekyere, John (Wiley, 2019-04)Resistance to colistin, mediated by chromosomal mutations and more recently, by plasmid-borne mcr genes, is increasingly being reported in bacterial isolates taken from humans, animals, farms, foods, and the environment. ...
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Osei Sekyere, John; Mensah, Eric (Wiley, 2020-04)Health perspective is lacking. Here, we report result from a search for English‐language articles on the resistance mechanisms and clonality of Gram‐positive bacteria in Africa between 2007 and 2019 reported in PubMed, Web ...
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Maningi, Nontuthuko Excellent; Daum, Luke T.; Rodriguez, John D.; Said, Halima M.; Peters, Remco P.H.; Osei Sekyere, John; Fischer, Gerald W.; Chambers, James P.; Fourie, P.B. (Petrus Bernardus) (American Society for Microbiology, 2018-05)Modern advances in genomics provide an opportunity to reinterpret historical bacterial culture collections. In this study, genotypic antibiotic resistance profiles of Mycobacterium tuberculosis isolates from a historical ...
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Osei Sekyere, John; Maningi, Nontuthuko Excellent; Fourie, P.B. (Petrus Bernardus) (Wiley, 2020-05)Increasingly, gut microbiota distortions are being implicated in the pathogenesis of several infectious and noninfectious diseases. Specifically, in the absence of an eubiotic microbiota, mice are more prone to colonization ...
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Mbelle, Nontombi Marylucy; Feldman, Charles; Osei Sekyere, John; Maningi, Nontuthuko Excellent; Modipane, Lesedi; Essack, Sabiha Yusuf (Nature Publishing Group, 2020)Antibiotic-resistant Klebsiella pneumoniae is increasingly being implicated in invasive infections worldwide with high mortalities. Forty-two multidrug resistant (MDR) K. pneumoniae isolates were collected over a 4-month ...
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Modipane, Lesedi; Reva, Oleg N.; Magazi, Beki T.; Antiabong, John Francis; Osei Sekyere, John; Mbelle, Nontombi Marylucy (Elsevier, 2019-10)BACKGROUND : Mycobacterium bovis BCG is a live, attenuated tuberculosis vaccine. While the vaccine protects infants from tuberculosis, complications including disseminated infections have been reported following ...
Now showing items 1-20 of 25