Browsing Research Articles (Biochemistry) by UP Author "Joubert, Fourie"

Browsing Research Articles (Biochemistry) by UP Author "Joubert, Fourie"

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  • Characterization of carbonic anhydrase isozyme specific inhibition by sulfamated 2-ethylestra compounds 
    Sippel, Katherine H.; Stander, Andre; Tu, Chingkuang; Venkatakrishnan, Balasubramanian; Robbins, Arthur H.; Agbandje-McKenna, Mavis; Joubert, Fourie; Joubert, Annie M.; McKenna, Robert (Bentham Science, 2011-10)
    Sulfamated 2-ethylestra compounds have demonstrated strong anticancer activity, high bioavailability and an ability to bypass liver metabolism by reversibly binding carbonic anhydrase (CA) II in erythrocytes. Another CA ...
  • Developing reproducible bioinformatics analysis workflows for heterogeneous computing environments to support African genomics 
    Baichoo, Shakuntala; Souilmi, Yassine; Panji, Sumir; Botha, Gerrit; Meintjes, Ayton; Hazelhurst, Scott; Bendou, Hocine; De Beste, Eugene; Mpangase, Phelelani T.; Souiai, Oussema; Alghali, Mustafa; Yi, Long; O’Connor, Brian D.; Crusoe, Michael; Armstrong, Don; Aron, Shaun; Joubert, Fourie; Ahmed, Azza E.; Mbiyavanga, Mamana; Van Heusden, Peter; Magosi, Lerato E.; Zermeno, Jennie; Mainzer, Liudmila Sergeevna; Fadlelmola, Faisal M.; Jongeneel, C. Victor; Mulder, Nicola (BioMed Central, 2018-11-29)
    BACKGROUND : The Pan-African bioinformatics network, H3ABioNet, comprises 27 research institutions in 17 African countries. H3ABioNet is part of the Human Health and Heredity in Africa program (H3Africa), an African-led ...
  • The development of computational biology in South Africa : successes achieved and lessons learnt 
    Mulder, Nicola J.; Christoffels, Alan; De Oliveira, Tulio; Gamieldien, Junaid; Hazelhurst, Scott; Joubert, Fourie; Kumuthini, Judit; Pillay, Che S.; Snoep, Jacky L.; Bishop, Ozlem Tastan; Tiffin, Nicki (Public Library of Science, 2016-02-04)
    Bioinformatics is now a critical skill in many research and commercial environments as biological data are increasing in both size and complexity. South African researchers recognized this need in the mid-1990s and ...
  • Discovery : an interactive resource for the rational selection and comparison of putative drug target proteins in malaria 
    Joubert, Fourie; Harrison, Claudia M.; Koegelenberg, Riaan J.; Odendaal, Christiaan J.; De Beer, T.A.P. (Tjaart Andries Petrus) (BioMed Central, 2009-07)
    BACKGROUND: Up to half a billion human clinical cases of malaria are reported each year, resulting in about 2.7 million deaths, most of which occur in sub-Saharan Africa. Due to the over-and misuse of anti-malarials, ...
  • Discovery-2 : an interactive resource for the rational selection and comparison of putative drug target proteins in malaria 
    Mpangase, Phelelani Thokozani; Szolkiewicz, Michal Jerzy; Le Grange, Misha; Smit, Jeanre H.; Burger, Pieter Buys; Joubert, Fourie (BioMed Central, 2013-03-28)
    BACKGROUND: Drug resistance to anti-malarial compounds remains a serious problem, with resistance to newer pharmaceuticals developing at an alarming rate. The development of new anti-malarials remains a priority, and ...
  • Draft genome of Cercospora zeina, Fusarium pininemorale, Hawksworthiomyces lignivorus, Huntiella decipiens and Ophiostoma ips 
    Wingfield, Brenda D.; Berger, David Kenneth; Steenkamp, Emma Theodora; Lim, Hye-Jin; Duong, Tuan A.; Bluhm, Burton H.; De Beer, Z. Wilhelm; De Vos, Lieschen; Fourie, Gerda; Naidoo, Kershney; Olivier, Nicholas Abraham; Lin, Yao-Cheng; Van de Peer, Yves; Joubert, Fourie; Crampton, Bridget Genevieve; Swart, Velushka; Soal, Nicole Christine; Tatham, Catherine; Van der Nest, Magrieta Aletta; Van der Merwe, Nicolaas Albertus (Albie); Van Wyk, Stephanie; Wilken, Pieter Markus; Wingfield, Michael J. (International Mycological Association, 2017-11-21)
    The genomes of Cercospora zeina, Fusarium pininemorale, Hawksworthiomyces lignivorus, Huntiella decipiens, and Ophiostoma ips are presented in this genome announcement. Three of these genomes are from plant pathogens and ...
  • The draft genome of Deladenus siricidicola 
    Postma, Alisa; Mlonyeni, X.O.M. (Xolile Osmond Mnyamezeli); Clasen, Frederick Johannes; Joubert, Fourie; Slippers, Bernard (Exeley, 2019)
    The nematode Deladenus siricidicola is used as biological control agent against the invasive woodwasp Sirex noctilio, a serious invasive pest of Pinus plantations globally. The draft genome of this ecologically ...
  • Functional annotation of putative QTL associated with black tea quality and drought tolerance traits 
    Koech, Robert K.; Malebe, Pelly Masixolise; Nyarukowa, Christopher; Mose, Richard; Kamunya, Samson M.; Joubert, Fourie; Apostolides, Zeno (Nature Research, 2019-02)
    The understanding of black tea quality and percent relative water content (%RWC) traits in tea (Camellia sinensis) by a quantitative trait loci (QTL) approach can be useful in elucidation and identification of candidate ...
  • H3ABioNet, a sustainable pan-African bioinformatics network for human heredity and health in Africa 
    Mulder, Nicola J.; Adebiyi, Ezekiel; Alami, Raouf; Benkahla, Alia; Brandful, James; Doumbia, Seydou; Everett, Dean; Fadlelmola, Faisal M.; Gaboun, Fatima; Gaseitsiwe, Simani; Ghazal, Hassan; Hazelhurst, Scott; Hide, Winston; Ibrahimi, Azeddine; Fakim, Yasmina Jaufeerally; Jongeneel, C. Victor; Joubert, Fourie; Kassim, Samar; Kayondo, Jonathan; Kumuthini, Judit; Lyantagaye, Sylvester; Makani, Julie; Alzohairy, Ahmed Mansour; Masiga, Daniel; Moussa, Ahmed; Nash, Oyekanmi; Oukem-Boyer, Odile Ouwe Missi; Owusu-Dabo, Ellis; Panji, Sumir; Patterton, Hugh; Radouani, Fouzia; Sadki, Khalid; Seghrouchni, Fouad; Bishop, Ozlem Tastan; Tiffin, Nicki; Ulenga, Nzovu; The H3ABioNet Consortium (Cold Spring Harbor Laboratory Press, 2016-12-01)
    The application of genomics technologies to medicine and biomedical research is increasing in popularity, made possible by new high-throughput genotyping and sequencing technologies and improved data analysis capabilities. ...
  • Influence of Sutherlandia frutescens extracts on cell numbers, morphology and gene expression in MCF-7 cells 
    Stander, Barend Andre; Marais, Sumari; Steynberg, Tenille Jolene; Theron, D.; Joubert, Fourie; Albrecht, C.; Joubert, Annie M. (Elsevier, 2007-06-13)
    Sutherlandia frutescens is a well-known South African herbal remedy traditionally used for stomach problems, internal cancers, diabetes, various inflammatory conditions and recently to improve the overall health in cancer ...
  • Integration and mining of malaria molecular, functional and pharmacological data : how far are we from a chemogenomic knowledge space? 
    Birkholtz, Lyn-Marie; Bastien, Olivier; Wells, Gordon; Grando, Delphine; Joubert, Fourie; Kasam, Vinod; Zimmermann, Marc; Ortet, Philippe; Jacq, Nicolas; Saidani, Nadia; Roy, Sylvaine; Hofmann-Apitius, Martin; Breton, Vincent; Louw, Abraham Izak; Marechal, Eric (BioMed Central, 2006-11)
    The organization and mining of malaria genomic and post-genomic data is important to significantly increase the knowledge of the biology of its causative agents, and is motivated, on a longer term, by the necessity to ...
  • MADIBA : A web server toolkit for biological interpretation of Plasmodium and plant gene clusters 
    Law, Philip J.; Claudel-Renard, Clotilde; Joubert, Fourie; Louw, Abraham Izak; Berger, David Kenneth (BioMed Central, 2008)
    BACKGROUND: Microarray technology makes it possible to identify changes in gene expression of an organism, under various conditions. Data mining is thus essential for deducing significant biological information such as the ...
  • A novel inhibitor of plasmodium falciparum spermidine synthase : a twist in the tail 
    Burger, Pieter Buys; Williams, Marni; Sprenger, Janina; Reeksting, S.B. (Shaun Bernard); Botha, M.E. (Mariette); Muller, Ingrid B.; Joubert, Fourie; Birkholtz, Lyn-Marie; Louw, Abraham Izak (BioMed Central, 2015-02-05)
    BACKGROUND : Plasmodium falciparum is the most pathogenic of the human malaria parasite species and a major cause of death in Africa. It’s resistance to most of the current drugs accentuates the pressing need for ...
  • Protein homology modelling and its use in South Africa 
    Bishop, A. Ozlem Tastan; De Beer, T.A.P. (Tjaart Andries Petrus); Joubert, Fourie (Academy of Science of South Africa, 2008)
    No abstract available
  • Structural and mechanistic insights into the action of Plasmodium falciparum spermidine synthase 
    Burger, Pieter Buys; Birkholtz, Lyn-Marie; Joubert, Fourie; Haider, Nashya; Walter, Rolf D.; Louw, Abraham Izak (Elsevier, 2007-02)
    Spermidine synthase is currently considered as a promising drug target in the malaria parasite, Plasmodium falciparum, due to the vital role of spermidine in the activation of the eukaryotic translation initiation factor ...
  • A structural annotation resource for the selection of putative target proteins in the malaria parasite 
    Joubert, Yolandi; Joubert, Fourie (BioMed Central, 2008)
    BACKGROUND: Protein structure plays a pivotal role in elucidating mechanisms of parasite functioning and drug resistance. Moreover, protein structure aids the determination of protein function, which can together with the ...
  • Whole-genome sequencing for an enhanced understanding of genetic variation among South Africans 
    Choudhury, Ananyo; Ramsay, Michele; Hazelhurst, Scott; Aron, Shaun; Bardien, Soraya; Botha, Gerrit; Chimusa, Emile R.; Christoffels, Alan; Gamieldien, Junaid; Sefid-Dashti, Mahjoubeh J.; Joubert, Fourie; Meintjes, Ayton; Mulder, Nicola; Ramesar, Raj; Rees, Jasper; Scholtz, Kathrine; Sengupta, Dhriti; Soodyall, Himla; Venter, Philip; Warnich, Louise; Pepper, Michael Sean (Nature Publishing Group, 2017-12-12)
    The Southern African Human Genome Programme is a national initiative that aspires to unlock the unique genetic character of southern African populations for a better understanding of human genetic diversity. In this pilot ...