Research Articles (Biochemistry)

Research Articles (Biochemistry)

 

This collection contains some of the full text peer-reviewed/ refereed articles published by researchers from the Department of Biochemistry

For inquiries regarding this collection or items in the collection, please contact
Janice de Wee Tel.: +27 12 420 2940

Recent Submissions

  • Motshwene, Precious G.; Dossang, Anthony C.G.; Yang, Yang; Symmons, Martyn F.; Bryant, Clare E.; Borman, Satty; George, Julie; Weber, Alexander N.R.; Gay, Nicholas J. (Nature Publishing Group, 2016-11-23)
    Activation of Toll-like receptors induces dimerization and the recruitment of the death domain (DD) adaptor protein MyD88 into an oligomeric post receptor complex termed the Myddosome. The Myddosome is a hub for inflammatory ...
  • Meyer, Debra; Masebe, Tracy Madimabi; Bessong, Pascal Obong; Nwobegahay, Julius; Ndip, Roland Ndip (IOS Press, 2012)
    Data on genetic polymorphisms associated with response to anti-HIVdrugs has accumulated over the years. Information on how polymorphisms influence drug metabolism and transport to target sites is important in guiding ...
  • Beukes, Mervyn; Mampholo, Bevly Mmakatane; Sivakumar, Dharini; Van Rensburg, Willem J. (Wiley, 2013-06)
    BACKGROUND : The perishability of Brassica chinensis poses a major challenge to distribution and marketing. The aim of this work was to select a suitable modified atmosphere packaging to retain the overall quality and ...
  • Apostolides, Zeno; Shoko, T.; Monjerezi, M.; Saka, J.D.K. (Elsevier, 2013-01)
    Volatile constituents of the edible pulp of Strychnos cocculoides (Monkey orange) were extracted using solid phase microextraction (SPME) and their identity established by GC–FID and GC–MS systems. Six compounds were ...
  • Reva, Oleg; Borriss, Rainer; Rueckert, Christian; Blom, Jochen; Bezuidt, Oliver (Elsevier, 2011)
    This chapter is devoted to application of whole genome sequence comparisons in taxonomy. Driven by the rapid progress in sequencing technologies, “low budget” bacterial genomes become increasingly available in a nearly ...
  • Rossouw, C.L. (Claire Louise); Birkholtz, Lyn-Marie; Hoppe, Heinrich C.; Chetty, Avashnee; Moolman, F. Sean; Mancama, Dalu T. (Wiley, 2012-08)
    The thermo-responsive polymer poly(N-isopropylacrylamide) has received widespread attention for its in vitro application in the non-invasive, non-destructive release of adherent cells on two dimensional surfaces. In this ...
  • Mancama, Dalu; Birkholtz, Lyn-Marie; Coetzer, Theresa L.; Leroy, Didier; Alano, Pietro (Elsevier, 2016-09)
    The ability to target human-mosquito parasite transmission challenges global malaria elimination. However, it is not obvious what a transmission-blocking drug will look like; should it 1) target only parasite transmission ...
  • Verschoor, J.A. (Jan Adrianus); Smet, Muriel; Pollard, Charlotte; De Beuckelaer, Ans; Van Hoecke, Lien; Vander Beken, Seppe; De Koker, Stefaan; Al Dulayymi, Juma’a R.; Huygen, Kris; Baird, Mark S.; Grooten, Johan (Wiley, 2016-09)
    Mycolic acids (MAs) are highly hydrophobic long-chain α-alkyl β-hydroxy fatty acids present in the cell wall of Mycobacterium tuberculosis (Mtb) as a complex mixture of molecules with a common general structure but with ...
  • Pereira, Andreia S.P.; Bester, Megan J.; Apostolides, Zeno; Soundy, Puffy (Taylor and Francis, 2016-09)
    CONTEXT : Pelargonium sidoides DC (Geraniaceae) is an important medicinal plant indigenous to South Africa and Lesotho. Previous studies have shown root extracts rich in polyphenolic compounds with antibacterial, antiviral ...
  • Verlinden, Bianca K.; Louw, Abraham Izak; Birkholtz, Lyn-Marie (Taylor and Francis, 2016-02)
    INTRODUCTION : Currently, widely used antimalarial drugs have a limited clinical lifespan due to parasite resistance development. With resistance continuously rising, antimalarial drug discovery requires strategies to ...
  • Reva, Oleg N.; Kharina, A.; Faidyuk, Yu; Zaika, S.; Haidak, A.; Kukharenko, O.; Podolich, O.; Zaets, I.; Tovkach, F.; Kozyrovska, N. (Wiley, 2015-04)
    The acetic acid bacteria have mainly relevance for bacterial cellulose production and fermented bio-products manufacture. The purpose of this study was to identify temperate bacteriophages in a cellulose-producing bacterial ...
  • Coertzen, Dina; Birkholtz, Lyn-Marie; Beteck, Richard M.; Smit, Frans J.; Haynes, Richard K.; N’Da, David D. (Elsevier, 2016-07)
    As part of a programme aimed at identifying rational new triple drug combinations for treatment of malaria, tuberculosis and toxoplasmosis, we have selected quinolones as one component, given that selected examples exhibit ...
  • Gama, Ntombenhle; Meyer, Debra; Kumar, Kamlesh; Ekengard, Erik; Haukka, Matti; Darkwa, James; Nordlander, Ebbe (Springer, 2016-06)
    HIV infection is known for replication in proliferating CD+ T-cells. Treatment of these cells with cytostatic (anti-proliferation) compounds such as hydroxyurea interferes with the cells’s ability support HIV replication. ...
  • Reva, Oleg N.; Alcaide, María; Stogios', Peter J.; Lafraya, Álvaro; Tchigvintsev, Anatoli; Flick, Robert; Bargiela, Rafael; Chernikova, Tatyana N.; Hai, Tran; Leggewie, Christian C.; Katzke, Nadine; La Cono, Violetta; Matesanz, Ruth; Jebbar, Mohamed; Jaeger, Karl-Erich; Yakimov, Michail M.; Yakunin, Alexander F.; Golyshin, Peter N.; Golyshina, Olga V.; Savchenko, Alexei; Ferrer, Manuel; The MAMBA Consortium (Wiley, 2015-02)
    The present study provides a deeper view of protein functionality as a function of temperature, salt and pressure in deep-sea habitats. A set of eight different enzymes from five distinct deep-sea (3040–4908 m depth), ...
  • Reva, Oleg N.; Zaets, I.YE.; Podolich, O.V.; Kozyrovska, N.O. (Institute of molecular biology and genetics, National Academy of Sciences of Ukraine, 2016)
    High-throughput sequencing allows obtaining DNA barcodes of multiple species of microorganisms from a single environmental sample. Next Generation Sequencing (NGS)-based profiling provides new opportunities to evaluate ...
  • Joubert, Fourie; Mulder, Nicola J.; Christoffels, Alan; De Oliveira, Tulio; Gamieldien, Junaid; Hazelhurst, Scott; Kumuthini, Judit; Pillay, Che S.; Snoep, Jacky L.; Bishop, Ozlem Tastan; Tiffin, Nicki (Public Library of Science, 2016-02-04)
    Bioinformatics is now a critical skill in many research and commercial environments as biological data are increasing in both size and complexity. South African researchers recognized this need in the mid-1990s and ...
  • Schubert, Wolf-Dieter; Cloete, Ruben; Oppon, Ekow; Murungi, Edwin; Christoffels, Alan (BioMed Central, 2016-02-08)
    BACKGROUND : Increasing resistance to anti-tuberculosis drugs has driven the need for developing new drugs. Resources such as the tropical disease research (TDR) target database and AssessDrugTarget can help to ...
  • Van der Westhuizen, Magdalien; Apostolides, Zeno; Steenkamp, Lucia; Steenkamp, Paul (Taylor & Francis, 2016-03)
    The principal pigments present in black tea, theaflavins (TF), have been indicated to be of potential clinical significance in various fields of research which has been hampered by the very low levels of TFs from black tea ...
  • Rabie, E.; Serem, June Cheptoo; Oberholzer, Hester Magdalena; Gaspar, A.R.M. (Anabella Regina Marques); Bester, Megan J. (Taylor and Francis, 2016-03)
    Antibacterial activity of honey is due to the presence of methylglyoxal (MGO), H2O2, bee defensin as well as polyphenols. High MGO levels in manuka honey are the main source of antibacterial activity. Manuka honey has ...
  • Kapewangolo, Petrina T.; Bruwer, Ronel; Fonteh, Pascaline Nanga; Meyer, Debra; Omolo, Justin J. (BioMed Central, 2015-12)
    BACKGROUND : Plants from the genus Ocimum are used as folk medicine for treating various diseases including inflammatory and immune-related diseases. Numerous reports have suggested plant extracts and their constituents as ...

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