Research Articles (Biochemistry)

Research Articles (Biochemistry)

 

This collection contains some of the full text peer-reviewed/ refereed articles published by researchers from the Department of Biochemistry

For inquiries regarding this collection or items in the collection, please contact
Janice de Wee Tel.: +27 12 420 2940

Recent Submissions

  • Joubert, Fourie; Mulder, Nicola J.; Adebiyi, Ezekiel; Alami, Raouf; Benkahla, Alia; Brandful, James; Doumbia, Seydou; Everett, Dean; Fadlelmola, Faisal M.; Gaboun, Fatima; Gaseitsiwe, Simani; Ghazal, Hassan; Hazelhurst, Scott; Hide, Winston; Ibrahimi, Azeddine; Fakim, Yasmina Jaufeerally; Jongeneel, C. Victor; Kassim, Samar; Kayondo, Jonathan; Kumuthini, Judit; Lyantagaye, Sylvester; Makani, Julie; Alzohairy, Ahmed Mansour; Masiga, Daniel; Moussa, Ahmed; Nash, Oyekanmi; Oukem-Boyer, Odile Ouwe Missi; Owusu-Dabo, Ellis; Panji, Sumir; Patterton, Hugh; Radouani, Fouzia; Sadki, Khalid; Seghrouchni, Fouad; Bishop, Özlem Tastan; Tiffin, Nicki; Ulenga, Nzovu; The H3ABioNet Consortium (Cold Spring Harbor Laboratory Press, 2016-12-01)
    The application of genomics technologies to medicine and biomedical research is increasing in popularity, made possible by new high-throughput genotyping and sequencing technologies and improved data analysis capabilities. ...
  • Schubert, Wolf-Dieter; Fang, Zhuo; Van Pittius, Nicolaas Claudius Gey (Elsevier, 2016-02-06)
    Mycobacteria encode five type VII secretion system (T7SS) or ESX for nutrient acquisition and virulence. Mycosins are membrane-anchored components of ESX with serine protease activity but an unidentified substrate range. ...
  • Reva, Oleg N.; Kublanov, IIya V.; Sigalova, Olga M.; Gavrilov, Sergey N.; Lebedinsky, Alexander V.; Rinke, Christian; Kovaleva, Olga; Chernyh, Nikolai A.; Ivanova, Natalia; Daum, Chris; Reddy, T.B.K.; Klenk, Hans-Peter; Spring, Stefan; Goker, Markus; Miroshnichenko, Margarita L.; Kyrpides, Nikos C.; Woyke, Tanja; Gelfand, Mikhall S.; Bonch-Osmolovskaya, Elizaveta A. (Frontiers Research Foundation, 2017-02-20)
    The genome of Caldithrix abyssi, the first cultivated representative of a phylum-level bacterial lineage, was sequenced within the framework of Genomic Encyclopedia of Bacteria and Archaea (GEBA) project. The genomic ...
  • Motshwene, Precious G.; Dossang, Anthony C.G.; Yang, Yang; Symmons, Martyn F.; Bryant, Clare E.; Borman, Satty; George, Julie; Weber, Alexander N.R.; Gay, Nicholas J. (Nature Publishing Group, 2016-11-23)
    Activation of Toll-like receptors induces dimerization and the recruitment of the death domain (DD) adaptor protein MyD88 into an oligomeric post receptor complex termed the Myddosome. The Myddosome is a hub for inflammatory ...
  • Meyer, Debra; Masebe, Tracy Madimabi; Bessong, Pascal Obong; Nwobegahay, Julius; Ndip, Roland Ndip (IOS Press, 2012)
    Data on genetic polymorphisms associated with response to anti-HIVdrugs has accumulated over the years. Information on how polymorphisms influence drug metabolism and transport to target sites is important in guiding ...
  • Beukes, Mervyn; Mampholo, Bevly Mmakatane; Sivakumar, Dharini; Van Rensburg, Willem J. (Wiley, 2013-06)
    BACKGROUND : The perishability of Brassica chinensis poses a major challenge to distribution and marketing. The aim of this work was to select a suitable modified atmosphere packaging to retain the overall quality and ...
  • Apostolides, Zeno; Shoko, T.; Monjerezi, M.; Saka, J.D.K. (Elsevier, 2013-01)
    Volatile constituents of the edible pulp of Strychnos cocculoides (Monkey orange) were extracted using solid phase microextraction (SPME) and their identity established by GC–FID and GC–MS systems. Six compounds were ...
  • Reva, Oleg N.; Borriss, Rainer; Rueckert, Christian; Blom, Jochen; Bezuidt, Oliver (Elsevier, 2011)
    This chapter is devoted to application of whole genome sequence comparisons in taxonomy. Driven by the rapid progress in sequencing technologies, “low budget” bacterial genomes become increasingly available in a nearly ...
  • Rossouw, C.L. (Claire Louise); Birkholtz, Lyn-Marie; Hoppe, Heinrich C.; Chetty, Avashnee; Moolman, F. Sean; Mancama, Dalu T. (Wiley, 2012-08)
    The thermo-responsive polymer poly(N-isopropylacrylamide) has received widespread attention for its in vitro application in the non-invasive, non-destructive release of adherent cells on two dimensional surfaces. In this ...
  • Mancama, Dalu; Birkholtz, Lyn-Marie; Coetzer, Theresa L.; Leroy, Didier; Alano, Pietro (Elsevier, 2016-09)
    The ability to target human-mosquito parasite transmission challenges global malaria elimination. However, it is not obvious what a transmission-blocking drug will look like; should it 1) target only parasite transmission ...
  • Verschoor, J.A. (Jan Adrianus); Smet, Muriel; Pollard, Charlotte; De Beuckelaer, Ans; Van Hoecke, Lien; Vander Beken, Seppe; De Koker, Stefaan; Al Dulayymi, Juma’a R.; Huygen, Kris; Baird, Mark S.; Grooten, Johan (Wiley, 2016-09)
    Mycolic acids (MAs) are highly hydrophobic long-chain α-alkyl β-hydroxy fatty acids present in the cell wall of Mycobacterium tuberculosis (Mtb) as a complex mixture of molecules with a common general structure but with ...
  • Mwita, Liberata; Chan, Wai Yin; Pretorius, Theresa; Reva, Oleg N.; Lyantagaye, Sylvester L.; Lapa, Svitlana V.; Avdeeva, Lilia V. (Elsevier, 2016-09)
    Despite successful use of Plant Growth Promoting Rhizobacteria (PGPR) in agriculture, little is known about specific mechanisms of gene regulation facilitating the effective communication between bacteria and plants ...
  • Pereira, Andreia S.P.; Bester, Megan J.; Apostolides, Zeno; Soundy, Puffy (Taylor and Francis, 2016-09)
    CONTEXT : Pelargonium sidoides DC (Geraniaceae) is an important medicinal plant indigenous to South Africa and Lesotho. Previous studies have shown root extracts rich in polyphenolic compounds with antibacterial, antiviral ...
  • Bezuidt, K.I.O. (Keoagile Ignatius Oliver); Pierneef, Rian; Van Goethem, Marc W.; Cowan, Don A.; Makhalanyane, Thulani P.; Gomri, Mohamed A.; Kharroub, Karima (Genomic Standards Consortium, 2016-09-09)
    The members of the genus Thermoactinomyces are known for their protein degradative capacities. Thermoactinomyces sp. strain AS95 is a Gram-positive filamentous bacterium, isolated from moderately saline water in the ...
  • Franzini, Philippa Z.N.; Ramond, Jean-Baptiste; Scholtz, Clarke H.; Sole, Catherine L.; Ronca, Sandra; Cowan, Don A. (Public Library of Science, 2016-08-17)
    Micro-organisms inhabiting animal guts benefit from a protected and nutrient-rich environment while assisting the host with digestion and nutrition. In this study we compare, for the first time, the bacterial and fungal ...
  • Verlinden, Bianca K.; Louw, Abraham Izak; Birkholtz, Lyn-Marie (Taylor and Francis, 2016-02)
    INTRODUCTION : Currently, widely used antimalarial drugs have a limited clinical lifespan due to parasite resistance development. With resistance continuously rising, antimalarial drug discovery requires strategies to ...
  • Reva, Oleg N.; Kharina, A.; Faidyuk, Yu; Zaika, S.; Haidak, A.; Kukharenko, O.; Podolich, O.; Zaets, I.; Tovkach, F.; Kozyrovska, N. (Wiley, 2015-04)
    The acetic acid bacteria have mainly relevance for bacterial cellulose production and fermented bio-products manufacture. The purpose of this study was to identify temperate bacteriophages in a cellulose-producing bacterial ...
  • Bezuidt, K.I.O. (Keoagile Ignatius Oliver); Pierneef, Rian; Adesioye, Fiyinfoluwa A.; Makhalanyane, Thulani P.; Cowan, Don A.; Gomri, Amin M.; Kharroub, Karima (Frontiers Research Foundation, 2016-05-24)
    The genus Geobacillus is comprised of a diverse group of spore-forming Gram-positive thermophilic bacterial species and is well known for both its ecological diversity and as a source of novel thermostable enzymes. ...
  • Coertzen, Dina; Birkholtz, Lyn-Marie; Beteck, Richard M.; Smit, Frans J.; Haynes, Richard K.; N’Da, David D. (Elsevier, 2016-07)
    As part of a programme aimed at identifying rational new triple drug combinations for treatment of malaria, tuberculosis and toxoplasmosis, we have selected quinolones as one component, given that selected examples exhibit ...
  • Gama, Ntombenhle; Meyer, Debra; Kumar, Kamlesh; Ekengard, Erik; Haukka, Matti; Darkwa, James; Nordlander, Ebbe (Springer, 2016-06)
    HIV infection is known for replication in proliferating CD+ T-cells. Treatment of these cells with cytostatic (anti-proliferation) compounds such as hydroxyurea interferes with the cells’s ability support HIV replication. ...

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