Browsing Research Articles (Biochemistry) by Title

Browsing Research Articles (Biochemistry) by Title

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  • QTL mapping of mycelial growth and aggressiveness to distinct hosts in Ceratocystis pathogens 
    Fourie, Arista; Van der Nest, Magrieta Aletta; De Vos, Lieschen; Wingfield, Michael J.; Wingfield, Brenda D.; Barnes, Irene (Elsevier, 2019-10)
    Some species of Ceratocystis display strong host specificity, such as C. fimbriata sensu stricto that is restricted to sweet potato (Ipomoea batatas) as host. In contrast, the closely related C. manginecans, infects Acacia ...
  • Qualitative serum organic acid profiles of HIV-infected individuals not on antiretroviral treatment 
    Williams, Aurelia Alvina; Koekemoer, Gerhard; Lindeque, Zander; Reinecke, Carolus J.; Meyer, Debra (Springer, 2012)
    The first application of gas chromatography mass spectrometry (GC–MS) metabolomics to the analysis of organic acid profiles in sera of asymptomatic human immunodeficiency virus (HIV)-infected individuals (n = 18) ...
  • Quantification of outcrossing events in haploid fungi using microsatellite markers 
    Lee, Dong Hyeon; Wingfield, Brenda D.; Roux, Jolanda; Wingfield, Michael J. (MDPI, 2020-04)
    Species in genera of the fungal family Ceratocystidaceae are known to have different mating strategies, including heterothallism and homothallism. Of these, species of Ceratocystis, typified by the pathogen Ceratocystis ...
  • Quantitative chromatin proteomics reveals a dynamic histone posttranslational modification landscape that defines asexual and sexual Plasmodium falciparum parasites 
    Coetzee, Nanika; Sidoli, Simone; Van Biljon, Riette Andele; Painter, Heather; Llinas, Manuel; Garcia, Benjamin A.; Birkholtz, Lyn-Marie (Nature Publishing Group, 2017-04-04)
    Gene expression in Plasmodia integrates post-transcriptional regulation with epigenetic marking of active genomic regions through histone post-translational modifications (PTMs). To generate insights into the importance ...
  • Rabies control in Liberia : joint efforts towards zero by 30 
    Voupawoe, Garmie; Varkpeh, Roland; Kamara, Varney; Sieh, Sonpon; Traore, Abdallah; De Battisti, Cristian; Angot, Angelique; Loureiro, Luis Filipe L. de J.; Soumare, Baba; Dauphin, Gwenaelle; Abebe, Wolde; Coetzer, Andre; Scott, Terence Peter; Nel, Louis Hendrik; Blanton, Jesse; Dacheux, Laurent; Bonas, Simon; Bourhy, Herve; Gourlaouen, Morgane; Leopardi, Stefania; De Benedictis, Paola; Lechenne, Monique; Zinsstag, Jakob; Mauti, Stephanie (Elsevier, 2021-04)
    Despite declaration as a national priority disease, dog rabies remains endemic in Liberia, with surveillance systems and disease control activities still developing. The objective of these initial efforts was to establish ...
  • Rapid detection of pine pathogens Lecanosticta acicola, Dothistroma pini and D. septosporum on needles by probe-based lamp assays 
    Aglietti, Chiara; Meinecke, Colton D.; Ghelardini, Luisa; Barnes, Irene; Van der Nest, Ariska; Villari, Caterina (MDPI, 2021-04-14)
    Needle blights are serious needle fungal diseases affecting pines both in natural and productive forests. Among needle blight agents, the ascomycetes Lecanosticta acicola, Dothistroma pini and D. septosporum are of ...
  • Ras2 is important for growth and pathogenicity in Fusarium circinatum 
    Phasha, Mmatshepho Malekgale; Wingfield, Michael J.; Wingfield, Brenda D.; Coetzee, Martin Petrus Albertus; Hallen-Adams, H.; Fru, Felix Fon; Swalarsk-Parry, Benedicta S.; Yilmaz, Neriman; Duong, Tuan A.; Steenkamp, Emma Theodora (Elsevier, 2021-05)
    In this study, we investigated to possible role of Ras2 in Fusarium circinatum- a fungus that causes pine pitch canker disease on many different pine species and has a wide geographic distribution. This protein is encoded ...
  • Rational in silico design of novel α-glucosidase inhibitory peptides and in vitro evaluation of promising candidates 
    Ibrahim, Mohammed Auwal; Bester, Megan Jean; Neitz, Albert Walter Herman; Gaspar, Anabella Regina Marques (Elsevier, 2018-11)
    Treatment of type 2 diabetes is achieved through the inhibition of carbohydrate hydrolyzing enzymes such as α-glucosidase and α-amylase. The present study was conducted to identify novel α-glucosidase inhibitory peptides ...
  • Re-evaluation of Mycoleptodiscus species and morphologically similar fungi 
    Hernández-Restrepo, M.; Bezerra, J.D.P.; Tan, Y.P.; Wiederhold, N.; Crous, Pedro W.; Guarro, J.; Gené, J. (National Herbarium of the Netherlands, 2019-06)
    Mycoleptodiscus includes plant pathogens, animal opportunists, saprobic and endophytic fungi. The present study presents the first molecular phylogeny and revision of the genus based on four loci, including ITS, LSU, ...
  • A re-evaluation of Penicillium section Canescentia, including the description of five new species 
    Visagie, Cobus M.; Frisvad, J.C.; Houbraken, J.; Visagie, A.; Samson, R.A.; Jacobs, K. (National Herbarium of the Netherlands, 2021-06)
    A survey of Penicillium in the fynbos biome from South Africa resulted in the isolation of 61 species of which 29 were found to be new. In this study we focus on Penicillium section Canescentia, providing a phylogenetic ...
  • Reconsideration of species boundaries and proposed DNA barcodes for Calonectria 
    Liu, QianLi; Li, JieQiong; Wingfield, Michael J.; Duong, Tuan A.; Wingfield, Brenda D.; Crous, Pedro W.; Chen, S.F. (Fungal Biodiversity Centre (CBS), 2020-09)
    Calonectria represents a genus of phytopathogenic ascomycetous fungi with a worldwide distribution. In recent years, there has been an increase in the number of taxonomic studies on these fungi. Currently, there are 169 ...
  • Redefining species limits in the Fusarium fujikuroi species complex 
    Yilmaz, Neriman; Sandoval-Denis, Marcelo; Lombard, L.; Visagie, Cobus M.; Wingfield, Brenda D.; Crous, Pedro W. (Naturalis Biodiversity Center, 2021-06)
    The Fusarium fujikuroi species complex (FFSC) includes more than 60 phylogenetic species (phylospecies) with both phytopathological and clinical importance. Because of their economical relevance, a stable taxonomy and ...
  • Repeat-induced point mutations drive divergence between Fusarium circinatum and its close relatives 
    Van Wyk, Stephanie; Wingfield, Brenda D.; De Vos, Lieschen; Van der Merwe, Nicolaas Albertus (Albie); Santana, Quentin C.; Steenkamp, Emma Theodora (MDPI, 2019-12)
    The Repeat-Induced Point (RIP) mutation pathway is a fungal-specific genome defense mechanism that counteracts the deleterious effects of transposable elements. This pathway permanently mutates its target sequences by ...
  • Reproducible microbial community dynamics of two drinking water systems treating similar source waters 
    Potgieter, Sarah; Dai, Zihan; Havenga, Minette; Vosloo, Solize; Sigudu, Makhosazana; Pinto, Ameet; Venter, S.N. (Stephanus Nicolaas) (American Chemical Society, 2021-06)
    Understanding whether the spatiotemporal dynamics of the drinking water microbiome are reproducible in full-scale drinking water systems is an important step in devising engineering strategies for effectively managing and ...
  • Research in COVID-19 times : the way forward 
    Pepper, Michael Sean; Burton, Stephanie G. (Health and Medical Publishing Group, 2020-08)
    The COVID-19 pandemic has had a major impact on research at universities. Universities around the world, including in South Africa, have been or are still closed as part of national lockdown strategies. Students have not ...
  • A reservoir of ‘historical’ antibiotic resistance genes in remote pristine Antarctic soils 
    Van Goethem, Marc W.; Pierneef, Rian Ewald; Bezuidt, Keoagile Ignatius Oliver; Van de Peer, Yves; Cowan, Don A.; Makhalanyane, Thulani P. (BioMed Central, 2018-02-23)
    BACKGROUND : Soil bacteria naturally produce antibiotics as a competitive mechanism, with a concomitant evolution, and exchange by horizontal gene transfer, of a range of antibiotic resistance mechanisms. Surveys of ...
  • Residual effects caused by a past mycovirus Infection in Fusarium circinatum 
    Zamora-Ballesteros, Cristina; Wingfield, Brenda D.; Wingfield, Michael J.; Martin-Garcia, Jorge; Diez, Julio J. (MDPI, 2021-01)
    Mycoviruses are known to be difficult to cure in fungi but their spontaneous loss occurs commonly. The unexpected disappearance of mycoviruses can be explained by diverse reasons, from methodological procedures to ...
  • Resistance related metabolic pathways for drug target identification in mycobacterium tuberculosis 
    Cloete, Ruben; Oppon, Ekow; Murungi, Edwin; Schubert, Wolf-Dieter; Christoffels, Alan (BioMed Central, 2016-02-08)
    BACKGROUND : Increasing resistance to anti-tuberculosis drugs has driven the need for developing new drugs. Resources such as the tropical disease research (TDR) target database and AssessDrugTarget can help to ...
  • Resistance sniffer : an online tool for prediction of drug resistance patterns of Mycobacterium tuberculosis isolates using next generation sequencing data 
    Muzondiwa, Dillon; Mutshembele, Awelani; Pierneef, Rian Ewald; Reva, Oleg N. (Elsevier, 2020-02)
    The effective control of multidrug resistant tuberculosis (MDR-TB) relies upon the timely diagnosis and correct treatment of all tuberculosis cases. Whole genome sequencing (WGS) has great potential as a method for ...
  • Resisting resistance : is there a solution for malaria? 
    Verlinden, Bianca K.; Louw, Abraham Izak; Birkholtz, Lyn-Marie (Taylor and Francis, 2016-02)
    INTRODUCTION : Currently, widely used antimalarial drugs have a limited clinical lifespan due to parasite resistance development. With resistance continuously rising, antimalarial drug discovery requires strategies to ...