Comparison of the cardiovascular effects of immobilization with three different drug combinations in free-ranging African lions

dc.contributor.authorDonaldson, Ashleigh Claire
dc.contributor.authorMeyer, Leith Carl Rodney
dc.contributor.authorFuller, Andrea
dc.contributor.authorBuss, Peter Erik
dc.contributor.emailu29002495@tuks.co.zaen_US
dc.date.accessioned2024-05-13T11:35:49Z
dc.date.available2024-05-13T11:35:49Z
dc.date.issued2023-01
dc.descriptionDATA AVAILABILITY : The data underlying this article are available in the article and in its online supplementary material.en_US
dc.description.abstractThirty-six free-ranging lions (12 per group) were immobilized with tiletamine–zolazepam (Zoletil 0.6 mg/kg i.m.) plus medetomidine (0.036 mg/kg i.m.) (TZM), ketamine (3.0 mg/kg i.m.) plus medetomidine (0.036 mg/kg i.m.) (KM) or ketamine (1.2 mg/kg i.m.) plus butorphanol (0.24 mg/kg i.m.) plus medetomidine (0.036 mg/kg i.m.) (KBM). During immobilization cardiovascular variables were monitored at 5-minute intervals for a period of 30 minutes. Lions immobilized with all three drug combinations were severely hypertensive. Systolic arterial pressure was higher at initial sampling in lions immobilized with KM (237.3 ± 24.8 mmHg) than in those immobilized with TZM (221.0 ± 18.1 mmHg) or KBM (226.0 ± 20.6 mmHg) and decreased to 205.8 ± 19.4, 197.7 ± 23.7 and 196.3 ± 17.7 mmHg, respectively. Heart rates were within normal ranges for healthy, awake lions and decreased throughout the immobilization regardless of drug combination used. Lions immobilized with TZM had a higher occurrence (66%) of skipped heart beats than those immobilized with KBM (25%). The three drug combinations all caused negative cardiovascular effects, which were less when KBM was used, but adverse enough to warrant further investigations to determine if these effects can be reversed or prevented when these three combinations are used to immobilize free-living lions.en_US
dc.description.departmentCentre for Veterinary Wildlife Studiesen_US
dc.description.departmentParaclinical Sciencesen_US
dc.description.departmentProduction Animal Studiesen_US
dc.description.librarianam2024en_US
dc.description.sdgSDG-03:Good heatlh and well-beingen_US
dc.description.sponsorshipThe Copenhagen Zoo.en_US
dc.description.urihttps://academic.oup.com/conphysen_US
dc.identifier.citationDonaldson, A.C., Meyer, L.C.R., Fuller, A. & Buss, P.E. (2023) Comparison of the cardiovascular effects of immobilization with three different drug combinations in free-ranging African lions. Conservation Physiology 11(1): coac077; DOI:10.1093/conphys/coac077.en_US
dc.identifier.issn2051-1434 (online)
dc.identifier.other10.1093/conphys/coac077
dc.identifier.urihttp://hdl.handle.net/2263/95917
dc.language.isoenen_US
dc.publisherOxford University Pressen_US
dc.rights© The Author(s) 2023. This is an Open Access article distributed under the terms of the Creative Commons Attribution License.en_US
dc.subjectSkipped heart beatsen_US
dc.subjectMedetomidineen_US
dc.subjectHypertensionen_US
dc.subjectHeart rateen_US
dc.subjectLion (Panthera leo)en_US
dc.subjectSDG-03: Good health and well-beingen_US
dc.titleComparison of the cardiovascular effects of immobilization with three different drug combinations in free-ranging African lionsen_US
dc.typeArticleen_US

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