Tryptophan end-tagging confers antifungal activity on a tick-derived peptide by triggering reactive oxygen species production

dc.contributor.authorChiramba, Court Kudakwashe
dc.contributor.authorMoller, Dalton Sharl
dc.contributor.authorLorenz, Christian D.
dc.contributor.authorChirombo, Rumbidzai Ruth
dc.contributor.authorMason, A. James
dc.contributor.authorBester, Megan Jean
dc.contributor.authorGaspar, Anabella Regina Marques
dc.contributor.emailanabella.gaspar@up.ac.zaen_US
dc.date.accessioned2024-07-25T07:57:57Z
dc.date.available2024-07-25T07:57:57Z
dc.date.issued2024-03
dc.descriptionDATA AVAILABILITY STATEMENT : All data supporting the findings of this study are available in the figures and Supporting Information.en_US
dc.descriptionSUPPLEMENTARY MATERIAL : Effect of antifungal agents on cell growth and viability; biofilm preventing activity of AMB, Os−C, and Os− C(W5); biofilm eradicating activity of AMB and Os− C(W5); microscopy images of cells exposed to AMB; and HPLC and MS data for Os−C and Os−C(W5).en_US
dc.description.abstractPlease read abstract in the article.en_US
dc.description.departmentAnatomyen_US
dc.description.departmentBiochemistryen_US
dc.description.departmentGeneticsen_US
dc.description.departmentMicrobiology and Plant Pathologyen_US
dc.description.librarianhj2024en_US
dc.description.sdgSDG-03:Good heatlh and well-beingen_US
dc.description.sponsorshipThe National Research Foundation, the University of Pretoria, the SA-UK Newton Fund Antibiotic Accelerator administered by the Medical Research Council (MRC) and the South African Medical Research Council (SAMRC), the UK Materials and Molecular Modelling Hub which is partially funded by EPSRC and and the UK HPC Materials Chemistry Consortium, which is also funded by EPSRC.en_US
dc.description.urihttps://pubs.acs.org/journal/acsodfen_US
dc.identifier.citationChiramba, C.K., Möller, D.S., Lorenz, C.D. et al. 2024, 'Tryptophan end-tagging confers antifungal activity on a tick-derived peptide by triggering reactive oxygen species production', ACS Omega, vol. 9, no. 13, pp. 15556–15572, doi : 10.1021/acsomega.4c00478.en_US
dc.identifier.issn2470-1343 (online)
dc.identifier.other10.1021/acsomega.4c00478
dc.identifier.urihttp://hdl.handle.net/2263/97229
dc.language.isoenen_US
dc.publisherAmerican Chemical Societyen_US
dc.rights© 2024 The Authors. Published by American Chemical Society. This article is licensed under CC-BY-NC-ND 4.0.en_US
dc.subjectBiofilmsen_US
dc.subjectMembranesen_US
dc.subjectMonomersen_US
dc.subjectPeptides and proteinsen_US
dc.subjectVesiclesen_US
dc.subjectAntimicrobial peptide (AMP)en_US
dc.subjectTryptophan end-taggingen_US
dc.subjectAntifungal activityen_US
dc.subjectPhysiological salt environmentsen_US
dc.subjectSDG-03: Good health and well-beingen_US
dc.titleTryptophan end-tagging confers antifungal activity on a tick-derived peptide by triggering reactive oxygen species productionen_US
dc.typeArticleen_US

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