In-silico reverse docking and in-vitro studies identified curcumin, 18α-glycyrrhetinic acid, rosmarinic acid, and quercetin as inhibitors of α-glucosidase and pancreatic α-amylase and lipid accumulation in HepG2 cells, important type 2 diabetes targets
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Date
Authors
Tshiyoyo, Kadima Samuel
Bester, Megan Jean
Serem, June Cheptoo
Apostolides, Zeno
Journal Title
Journal ISSN
Volume Title
Publisher
Elsevier
Abstract
Please read abstract in the article.
Description
Keywords
α-amylase, α-glucosidase, Herbal compounds, Hepatic lipid accumulation, In-vitro cytotoxicity, Reverse molecular docking, Type 2 diabetes mellitus (T2DM)
Sustainable Development Goals
SDG-03: Good health and well-being
Citation
Tshiyoyo, K.S., Bester, M.J., Serem, J.C. et al. 2022, 'In-silico reverse docking and in-vitro studies identified curcumin, 18α-glycyrrhetinic acid, rosmarinic acid, and quercetin as inhibitors of α-glucosidase and pancreatic α-amylase and lipid accumulation in HepG2 cells, important type 2 diabetes targets', Journal of Molecular Structure, vol. 1266, art. 133492, pp. 1-10, doi : 10.1016/j.molstruc.2022.133492.