The dataset for the inflammatory response during experimental infection and treatment of dogs with Babesia rossi
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Date
Authors
Atkinson, Brogan Kim
Thompson, P.N. (Peter N.)
Van Zyl, Estee
Goddard, Amelia
Rautenbach, Yolandi
Schoeman, Johan P.
Mukorera, Varaidzo
Leisewitz, Andrew L.
Journal Title
Journal ISSN
Volume Title
Publisher
Elsevier
Abstract
Babesia rossi causes severe morbidity and mortality in dogs in
sub-Saharan Africa. This was an experimental study designed
to observe systemic changes caused by Babesia rossi infection
within a canine disease model as well as investigate the influence of inoculum dose and treatment on the progression
of inflammation and clinical disease. Six healthy male beagle dogs formed the study population, one dog was splenectomised and used to raise the infectious inoculum, three
were administered a high B. rossi infectious dose and two
a low infectious dose. Clinical examination, complete blood
count (CBC) and C-reactive protein (CRP) were determined
daily. Cytokines were quantified on stored plasma collected
during the study, using a canine specific cytokine magnetic
bead panel (Milliplex©). The experiment was terminated, and
treatment administered once predetermined experimental or
humane endpoints were reached. The data and information
provided in the following article is the summary of all data
Description
Keywords
Cytokines, C-reactive protein, Leukocytes, Treatment, Parasitemia, Anaemia, Babesia rossi
Sustainable Development Goals
Citation
Brogan Kim Atkinson, Peter Thompson, Estee Van Zyl, Amelia Goddard, Yolandi Rautenbach, Johan Petrus Schoeman, Varaidzo Mukorera, Andrew Leisewitz,
The dataset for the inflammatory response during experimental infection and treatment of dogs with Babesia rossi,
Data in Brief, Volume 45, 2022, ISSN 2352-3409, https://doi.org/10.1016/j.dib.2022.108475.