Abstract:
Babesia rossi causes severe morbidity and mortality in dogs in
sub-Saharan Africa. This was an experimental study designed
to observe systemic changes caused by Babesia rossi infection
within a canine disease model as well as investigate the influence of inoculum dose and treatment on the progression
of inflammation and clinical disease. Six healthy male beagle dogs formed the study population, one dog was splenectomised and used to raise the infectious inoculum, three
were administered a high B. rossi infectious dose and two
a low infectious dose. Clinical examination, complete blood
count (CBC) and C-reactive protein (CRP) were determined
daily. Cytokines were quantified on stored plasma collected
during the study, using a canine specific cytokine magnetic
bead panel (Milliplex©). The experiment was terminated, and
treatment administered once predetermined experimental or
humane endpoints were reached. The data and information
provided in the following article is the summary of all data
