dc.contributor.author |
Ebadi, Mehrshad
|
|
dc.contributor.author |
Bafort, Quinten
|
|
dc.contributor.author |
Mizrachi, Eshchar
|
|
dc.contributor.author |
Audenaert, Pieter
|
|
dc.contributor.author |
Simoens, Pieter
|
|
dc.contributor.author |
Van Montagu, Marc
|
|
dc.contributor.author |
Bonte, Dries
|
|
dc.contributor.author |
Van de Peer, Yves
|
|
dc.date.accessioned |
2024-10-02T13:16:39Z |
|
dc.date.available |
2024-10-02T13:16:39Z |
|
dc.date.issued |
2023-10-03 |
|
dc.description.abstract |
The importance of whole-genome
duplication (WGD) for evolution is controversial.
Whereas some view WGD mainly as detrimental and an evolutionary dead end, there
is growing evidence that polyploidization can help overcome environmental change,
stressful conditions, or periods of extinction. However, despite much research, the mechanistic
underpinnings of why and how polyploids might be able to outcompete or
outlive nonpolyploids at times of environmental upheaval remain elusive, especially for
autopolyploids, in which heterosis effects are limited. On the longer term, WGD might
increase both mutational and environmental robustness due to redundancy and increased
genetic variation, but on the short—or even immediate—term, selective advantages of
WGDs are harder to explain. Here, by duplicating artificially generated Gene Regulatory
Networks (GRNs), we show that duplicated GRNs—and thus duplicated genomes—
show higher signal output variation than nonduplicated GRNs. This increased variation
leads to niche expansion and can provide polyploid populations with substantial
advantages to survive environmental turmoil. In contrast, under stable environments,
GRNs might be maladaptive to changes, a phenomenon that is exacerbated in duplicated
GRNs. We believe that these results provide insights into how genome duplication and
(auto)polyploidy might help organisms to adapt quickly to novel conditions and to
survive ecological uproar or even cataclysmic events. |
en_US |
dc.description.department |
Biochemistry, Genetics and Microbiology (BGM) |
en_US |
dc.description.librarian |
am2024 |
en_US |
dc.description.sdg |
SDG-15:Life on land |
en_US |
dc.description.sponsorship |
The European Research Council under the European Union’s Horizon 2020 research and innovation program and Ghent University. |
en_US |
dc.description.uri |
http://www.pnas.org |
en_US |
dc.identifier.citation |
Ebadi, M., Bafort, Q., Mizrachi, E. et al. 2023, 'The duplication of genomes and genetic networks and its potential for evolutionary adaptation and survival during
environmental turmoil', Proceedings of the National Academy of Sciences (PNAS), vol. 120, no. 41, art. e2307289120. https://DOI.org/10.1073/pnas.2307289120. |
en_US |
dc.identifier.issn |
0027-8424 (print) |
|
dc.identifier.issn |
1091-6490 (online) |
|
dc.identifier.other |
10.1073/pnas.2307289120 |
|
dc.identifier.uri |
http://hdl.handle.net/2263/98453 |
|
dc.language.iso |
en |
en_US |
dc.publisher |
National Academy of Sciences |
en_US |
dc.rights |
© 2023 the Author(s).
This article is distributed under Creative Commons
Attribution-NonCommercial-
NoDerivatives
License 4.0
(CC BY-NC-ND). |
en_US |
dc.subject |
Polyploidy |
en_US |
dc.subject |
Environmental turmoil |
en_US |
dc.subject |
Cataclysmic events |
en_US |
dc.subject |
Whole-genome duplication (WGD) |
en_US |
dc.subject |
Gene regulatory networks (GRNs) |
en_US |
dc.subject |
SDG-15: Life on land |
en_US |
dc.title |
The duplication of genomes and genetic networks and its potential for evolutionary adaptation and survival during environmental turmoil |
en_US |
dc.type |
Article |
en_US |