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dc.contributor.author | Robinson, Liam![]() |
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dc.contributor.author | Abreu, Lucas Guimaraes![]() |
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dc.contributor.author | Fonseca, Felipe Paiva![]() |
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dc.contributor.author | Hunter, K.D. (Keith)![]() |
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dc.contributor.author | Ambele, Melvin Anyasi![]() |
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dc.contributor.author | Van Heerden, Willem Francois Petrus![]() |
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dc.date.accessioned | 2024-08-07T07:34:00Z | |
dc.date.available | 2024-08-07T07:34:00Z | |
dc.date.issued | 2024-03 | |
dc.description | DATA AVAILABILITY STATEMENT : The data that support the findings of this study are available on request from the corresponding author. The data are not publicly available due to privacy or ethical restrictions. | en_US |
dc.description | SUPPLEMENTARY TABLE 1. Data from included studies. | en_US |
dc.description.abstract | BACKGROUND : Ameloblastic carcinoma (AC) is the most common odontogenic malignancy, constituting approximately 30% of cases in this category. Literature is sparse on malignant odontogenic neoplasms, with a large proportion of current knowledge derived from case reports or small case series. METHODS : A systematic review of case series/case reports of AC was conducted following the Preferred Reporting Items for Systematic Reviews and Meta-analyses (PRISMA) Statement guidelines. Demographic and clinical information, including duration of the lesion, location, clinical presentation and radiologic features, were analysed. Additionally, the origin of the lesion (primary/secondary), Ki-67 proliferation index, treatment performed, metastasis, tumour recurrence and prognosis were collected for analysis. RESULTS : A total of 126 studies, including 285 individual cases of AC, were included in this review. Patients presented with a near-equal distribution of painless and painful swellings. ACs presented at a median age of 45 years, with a male-to-female ratio of 1:2. The mandible was most frequently involved, with rare cases extending to involve more than one region, including crossing the midline. Although most lesions presented with poorly-demarcated borders (52.6%), unilocular lesions with well-demarcated borders (47.4%) comprised a substantial number in the sample. The proliferation index was only reported in 27 cases, with a mean score of 42% and a wide range. The probability of tumour recurrence increased, and the survival probability decreased with prolonged follow-up duration. CONCLUSION : This study provides more comprehensive, up-to-date descriptive data on these rare odontogenic malignancies, aiding clinicians and Pathologists with the diagnosis and surgeons in their management of cases. | en_US |
dc.description.department | Oral Pathology and Oral Biology | en_US |
dc.description.librarian | hj2024 | en_US |
dc.description.sdg | SDG-03:Good heatlh and well-being | en_US |
dc.description.uri | http://wileyonlinelibrary.com/journal/jop | en_US |
dc.identifier.citation | Robinson, L., Abreu, L.G., Fonseca, F.P., Hunter, K.D., Ambele, M.A. & Van Heerden, W.F.P. Ameloblastic carcinoma: A systematic review. Journal of Oral Pathology and Medicine 2024; 53 (3) : 174‐181. doi: 10.1111/jop.13517. | en_US |
dc.identifier.issn | 0904-2512 (print) | |
dc.identifier.issn | 1600-0714 (online) | |
dc.identifier.other | 10.1111/jop.13517. | |
dc.identifier.uri | http://hdl.handle.net/2263/97477 | |
dc.language.iso | en | en_US |
dc.publisher | Wiley | en_US |
dc.rights | © 2024 The Authors. Journal of Oral Pathology & Medicine published by John Wiley & Sons Ltd. This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License. | en_US |
dc.subject | Ameloblastic carcinoma | en_US |
dc.subject | Preferred reporting items for systematic review and meta-analysis (PRISMA) | en_US |
dc.subject | Head and neck cancer | en_US |
dc.subject | Odontogenic neoplasms | en_US |
dc.subject | Recurrence rates | en_US |
dc.subject | Survival probability | en_US |
dc.subject | SDG-03: Good health and well-being | en_US |
dc.title | Ameloblastic carcinoma : a systematic review | en_US |
dc.type | Article | en_US |