In-silico reverse docking and in-vitro studies identified curcumin, 18α-glycyrrhetinic acid, rosmarinic acid, and quercetin as inhibitors of α-glucosidase and pancreatic α-amylase and lipid accumulation in HepG2 cells, important type 2 diabetes targets

Tshiyoyo, Kadima Samuel; Bester, Megan Jean; Serem, June Cheptoo; Apostolides, Zeno

dc.contributor.author	Tshiyoyo, Kadima Samuel
dc.contributor.author	Bester, Megan Jean
dc.contributor.author	Serem, June Cheptoo
dc.contributor.author	Apostolides, Zeno
dc.date.accessioned	2023-02-17T06:50:16Z
dc.date.issued	2022-10
dc.description.abstract	Please read abstract in the article.	en_US
dc.description.department	Anatomy	en_US
dc.description.department	Biochemistry	en_US
dc.description.department	Genetics	en_US
dc.description.department	Microbiology and Plant Pathology	en_US
dc.description.embargo	2023-06-22
dc.description.librarian	hj2023	en_US
dc.description.sponsorship	The National Research Foundation (NRF) of South Africa.	en_US
dc.description.uri	http://www.elsevier.com/locate/molstr	en_US
dc.identifier.citation	Tshiyoyo, K.S., Bester, M.J., Serem, J.C. et al. 2022, 'In-silico reverse docking and in-vitro studies identified curcumin, 18α-glycyrrhetinic acid, rosmarinic acid, and quercetin as inhibitors of α-glucosidase and pancreatic α-amylase and lipid accumulation in HepG2 cells, important type 2 diabetes targets', Journal of Molecular Structure, vol. 1266, art. 133492, pp. 1-10, doi : 10.1016/j.molstruc.2022.133492.	en_US
dc.identifier.issn	0022-2860 (print)
dc.identifier.issn	1872-8014 (online)
dc.identifier.other	10.1016/j.molstruc.2022.133492
dc.identifier.uri	https://repository.up.ac.za/handle/2263/89650
dc.language.iso	en	en_US
dc.publisher	Elsevier	en_US
dc.rights	© 2022 Elsevier B.V. All rights reserved. Notice : this is the author’s version of a work that was accepted for publication in Journal of Molecular Structure. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. A definitive version was subsequently published in Journal of Molecular Structure, vol. 1266, art. 133492, pp. 1-10, doi : 10.1016/j.molstruc.2022.133492.	en_US
dc.subject	α-amylase	en_US
dc.subject	α-glucosidase	en_US
dc.subject	Herbal compounds	en_US
dc.subject	Hepatic lipid accumulation	en_US
dc.subject	In-vitro cytotoxicity	en_US
dc.subject	Reverse molecular docking	en_US
dc.subject	Type 2 diabetes mellitus (T2DM)	en_US
dc.title	In-silico reverse docking and in-vitro studies identified curcumin, 18α-glycyrrhetinic acid, rosmarinic acid, and quercetin as inhibitors of α-glucosidase and pancreatic α-amylase and lipid accumulation in HepG2 cells, important type 2 diabetes targets	en_US
dc.type	Postprint Article	en_US