dc.contributor.author |
Cheng, Hang
|
|
dc.contributor.author |
Sebaa, Rajaa
|
|
dc.contributor.author |
Malholtra, Nikita
|
|
dc.contributor.author |
Lacoste, Baptiste
|
|
dc.contributor.author |
El Hankouri, Ziyad
|
|
dc.contributor.author |
Kirby, Alexia
|
|
dc.contributor.author |
Bennett, Nigel Charles
|
|
dc.contributor.author |
Van Jaarsveld, Barry
|
|
dc.contributor.author |
Hart, Daniel William
|
|
dc.contributor.author |
Tattersall, Glenn J.
|
|
dc.contributor.author |
Harper, Mary-Ellen
|
|
dc.contributor.author |
Pamenter, Matthew E.
|
|
dc.date.accessioned |
2022-09-22T13:04:16Z |
|
dc.date.available |
2022-09-22T13:04:16Z |
|
dc.date.issued |
2021-11-23 |
|
dc.description.abstract |
Naked mole-rats are among the most hypoxia-tolerant mammals. During hypoxia, their body
temperature (Tb) decreases via unknown mechanisms to conserve energy. In small mammals,
non-shivering thermogenesis in brown adipose tissue (BAT) is critical to Tb regulation;
therefore, we hypothesize that hypoxia decreases naked mole-rat BAT thermogenesis. To
test this, we measure changes in Tb during normoxia and hypoxia (7% O2; 1–3 h). We report
that interscapular thermogenesis is high in normoxia but ceases during hypoxia, and Tb
decreases. Furthermore, in BAT from animals treated in hypoxia, UCP1 and mitochondrial
complexes I-V protein expression rapidly decrease, while mitochondria undergo fission, and
apoptosis and mitophagy are inhibited. Finally, UCP1 expression decreases in hypoxia in three
other social African mole-rat species, but not a solitary species. These findings suggest that
the ability to rapidly down-regulate thermogenesis to conserve oxygen in hypoxia may have
evolved preferentially in social species. |
en_US |
dc.description.department |
Zoology and Entomology |
en_US |
dc.description.librarian |
am2022 |
en_US |
dc.description.sponsorship |
An NSERC Discovery grants, a Canada Research Chair and an University of Ottawa Research Chair. Collection and housing of mole-rats in Africa were funded by a SARChI grant. |
en_US |
dc.description.uri |
http://www.nature.com/naturecommunications |
en_US |
dc.identifier.citation |
Cheng, H., Sebaa, R., Malholtra, N. et al. 2021, 'Naked mole-rat brown fat thermogenesis is
diminished during hypoxia through a rapid
decrease in UCP1', Nature Communications, vol. 12, art. 6801, pp. 1-14, doi : 10.1038/s41467-021-27170-2. |
en_US |
dc.identifier.issn |
2041-1723 (online) |
|
dc.identifier.other |
10.1038/s41467-021-27170-2 |
|
dc.identifier.uri |
https://repository.up.ac.za/handle/2263/87301 |
|
dc.language.iso |
en |
en_US |
dc.publisher |
Nature Publishing Group |
en_US |
dc.rights |
© The Author(s) 2021.
This article is licensed under a Creative Commons
Attribution 4.0 International License. |
en_US |
dc.subject |
Naked |
en_US |
dc.subject |
Hypoxia |
en_US |
dc.subject |
Temperature |
en_US |
dc.subject |
Naked mole-rat (Heterocephalus glaber) |
en_US |
dc.subject |
Naked mole-rats (NMRs) |
en_US |
dc.title |
Naked mole-rat brown fat thermogenesis is diminished during hypoxia through a rapid decrease in UCP1 |
en_US |
dc.type |
Article |
en_US |