dc.contributor.author |
Chivandi, Eliton
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dc.contributor.author |
Mhosva, Yvonne
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|
dc.contributor.author |
Nyakudya, Trevor Tapiwa
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|
dc.contributor.author |
Nkomozepi, Pilani
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dc.date.accessioned |
2022-09-07T07:40:52Z |
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dc.date.available |
2022-09-07T07:40:52Z |
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dc.date.issued |
2022-01 |
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dc.description.abstract |
BACKGROUND : Ficus thonningii extracts exhibit hypoglycaemic, hypolipidaemic and antioxidant activitiese investigated the potential of methanolic F. thonningii stem-bark extracts (MEFT) to protect growing Sprague-Dawley (SD) against high-fructose diet-induced Metabolic Derangements (MD) in a model mimicking childreenic diets.
METHODS : Eighty (40 males; 40 females) 21-days old SD rat pups were randomly allocated to and administered, for 8 weeks, five treatment regimens: 1-standard rat chow (SC)+water (PW), 2-SC+20% (w/v) fructose solution (FS), 3-SC+FS+fenofibrate at 100 mg/kg bwt/ day, 4-SC+FS+low dose MEFT (LD; 50 mg/kg bwt/day) and 5-SC+FS+high dose MEFT (HD; 500 mg/kg bwt/ day). Body weight, glucose load tolerance, fasting blood glucose and triglyceride, plasma insulin concentration, sensitivity to insulin, liver mass and fat content, steatosis and inflammation were determined.
RESULTS : Fructose had no effect on the rats’ growth, glucose and insulin concentration, glucose tolerance and insulin sensitivity (P>0.05) but increased triglycerides in females; induced hepatic microsteatosis and inflammation in both sexes but macrosteatosis in females (P<0.05). In females, MEFT prevented fructose- induced plasma triglyceride increase. Low dose MEFT increased liver lipid content in females (P<0.05). The MEFT protected the rats against hepatic steatosis and inflammation but fenofibrate protected against hepatic microsteatosis.
CONCLUSION : MEFT can d as prxis against dietary fructose-induced elements of MD but caution musaken as low dose MEFT increases hepatic lipid acc in females predisposing to fatty liver disease. |
en_US |
dc.description.department |
Physiology |
en_US |
dc.description.librarian |
hj2022 |
en_US |
dc.description.sponsorship |
The National Research Foundation, South Africa and Wits University Faculty of Health Sciences Research Committee. |
en_US |
dc.description.uri |
https://www.sysrevpharm.org/about.html |
en_US |
dc.identifier.citation |
Chivandi, E., Mhosva, Y., Nyakudya, T. et al. 2022, 'Ficus thonningii stem bark extracts prevent high fructose diet induced increased plasma triglyceride concentration, hepatic steatosis and inflammation in growing Sprague-Dawley rats', Systematic Reviews in Pharmacy, vol. 13, no. 2, pp. 205-212, doi : 10.31858/0975-8453.13.2.205-212. |
en_US |
dc.identifier.issn |
0975-8453 (print) |
|
dc.identifier.issn |
0976-2779 (online) |
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dc.identifier.other |
10.31858/0975-8453.13.2.205-212 |
|
dc.identifier.uri |
https://repository.up.ac.za/handle/2263/87094 |
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dc.language.iso |
en |
en_US |
dc.publisher |
Medknow Publications |
en_US |
dc.rights |
© 2022 Systematic Reviews in Pharmacy All Rights Reserved. The articles in Systematic Reviews in Pharmacy are open access articles licensed under the terms of the Creative Commons Attribution Non-Commercial License. |
en_US |
dc.subject |
Ficus thonningii extracts |
en_US |
dc.subject |
Sprague-Dawley rat (Rattus norvegicus) |
en_US |
dc.subject |
Metabolic derangement |
en_US |
dc.subject |
Ethnomedicine |
en_US |
dc.subject |
Obesity |
en_US |
dc.subject |
Lipid profile |
en_US |
dc.subject |
Liver disease |
en_US |
dc.title |
Ficus thonningii stem bark extracts prevent high fructose diet induced increased plasma triglyceride concentration, hepatic steatosis and inflammation in growing Sprague-Dawley rats |
en_US |
dc.type |
Article |
en_US |