Ficus thonningii stem bark extracts prevent high fructose diet induced increased plasma triglyceride concentration, hepatic steatosis and inflammation in growing Sprague-Dawley rats

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Authors

Chivandi, Eliton
Mhosva, Yvonne
Nyakudya, Trevor Tapiwa
Nkomozepi, Pilani

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Medknow Publications

Abstract

BACKGROUND : Ficus thonningii extracts exhibit hypoglycaemic, hypolipidaemic and antioxidant activitiese investigated the potential of methanolic F. thonningii stem-bark extracts (MEFT) to protect growing Sprague-Dawley (SD) against high-fructose diet-induced Metabolic Derangements (MD) in a model mimicking childreenic diets. METHODS : Eighty (40 males; 40 females) 21-days old SD rat pups were randomly allocated to and administered, for 8 weeks, five treatment regimens: 1-standard rat chow (SC)+water (PW), 2-SC+20% (w/v) fructose solution (FS), 3-SC+FS+fenofibrate at 100 mg/kg bwt/ day, 4-SC+FS+low dose MEFT (LD; 50 mg/kg bwt/day) and 5-SC+FS+high dose MEFT (HD; 500 mg/kg bwt/ day). Body weight, glucose load tolerance, fasting blood glucose and triglyceride, plasma insulin concentration, sensitivity to insulin, liver mass and fat content, steatosis and inflammation were determined. RESULTS : Fructose had no effect on the rats’ growth, glucose and insulin concentration, glucose tolerance and insulin sensitivity (P>0.05) but increased triglycerides in females; induced hepatic microsteatosis and inflammation in both sexes but macrosteatosis in females (P<0.05). In females, MEFT prevented fructose- induced plasma triglyceride increase. Low dose MEFT increased liver lipid content in females (P<0.05). The MEFT protected the rats against hepatic steatosis and inflammation but fenofibrate protected against hepatic microsteatosis. CONCLUSION : MEFT can d as prxis against dietary fructose-induced elements of MD but caution musaken as low dose MEFT increases hepatic lipid acc in females predisposing to fatty liver disease.

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Ficus thonningii extracts, Sprague-Dawley rat (Rattus norvegicus), Metabolic derangement, Ethnomedicine, Obesity, Lipid profile, Liver disease

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Citation

Chivandi, E., Mhosva, Y., Nyakudya, T. et al. 2022, 'Ficus thonningii stem bark extracts prevent high fructose diet induced increased plasma triglyceride concentration, hepatic steatosis and inflammation in growing Sprague-Dawley rats', Systematic Reviews in Pharmacy, vol. 13, no. 2, pp. 205-212, doi : 10.31858/0975-8453.13.2.205-212.