Ficus thonningii stem bark extracts prevent high fructose diet induced increased plasma triglyceride concentration, hepatic steatosis and inflammation in growing Sprague-Dawley rats

dc.contributor.authorChivandi, Eliton
dc.contributor.authorMhosva, Yvonne
dc.contributor.authorNyakudya, Trevor Tapiwa
dc.contributor.authorNkomozepi, Pilani
dc.date.accessioned2022-09-07T07:40:52Z
dc.date.available2022-09-07T07:40:52Z
dc.date.issued2022-01
dc.description.abstractBACKGROUND : Ficus thonningii extracts exhibit hypoglycaemic, hypolipidaemic and antioxidant activitiese investigated the potential of methanolic F. thonningii stem-bark extracts (MEFT) to protect growing Sprague-Dawley (SD) against high-fructose diet-induced Metabolic Derangements (MD) in a model mimicking childreenic diets. METHODS : Eighty (40 males; 40 females) 21-days old SD rat pups were randomly allocated to and administered, for 8 weeks, five treatment regimens: 1-standard rat chow (SC)+water (PW), 2-SC+20% (w/v) fructose solution (FS), 3-SC+FS+fenofibrate at 100 mg/kg bwt/ day, 4-SC+FS+low dose MEFT (LD; 50 mg/kg bwt/day) and 5-SC+FS+high dose MEFT (HD; 500 mg/kg bwt/ day). Body weight, glucose load tolerance, fasting blood glucose and triglyceride, plasma insulin concentration, sensitivity to insulin, liver mass and fat content, steatosis and inflammation were determined. RESULTS : Fructose had no effect on the rats’ growth, glucose and insulin concentration, glucose tolerance and insulin sensitivity (P>0.05) but increased triglycerides in females; induced hepatic microsteatosis and inflammation in both sexes but macrosteatosis in females (P<0.05). In females, MEFT prevented fructose- induced plasma triglyceride increase. Low dose MEFT increased liver lipid content in females (P<0.05). The MEFT protected the rats against hepatic steatosis and inflammation but fenofibrate protected against hepatic microsteatosis. CONCLUSION : MEFT can d as prxis against dietary fructose-induced elements of MD but caution musaken as low dose MEFT increases hepatic lipid acc in females predisposing to fatty liver disease.en_US
dc.description.departmentPhysiologyen_US
dc.description.librarianhj2022en_US
dc.description.sponsorshipThe National Research Foundation, South Africa and Wits University Faculty of Health Sciences Research Committee.en_US
dc.description.urihttps://www.sysrevpharm.org/about.htmlen_US
dc.identifier.citationChivandi, E., Mhosva, Y., Nyakudya, T. et al. 2022, 'Ficus thonningii stem bark extracts prevent high fructose diet induced increased plasma triglyceride concentration, hepatic steatosis and inflammation in growing Sprague-Dawley rats', Systematic Reviews in Pharmacy, vol. 13, no. 2, pp. 205-212, doi : 10.31858/0975-8453.13.2.205-212.en_US
dc.identifier.issn0975-8453 (print)
dc.identifier.issn0976-2779 (online)
dc.identifier.other10.31858/0975-8453.13.2.205-212
dc.identifier.urihttps://repository.up.ac.za/handle/2263/87094
dc.language.isoenen_US
dc.publisherMedknow Publicationsen_US
dc.rights© 2022 Systematic Reviews in Pharmacy All Rights Reserved. The articles in Systematic Reviews in Pharmacy are open access articles licensed under the terms of the Creative Commons Attribution Non-Commercial License.en_US
dc.subjectFicus thonningii extractsen_US
dc.subjectSprague-Dawley rat (Rattus norvegicus)en_US
dc.subjectMetabolic derangementen_US
dc.subjectEthnomedicineen_US
dc.subjectObesityen_US
dc.subjectLipid profileen_US
dc.subjectLiver diseaseen_US
dc.titleFicus thonningii stem bark extracts prevent high fructose diet induced increased plasma triglyceride concentration, hepatic steatosis and inflammation in growing Sprague-Dawley ratsen_US
dc.typeArticleen_US

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