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dc.contributor.author | Phillips, Justin | |
dc.contributor.author | Venter, Jaco-Louis | |
dc.contributor.author | Atanasova, Maria Todorova | |
dc.contributor.author | Wesley-Smith, James | |
dc.contributor.author | Oosthuizen, Hester | |
dc.contributor.author | Emmambux, Mohammad Naushad | |
dc.contributor.author | Du Toit, Elizabeth Louisa | |
dc.contributor.author | Focke, Walter Wilhelm | |
dc.date.accessioned | 2021-08-04T11:47:36Z | |
dc.date.available | 2021-08-04T11:47:36Z | |
dc.date.issued | 2020-03 | |
dc.description.abstract | Safe application of water-insoluble acaricides requires fast release from solid dosage systems into aquatic environments. Dextrin is a water-soluble form of partially hydrolyzed starch, which may be used as matrix material for these systems if retrogradation can be inhibited by the inclusion of nanofillers. Several glycerol-plasticized thermoplastic dextrin-based nanocomposites were prepared with a twin-screw extrusion-compounding process. The nanofillers included a layered double hydroxide (LDH), cellulose nanofibers (CNF), and stearic acid. The time-dependent retrogradation of the compounds was monitored by X-ray diffraction (XRD) and dynamic mechanical thermal analysis (DMA). XRD showed that composite samples that included stearic acid in the formulation led to the formation of an amylose-lipid complex and a stable crystallinity during aging. The most promising nanocomposite included both stearic acid and CNF. It was selected as the carrier material for the water-insoluble acaricide Amitraz. Fast release rates were observed for composites containing 5, 10, and 20% (w/w) of the pesticide. A significant reduction in the particle size of the released Amitraz powder was observed, which is ascribed to the high-temperature compounding procedure. | en_ZA |
dc.description.department | Chemical Engineering | en_ZA |
dc.description.department | Consumer Science | en_ZA |
dc.description.department | Food Science | en_ZA |
dc.description.librarian | hj2021 | en_ZA |
dc.description.sponsorship | PAMSA and the Department of Science and Innovation | en_ZA |
dc.description.uri | https://pubs.acs.org/journal/aamick | en_ZA |
dc.identifier.citation | Phillips, J., Venter, J., Atanasova, M.T. et al. 2020, 'Dextrin nanocomposites as matrices for solid dosage forms', ACS Applied Materials and Interfaces 2020, 12, 14, 16969–16977. | en_ZA |
dc.identifier.issn | 1944-8244 (print) | |
dc.identifier.issn | 1944-8252 (online) | |
dc.identifier.other | 10.1021/acsami.0c02061 | |
dc.identifier.uri | http://hdl.handle.net/2263/81143 | |
dc.language.iso | en | en_ZA |
dc.publisher | American Chemical Society | en_ZA |
dc.rights | © 2020 American Chemical Society | en_ZA |
dc.subject | Layered double hydroxide (LDH) | en_ZA |
dc.subject | Cellulose nanofibers (CNF) | en_ZA |
dc.subject | Stearic acid | en_ZA |
dc.subject | X-ray diffraction (XRD) | en_ZA |
dc.subject | Dynamic mechanical thermal analysis (DMA) | en_ZA |
dc.subject | Dextrin | en_ZA |
dc.subject | Solid dosage form | en_ZA |
dc.subject | Acaricide | en_ZA |
dc.subject | Themoplastic starch | en_ZA |
dc.title | Dextrin nanocomposites as matrices for solid dosage forms | en_ZA |
dc.type | Postprint Article | en_ZA |