Dextrin nanocomposites as matrices for solid dosage forms
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Date
Authors
Phillips, Justin
Venter, Jaco-Louis
Atanasova, Maria Todorova
Wesley-Smith, James
Oosthuizen, Hester
Emmambux, Mohammad Naushad
Du Toit, Elizabeth Louisa
Focke, Walter Wilhelm
Journal Title
Journal ISSN
Volume Title
Publisher
American Chemical Society
Abstract
Safe application of water-insoluble acaricides requires fast release from solid dosage systems into aquatic environments. Dextrin is a water-soluble form of partially hydrolyzed starch, which may be used as matrix material for these systems if retrogradation can be inhibited by the inclusion of nanofillers. Several glycerol-plasticized thermoplastic dextrin-based nanocomposites were prepared with a twin-screw extrusion-compounding process. The nanofillers included a layered double hydroxide (LDH), cellulose nanofibers (CNF), and stearic acid. The time-dependent retrogradation of the compounds was monitored by X-ray diffraction (XRD) and dynamic mechanical thermal analysis (DMA). XRD showed that composite samples that included stearic acid in the formulation led to the formation of an amylose-lipid complex and a stable crystallinity during aging. The most promising nanocomposite included both stearic acid and CNF. It was selected as the carrier material for the water-insoluble acaricide Amitraz. Fast release rates were observed for composites containing 5, 10, and 20% (w/w) of the pesticide. A significant reduction in the particle size of the released Amitraz powder was observed, which is ascribed to the high-temperature compounding procedure.
Description
Keywords
Layered double hydroxide (LDH), Cellulose nanofibers (CNF), Stearic acid, X-ray diffraction (XRD), Dynamic mechanical thermal analysis (DMA), Dextrin, Solid dosage form, Acaricide, Themoplastic starch
Sustainable Development Goals
Citation
Phillips, J., Venter, J., Atanasova, M.T. et al. 2020, 'Dextrin nanocomposites as matrices for solid dosage forms', ACS Applied Materials and Interfaces 2020, 12, 14, 16969–16977.