Dextrin nanocomposites as matrices for solid dosage forms

dc.contributor.authorPhillips, Justin
dc.contributor.authorVenter, Jaco-Louis
dc.contributor.authorAtanasova, Maria Todorova
dc.contributor.authorWesley-Smith, James
dc.contributor.authorOosthuizen, Hester
dc.contributor.authorEmmambux, Mohammad Naushad
dc.contributor.authorDu Toit, Elizabeth Louisa
dc.contributor.authorFocke, Walter Wilhelm
dc.contributor.emailelizbe.dutoit@up.ac.zaen_ZA
dc.date.accessioned2021-08-04T11:47:36Z
dc.date.available2021-08-04T11:47:36Z
dc.date.issued2020-03
dc.description.abstractSafe application of water-insoluble acaricides requires fast release from solid dosage systems into aquatic environments. Dextrin is a water-soluble form of partially hydrolyzed starch, which may be used as matrix material for these systems if retrogradation can be inhibited by the inclusion of nanofillers. Several glycerol-plasticized thermoplastic dextrin-based nanocomposites were prepared with a twin-screw extrusion-compounding process. The nanofillers included a layered double hydroxide (LDH), cellulose nanofibers (CNF), and stearic acid. The time-dependent retrogradation of the compounds was monitored by X-ray diffraction (XRD) and dynamic mechanical thermal analysis (DMA). XRD showed that composite samples that included stearic acid in the formulation led to the formation of an amylose-lipid complex and a stable crystallinity during aging. The most promising nanocomposite included both stearic acid and CNF. It was selected as the carrier material for the water-insoluble acaricide Amitraz. Fast release rates were observed for composites containing 5, 10, and 20% (w/w) of the pesticide. A significant reduction in the particle size of the released Amitraz powder was observed, which is ascribed to the high-temperature compounding procedure.en_ZA
dc.description.departmentChemical Engineeringen_ZA
dc.description.departmentConsumer Scienceen_ZA
dc.description.departmentFood Scienceen_ZA
dc.description.librarianhj2021en_ZA
dc.description.sponsorshipPAMSA and the Department of Science and Innovationen_ZA
dc.description.urihttps://pubs.acs.org/journal/aamicken_ZA
dc.identifier.citationPhillips, J., Venter, J., Atanasova, M.T. et al. 2020, 'Dextrin nanocomposites as matrices for solid dosage forms', ACS Applied Materials and Interfaces 2020, 12, 14, 16969–16977.en_ZA
dc.identifier.issn1944-8244 (print)
dc.identifier.issn1944-8252 (online)
dc.identifier.other10.1021/acsami.0c02061
dc.identifier.urihttp://hdl.handle.net/2263/81143
dc.language.isoenen_ZA
dc.publisherAmerican Chemical Societyen_ZA
dc.rights© 2020 American Chemical Societyen_ZA
dc.subjectLayered double hydroxide (LDH)en_ZA
dc.subjectCellulose nanofibers (CNF)en_ZA
dc.subjectStearic aciden_ZA
dc.subjectX-ray diffraction (XRD)en_ZA
dc.subjectDynamic mechanical thermal analysis (DMA)en_ZA
dc.subjectDextrinen_ZA
dc.subjectSolid dosage formen_ZA
dc.subjectAcaricideen_ZA
dc.subjectThemoplastic starchen_ZA
dc.titleDextrin nanocomposites as matrices for solid dosage formsen_ZA
dc.typePostprint Articleen_ZA

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