Comparison of MRI, [18F]FDG PET/CT, and 99mTc-UBI 29-41 scintigraphy for postoperative spondylodiscitis—a prospective multicenter study

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dc.contributor.author Paez, Diana
dc.contributor.author Sathekge, Mike Machaba
dc.contributor.author Douis, Hassan
dc.contributor.author Giammarile, Francesco
dc.contributor.author Fatima, Shazia
dc.contributor.author Dhal, Anil
dc.contributor.author Puri, Sunil K.
dc.contributor.author Erba, Paola A.
dc.contributor.author Lazzeri, Elena
dc.contributor.author Ferrando, Rodolfo
dc.contributor.author Filho, Paulo Almeida
dc.contributor.author Magboo, Vincent Peter
dc.contributor.author Morozova, Olga
dc.contributor.author Nunez, Rodolfo
dc.contributor.author Pellet, Olivier
dc.contributor.author Mariani, Giuliano
dc.date.accessioned 2021-05-31T12:51:49Z
dc.date.available 2021-05-31T12:51:49Z
dc.date.issued 2021-06
dc.description.abstract PURPOSE: Postoperative infection still constitutes an important complication of spine surgery, and the optimal imaging modality for diagnosing postoperative spine infection has not yet been established. The aim of this prospective multicenter study was to assess the diagnostic performance of three imaging modalities in patients with suspected postoperative spine infection: MRI, [ 18F]FDG PET/CT, and SPECT/CT with 99mTc-UBI 29-41. METHODS: Patients had to undergo at least 2 out of the 3 imaging modalities investigated. Sixty-three patients enrolled fulfilled such criteria and were included in the final analysis: 15 patients underwent all 3 imaging modalities, while 48 patients underwent at least 2 imaging modalities (MRI + PET/CT, MRI + SPECT/CT, or PET/CT + SPECT/CT). Final diagnosis of postoperative spinal infection was based either on biopsy or on follow-up for at least 6 months. The MRI, PET/CT, and SPECT/CT scans were read blindly by experts at designated core laboratories. Spine surgery included metallic implants in 46/63 patients (73%); postoperative spine infection was diagnosed in 30/63 patients (48%). RESULTS: Significant discriminants between infection and no infection included fever (P = 0.041), discharge at the wound site (P < 0.0001), and elevated CRP (P = 0.042). There was no difference in the frequency of infection between patients who underwent surgery involving spinal implants versus those who did not. The diagnostic performances of MRI and [18F]FDG PET/CT analyzed as independent groups were equivalent, with values of the area under the ROC curve equal to 0.78 (95% CI: 0.64– 0.92) and 0.80 (95% CI: 0.64–0.98), respectively. SPECT/CT with 99mTc-UBI 29-41 yielded either unacceptably low sensitivity (44%) or unacceptably low specificity (41%) when adopting more or less stringent interpretation criteria. The best diagnostic performance was observed when combining the results of MRI with those of [18F]FDG PET/CT, with an area under the ROC curve equal to 0.938 (95% CI: 0.80–1.00). CONCLUSION: [ 18F]FDG PET/CT and MRI both possess equally satisfactory diagnostic performance in patients with suspected postoperative spine infection, the best diagnostic performance being obtained by combining MRI with [18F]FDG PET/CT. The diagnostic performance of SPECT/CT with 99mTc-UBI 29-41 was suboptimal in the postoperative clinical setting explored with the present study. en_ZA
dc.description.department Nuclear Medicine en_ZA
dc.description.librarian pm2021 en_ZA
dc.description.uri http://link.springer.com/journal/259 en_ZA
dc.identifier.citation Paez, D., Sathekge, M.M., Douis, H. et al. Comparison of MRI, [18F]FDG PET/CT, and 99mTc-UBI 29-41 scintigraphy for postoperative spondylodiscitis—a prospective multicenter study. European Journal of Nuclear Medicine and Molecular Imaging 48, 1864–1875 (2021). https://doi.org/10.1007/s00259-020-05109-x. en_ZA
dc.identifier.issn 1619-7070 (print)
dc.identifier.issn 1619-7089 (online)
dc.identifier.other 10.1007/s00259-020-05109-x
dc.identifier.uri http://hdl.handle.net/2263/80171
dc.language.iso en en_ZA
dc.publisher Springer en_ZA
dc.rights © The Author(s) 2020. This article is licensed under a Creative Commons Attribution 4.0 International License. en_ZA
dc.subject Spine surgery en_ZA
dc.subject Postoperative spine infection en_ZA
dc.subject Diagnostic imaging en_ZA
dc.subject Magnetic resonance imaging (MRI) en_ZA
dc.subject [18F]FDG PET/CT en_ZA
dc.subject SPECT/CT with 99mTc-UBI 29-41 en_ZA
dc.title Comparison of MRI, [18F]FDG PET/CT, and 99mTc-UBI 29-41 scintigraphy for postoperative spondylodiscitis—a prospective multicenter study en_ZA
dc.type Article en_ZA


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