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Browsing University of Pretoria: Research Output by UP Author "Ismail, Nazir Ahmed"
Now showing items 1-20 of 68
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Omar, Shaheed Vally; Roth, Andreas; Ismail, Nazir Ahmed; Erasmus, Linda; Ehlers, Marthie Magdaleen; Kock, Marleen M.; Paulse, Nuraan; Said, H.M. (Halima Mohammed); Hoosen, Anwar Ahmed; Reischl, Udo (Public Library of Science, 2011-09-22)BACKGROUND: The LightCyclerH Mycobacterium Detection Kit based on real-time PCR technology for the detection of Mycobacterium tuberculosis, Mycobacterium avium and Mycobacterium kansasii was recently developed. This study ...
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Bamford, Colleen; Bonorchis, Kim; Ryan, Anthea; Simpson, John; Elliott, Eugenne; Hoffmann, Rena; Naicker, Preneshni; Ismail, Nazir Ahmed; Mbelle, Nontombi Marylucy; Nchabeleng, Maphoshane; Nana, Trusha; Sriruttan, Charlotte; Seetharam, Sharona; Wadula, Jeannette (Federation of Infectious Diseases Societies of South Africa, 2011)We report on antimicrobial susceptibility surveillance data for six key bloodstream pathogens (Escherichia coli, Klebsiella pneumoniae, Enterobacter spp., Pseudomonas aeruginosa, Acinetobacter baumannii and Staphylococcus ...
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Ismail, Nazir Ahmed; Omar, Shaheed Vally; Moultrie, Harry; Bhyat, Zaheda; Conradie, Francesca; Enwerem, M.; Ferreira, Hannetjie; Hughes, Jennifer; Joseph, Lavania; Kock, Yulene; Letsaolo, Vancy; Maartens, Gary; Meintjes, Graeme; Ngcamu, Dumisani; Okozi, Nana; Padanilam, Xavier; Reuter, Anja; Romero, Rodolfo; Schaaf, Simon; Te Riele, Julian; Variava, Ebrahim; Van der Meulen, Minty; Ismail, Farzana; Ndjeka, Norbert (Elsevier, 2022-04)BACKGROUND : Bedaquiline improves outcomes of patients with rifampicin-resistant and multidrug-resistant (MDR) tuberculosis; however, emerging resistance threatens this success. We did a cross-sectional and longitudinal ...
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Ndjeka, Norbert; Ismail, Nazir Ahmed (Elsevier, 2021-08)Bedaquiline, a novel therapeutic drug, and clofazimine, a re-purposed drug, are front-line therapies recommended by WHO to treat rifampicin-resistant or multidrugresistant tuberculosis. Both drugs have been in use ...
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Ndjeka, Norbert; Ismail, Nazir Ahmed (Elsevier, 2020-08)Bedaquiline, a novel therapeutic drug, and clofazimine, a re-purposed drug, are front-line therapies recommended by WHO to treat rifampicin-resistant or multidrugresistant tuberculosis. Both drugs have been in use ...
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Ismail, Nazir Ahmed; Ihekweazu, Chikwe; Koornhof, Hendrik; Madhi, Shabir A. (Federation of Infectious Diseases Societies of South Africa, 2012)Tuberculosis (TB) continues to be one of the biggest public health challenges of our time, and as epidemiology of the disease evolves in an era of high HIV prevalence in South Africa, so must the response. With exciting ...
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Ismail, Nabila; Omar, Shaheed Vally; Ismail, Nazir Ahmed; Peters, Remco P.H. (Elsevier, 2018-10)A comprehensive literature search was conducted to obtain previously published resistance associated mutations for bedaquiline, clofazimine and linezolid for Mycobacterium tuberculosis. Where possible, mutation frequencies ...
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Said, Halima Mohammed; Kock, Marleen M.; Ismail, Nazir Ahmed; Baba, Kamaldeen A.; Omar, Shaheed Vally; Osman, Ayman Gassim Elamin; Hoosen, Anwar Ahmed; Ehlers, Marthie Magdaleen (BioMed Central, 2012-12-22)BACKGROUND: The increasing problem of multi-drug-resistant (MDR) tuberculosis (TB) [ie resistant to at least isoniazid (INH) and rifampicin (RIF)] is becoming a global problem. Successful treatment outcome for MDR-TB depends ...
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Rukasha, Ivy; Said, Halima M.; Omar, Shaheed Vally; Koornhof, Hendrik; Dreyer, Andries W.; Musekiwa, Alfred; Moultrie, Harry; Hoosen, Anwar A.; Kaplan, Gilla; Fallows, Dorothy; Ismail, Nazir Ahmed (Frontiers Research Foundation, 2016-12-06)Treatment of tuberculosis (TB) and HIV co-infections is often complicated by drug-to-drug interactions between anti-mycobacterial and anti-retroviral agents. Rifabutin (RFB) is an alternative to rifampin (RIF) for TB ...
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Jha, Swati; Ismail, Nazir Ahmed; Clark, David; Lewis, James J.; Omar, Shaheed Vally; Dreyer, Andries; Chihota, Violet; Churchyard, Gavin; Dowdy, David W. (Public Library of Science, 2016-06-20)BACKGROUND Automated digital microscopy has the potential to improve the diagnosis of tuberculosis (TB), particularly in settings where molecular testing is too expensive to perform routinely. The cost-effectiveness of ...
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Jamieson, Lise; Evans, Denise; Berhanu, Rebecca; Ismail, Nazir Ahmed; Aucock, Samantha; Wallengren, Kristina; Long, Lawrence (BioMed Central, 2019)BACKGROUND : To assess the quality and completeness of treatment and outcome data in the electronic tuberculosis (TB) and antiretroviral treatment (ART) registers in drug-resistant (DR-) TB patients at three treatment ...
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Ismail, Nazir Ahmed; Omar, Shaheed Vally; Joseph, Lavania; Govender, Netricia; Blows, Linsay; Ismail, Farzana; Koornhof, Hendrik; Dreyer, Andries W; Kaniga, Kone; Ndjeka, Norbert (Elsevier, 2018-02)BACKGROUND : Bedaquiline (BDQ) is a novel agent approved for use in combination treatment of multi-drug resistant tuberculosis (MDR-TB).We sought to determine BDQ epidemiological cut-off values (ECVs), define and assess ...
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Said, Halima; Ratabane, John; Erasmus, Linda; Gardee, Yasmin; Omar, Shaheed Vally; Dreyer, Andries; Ismail, Farzana; Bhyat., Zaheda; Lebaka, Tiisetso; Van der Meulen, Minty; Gwala, Thabisile; Adelekan, Adeboye; Diallo, Karidia; Ismail, Nazir Ahmed (BMC, 2021-05)BACKGROUND: Studies have shown that drug-resistant tuberculosis (DR-TB) in South Africa (SA) is clonal and is caused mostly by transmission. Identifying transmission chains is important in controlling DR-TB. This study ...
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Ismail, Nazir Ahmed; Ismail, Farzana; Omar, Shaheed Vally; Blows, Linsay; Gardee, Yasmin; Koornhof, Hendrik; Onyebujoh, Philip C. (AOSIS Open Journals, 2018-12-06)BACKGROUND : The World Health Organization End TB Strategy targets for 2035 are ambitious and drug resistant tuberculosis is an important barrier, particularly in Africa, home to over a billion people. OBJECTIVE : We ...
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Ismail, Nazir Ahmed; Koser, Claudio U.; Javid, Babak; Ellington, Matthew J.; Feveriegel, Silke; Niemann, Stefan; Brown, Nicolas M.; Burman, William J.; Abubakar, Ibrahim; Moore, David; Peacock, Sharon J.; Torok, M.Estee; Liddel, Kathleen (Elsevier, 2015-01)Bedaquiline and delamanid, novel classes of anti-tuberculosis drugs, have been recently approved for the treatment of multidrug-resistant tuberculosis. Antimicrobial resistance invariably follows the introduction of ...
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Ismail, Nazir Ahmed; Dippenaar, Anzaan; Warren, R.M.; Peters, Remco P.H.; Omar, Shaheed V. (American Society for Microbiology, 2023-04)In Mycobacterium tuberculosis, bedaquiline and clofazimine resistance occurs primarily through Rv0678 variants, a gene encoding a repressor protein that regulates mmpS5/mmpL5 efflux pump gene expression. Despite the shared ...
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Ismail, Nazir Ahmed; Ismail, Farzana; Joseph, Lavania; Govender, Netricia; Blows, Linsay; Kaniga, Kone; Omar, Shaheed Vally (Nature Publishing Group, 2020-01-23)Universal drug susceptibility testing (DST) is an important requirement of the End TB Strategy. The Sensititre broth micro-dilution assay (BMD) tests multiple drugs quantitatively. We defined interpretive criteria for ...
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Said, Halima Mohammed; Ismail, Nazir Ahmed; Osman, Ayman Gassim Elamin; Velsman, Chrisna; Hoosen, Anwar Ahmed (American Society for Microbiology, 2011-05)Tuberculosis (TB) is a disease of major public health concern worldwide, especially in developing countries. In addition, the human immunodeficiency virus (HIV) epidemic has increased the incidence of infection ...
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Said, Halima Mohammed; Kock, Marleen M.; Ismail, Nazir Ahmed; Baba, Kamaldeen A.; Omar, Shaheed Vally; Osman, Ayman Gassim Elamin; Hoosen, Anwar Ahmed; Ehlers, Marthie Magdaleen (International Union Against Tuberculosis and Lung Disease, 2012-01)BACKGROUND: The GenoType® MTBDRsl assay (Hains, Lifesciences, Germany) is a new rapid assay for detection of resistance to second-line anti-tuberculosis drugs. METHOD: The MTBDRsl assay was evaluated on 342 MDR-TB isolates ...
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Gardee, Y.; Dreyer, A.W.; Koornhof, H.J.; Omar, Shaheed Vally; Da Silva, P.; Bhyat, Z.; Ismail, Nazir Ahmed (American Society for Microbiology, 2017-03)Early detection of resistance to second-line antituberculosis drugs is important for the management of multidrug-resistant tuberculosis (MDR-TB). The GenoType MTBDRsl version 2.0 (VER 2.0) line probe assay has been redesigned ...
Now showing items 1-20 of 68