Odontogenic tumors and lesions treated in a single specialist oral and maxillofacial pathology unit in the United Kingdom in 1992–2016

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dc.contributor.author Siriwardena, Bogahawatte Samarakoon Mudiyanselage Samadarani
dc.contributor.author Crane, Hannah
dc.contributor.author O'Neill, Niall
dc.contributor.author Abdelkarim, Rasha
dc.contributor.author Brierley, Daniel J.
dc.contributor.author Franklin, Christopher D.
dc.contributor.author Farthing, Paula M.
dc.contributor.author Speight, Paul M.
dc.contributor.author Hunter, K.D. (Keith)
dc.date.accessioned 2018-12-13T06:07:06Z
dc.date.issued 2018-10
dc.description.abstract OBJECTIVES : Odontogenic tumors (ODTs) are a heterogeneous group of lesions derived from elements of tooth-forming tissues. No detailed data on the incidence of odontogenic tumors in the United Kingdom have been published. The aim of this study was to retrospectively describe the range and incidence of odontogenic tumors from 1992 to 2016 in a single specialist unit and to compare this population with others. STUDY DESIGN : By using the Oral and Maxillofacial Pathology database, Sheffield (UK), we included both local and referred consultation cases. A proportion of diagnoses were reclassified in accordance with the 2017 World Health Organization classification. RESULTS : In total, 559 odontogenic tumors were diagnosed. Overall, the most common lesions were ameloblastoma (196 [33.8%]), odontoma (148 [25.5%]), and odontogenic myxoma (37 [6.3%]), but this varied between local and referral case populations, with odontomas being most common in the local population (43%). The sites affected and the gender and age of patients were similar to other Western populations. Malignant ODTs comprised 33 cases (5.7%), of which 9 (27.3%) were ameloblastic carcinoma. The majority of the malignant ODTs comprised referral cases. CONCLUSIONS : Here, we present the first detailed data on ODTs within a UK population, and the pattern of incidence from the local population is similar to other Western populations. The exceptional rarity of malignant ODTs emphasizes the need for specialist centers for their treatment to gain diagnostic experience. STATEMENT OF CLINICAL RELEVANCE : This article presents the first comprehensive data on odontogenic tumors from a UK population, underlining the relative rarity of these lesions and the importance of access to specialist pathology services for diagnosis. en_ZA
dc.description.department Oral Pathology and Oral Biology en_ZA
dc.description.embargo 2019-10-05
dc.description.librarian hj2018 en_ZA
dc.description.uri http://www.journals.elsevier.com/oral-surgery-oral-medicine-oral-pathology-and-oral-radiology en_ZA
dc.identifier.citation Siriwardena, B.S.M.S., Crane, H., O'Neill, N. et al. 2018', Odontogenic tumors and lesions treated in a single specialist oral and maxillofacial pathology unit in the United Kingdom in 1992–2016', Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology, NYP. en_ZA
dc.identifier.issn 2212-4403 (print)
dc.identifier.issn 2212-4411 (online)
dc.identifier.other 10.1016/j.oooo.2018.09.011
dc.identifier.uri http://hdl.handle.net/2263/68096
dc.language.iso en en_ZA
dc.publisher Elsevier en_ZA
dc.rights © 2018 Elsevier Inc. All rights reserved. Notice : this is the author’s version of a work that was accepted for publication in Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. A definitive version was subsequently published in Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology, vol. , no. . pp. , 2018. doi : 10.1016/j.oooo.2018.09.011. en_ZA
dc.subject Odontogenic tumor (ODT) en_ZA
dc.subject Tooth-forming tissues en_ZA
dc.subject United Kingdom (UK) en_ZA
dc.subject Oral and maxillofacial pathology en_ZA
dc.title Odontogenic tumors and lesions treated in a single specialist oral and maxillofacial pathology unit in the United Kingdom in 1992–2016 en_ZA
dc.type Postprint Article en_ZA


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