dc.contributor.author |
Ligthelm, Louis J.
|
|
dc.contributor.author |
Bunn, Belinda Kathleen
|
|
dc.contributor.author |
Raubenheimer, E.J. (Erich)
|
|
dc.contributor.author |
Van Heerden, Willem Francois Petrus
|
|
dc.date.accessioned |
2018-05-24T12:43:48Z |
|
dc.date.issued |
2018-05 |
|
dc.description.abstract |
BACKGROUND : Primary intestinal‐type adenocarcinoma of the tongue is rare. This represents the first reported case of a primary mixed adenoneuroendocrine carcinoma (MANEC) of the tongue arising within a congenital enteric cyst.
METHODS : A 52‐year‐old man presented with a midline tongue mass that was connected to the mucosal surface with an epithelial‐lined sinus tract. orphological examination and immunohistochemical profiling of the neoplasm were performed. RESULTS : Histopathological evaluation showed a primary MANEC arising within a preexisting congenital enteric cyst, comprising both adenocarcinoma and neuroendocrine components. The adenocarcinoma had a colonic‐type morphology and coexpressed CK7, CK20, and CDX2. Imaging and colonoscopy excluded a distant primary colorectal neoplasm. CONCLUSION : The association of primary MANEC of the tongue with a gastrointestinal heterotopic cyst supports an origin from entrapped endodermal elements as opposed to salivary duct origin. This case raises the awareness of a rare yet prognostically important complication of a gastrointestinal heterotopic cyst. |
en_ZA |
dc.description.department |
Oral Pathology and Oral Biology |
en_ZA |
dc.description.embargo |
2019-05-01 |
|
dc.description.librarian |
hj2018 |
en_ZA |
dc.description.uri |
http://wileyonlinelibrary.com/journal/hed |
en_ZA |
dc.identifier.citation |
Ligthelm LJ, Bunn BK, Raubenheimer EJ, Heerden WFP. Mixed adenoneur-oendocrine carcinoma of the tongue arising within a congenital enteric cyst. Head & Neck. 2018;40:E53–E57. https://doi.org/10.1002/hed.25117. |
en_ZA |
dc.identifier.issn |
1043-3074 (print) |
|
dc.identifier.issn |
1097-0347 (online) |
|
dc.identifier.other |
10.1002/hed.25117 |
|
dc.identifier.uri |
http://hdl.handle.net/2263/65009 |
|
dc.language.iso |
en |
en_ZA |
dc.publisher |
Wiley |
en_ZA |
dc.rights |
© 2018 Wiley Periodicals, Inc. This is the pre-peer reviewed version of the following article : Mixed adenoneur-oendocrine carcinoma of the tongue arising within a congenital enteric cyst, Head and Neck, vol. 40, pp. E53–E57, 2018, doi : 10.1002/hed.25117. The definite version is available at : https://http://wileyonlinelibrary.com/journal/hed. |
en_ZA |
dc.subject |
Mixed adenoneuroendocrine carcinoma (MANEC) |
en_ZA |
dc.subject |
Tongue |
en_ZA |
dc.subject |
Congenital enteric cyst |
en_ZA |
dc.subject |
Histogenesis |
en_ZA |
dc.subject |
Rare |
en_ZA |
dc.subject |
Tract |
en_ZA |
dc.subject |
Entity |
en_ZA |
dc.subject |
Gastrointestinal heterotopic cyst |
en_ZA |
dc.subject |
Colonic‐type adenocarcinoma |
en_ZA |
dc.subject |
Primary tongue adenocarcinoma |
en_ZA |
dc.title |
Mixed adenoneuroendocrine carcinoma of the tongue arising within a congenital enteric cyst |
en_ZA |
dc.type |
Postprint Article |
en_ZA |