Ex vivo and In vivo characterization of interpolymeric blend/nanoenabled gastroretentive levodopa delivery systems

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dc.contributor.author Ngwuluka, Ndidi C.
dc.contributor.author Choonara, Yahya E.
dc.contributor.author Modi, Girish
dc.contributor.author Du Toit, Lisa C.
dc.contributor.author Kumar, Pradeep
dc.contributor.author Meyer, L.C.R. (Leith Carl Rodney)
dc.contributor.author Snyman, Tracy
dc.contributor.author Pillay, Viness
dc.date.accessioned 2017-08-03T13:02:22Z
dc.date.available 2017-08-03T13:02:22Z
dc.date.issued 2017
dc.description.abstract One approach for delivery of narrow absorption window drugs is to formulate gastroretentive drug delivery systems. This study was undertaken to provide insight into in vivo performances of two gastroretentive systems (PXLNET and IPB matrices) in comparison to Madopar® HBS capsules. The pig model was used to assess gastric residence time and pharmacokinetic parameters using blood, cerebrospinal fluid (CSF), and urine samples. Histopathology and cytotoxicity testing were also undertaken. The pharmacokinetic parameters indicated that levodopa was liberated from the drug delivery systems, absorbed, widely distributed, metabolized, and excreted. were 372.37, 257.02, and 461.28 ng/mL and MRT were 15.36, 14.98, and 13.30 for Madopar HBS capsules, PXLNET, and IPB, respectively. In addition, X-ray imaging indicated that the gastroretentive systems have the potential to reside in the stomach for 7 hours. There was strong in vitro-in vivo correlation for all formulations with values of 0.906, 0.935, and 0.945 for Madopar HBS capsules, PXLNET, and IPB, respectively. Consequently, PXLNET and IPB matrices have pertinent potential as gastroretentive systems for narrow absorption window drugs (e.g., L-dopa) and, in this application specifically, enhanced the central nervous system and/or systemic bioavailability of such drugs. en_ZA
dc.description.department Paraclinical Sciences en_ZA
dc.description.librarian am2017 en_ZA
dc.description.sponsorship The National Research Foundation (NRF) of South Africa en_ZA
dc.description.uri https://www.hindawi.com/journals/pd en_ZA
dc.identifier.citation Ngwuluka, N.C., Choonara, Y.E., Modi, G., Du Toit, L.C., Kumar, P., Meyer, L.C.R., Snyman, T. & Pillay, V. 2017, 'Ex vivo and In vivo characterization of interpolymeric blend/nanoenabled gastroretentive levodopa delivery systems', Parkinson’s Disease, vol. 2017, art. no. 7818123, pp. 1-14. en_ZA
dc.identifier.issn 2090-8083 (print)
dc.identifier.issn 2042-0080 (online)
dc.identifier.other 10.1155/2017/7818123
dc.identifier.uri http://hdl.handle.net/2263/61573
dc.language.iso en en_ZA
dc.publisher Hindawi Publishing en_ZA
dc.rights © 2017 Ndidi C. Ngwuluka et al. This is an open access article distributed under the Creative Commons Attribution License. en_ZA
dc.subject Drugs en_ZA
dc.subject Delivery systems en_ZA
dc.subject Gastroretentive drug delivery systems en_ZA
dc.subject Gastroretentive systems en_ZA
dc.subject Cerebrospinal fluid (CSF) en_ZA
dc.subject Blood en_ZA
dc.subject Urine en_ZA
dc.subject PXLNET matrices en_ZA
dc.subject IPB matrices en_ZA
dc.title Ex vivo and In vivo characterization of interpolymeric blend/nanoenabled gastroretentive levodopa delivery systems en_ZA
dc.type Article en_ZA


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