Increased risk of suicide in schizophrenia patients with linkage to chromosome 13q

Malherbe, P.J.; Karayiorgou, M.; Ehlers, Rene; Roos, J.L. (Johannes Louw)

dc.contributor.author	Malherbe, P.J.
dc.contributor.author	Karayiorgou, M.
dc.contributor.author	Ehlers, Rene
dc.contributor.author	Roos, J.L. (Johannes Louw)
dc.date.accessioned	2017-03-07T05:28:38Z
dc.date.issued	2017-05
dc.description.abstract	We link schizophrenia in families from the genetically isolated South African Afrikaner population to chromosome 13q (n =51), 1p (n =23) and combined 13q & 1p (n =18). Patients with linkages to chromosome 13q were 4.16 times more likely to meet diagnostic criteria for schizoaffective disorder compared to patients with linkage to 1p. A third of patients with linkage to both 13q & 1p met diagnostic criteria for SAD. There was a significant positive relationship between suicidality and a diagnosis of schizoaffective disorder. Identifying linkage to chromosome 13q may be informative in identifying suicide risk early and prevent morbidity and mortality in schizophrenia patients.	en_ZA
dc.description.department	Psychiatry	en_ZA
dc.description.department	Statistics	en_ZA
dc.description.embargo	2018-05-31
dc.description.librarian	hb2017	en_ZA
dc.description.sponsorship	JL Roos is receiving incentive funding from the National Research Foundation (NRF).	en_ZA
dc.description.uri	http://www.elsevier.com/locate/psychres	en_ZA
dc.identifier.citation	Malherbe, PJ, Karayiorgou, M, Ehlers, R & Roos, JL 2017, 'Increased risk of suicide in schizophrenia patients with linkage to chromosome 13q', Psychiatry Research, vol. 251, pp. 34-35.	en_ZA
dc.identifier.issn	0165-1781 (print)
dc.identifier.issn	1872-7123 (online)
dc.identifier.other	10.1016/j.psychres.2017.02.008
dc.identifier.uri	http://hdl.handle.net/2263/59286
dc.language.iso	en	en_ZA
dc.publisher	Elsevier	en_ZA
dc.rights	© 2017 Elsevier B.V. All rights reserved. Notice : this is the author’s version of a work that was accepted for publication in Psychiatry Research. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. A definitive version was subsequently published in Psychiatry Research, vol. 251, pp. 34-35, 2017. doi : 10.1016/j.psychres.2017.02.008.	en_ZA
dc.subject	Schizoaffective disorder	en_ZA
dc.subject	Linkage to chromosome 13q	en_ZA
dc.subject	Suicide	en_ZA
dc.subject	Schizophrenia (SCZ)	en_ZA
dc.title	Increased risk of suicide in schizophrenia patients with linkage to chromosome 13q	en_ZA
dc.type	Postprint Article	en_ZA