dc.contributor.author |
Khazir, Jabeena
|
|
dc.contributor.author |
Mir, Bilal Ahmad
|
|
dc.contributor.author |
Pilcher, Lynne A.
|
|
dc.contributor.author |
Riley, Darren L.
|
|
dc.contributor.author |
Chashoo, Gousia
|
|
dc.contributor.author |
Islam, Md Ataul
|
|
dc.contributor.author |
Saxena, Ajit K.
|
|
dc.contributor.author |
Kumar, H.M.S. (Halmuthur Mahabalarao Sampath)
|
|
dc.date.accessioned |
2017-03-03T06:22:48Z |
|
dc.date.issued |
2016-09 |
|
dc.description.abstract |
Here we describe ring opening reaction of a novel halo triene derivative viz., (3S, 5aS)-8-
chloro-3a, 4, 5, 5a-tetrahydro-3, 5a, 9-trimethylnaphtho [1, 2-b] furan-2(3H)-one of α-
santonin upon nucleophillic attack with alcohols. Halo-triene was synthesized from α-
santonin upon reaction with vilsmeier reagent. The synthesised compounds from ring opening
reaction were evaluated for anticancer activity against a panel of four human cancer cell lines
(A-549, THP-1, HCT-15, and IMR-13). Most of the compounds exhibited promising
anticancer activity against all cancer cells in vitro; however compound. 3d with benzyl
substitution showed most potent anticancer activity with an IC50 value of 0.3 μM, 0.51 μM,
0.6 μM and 0.23 μM against A-549, THP-1, HCT- 116 and IMR-13 cell lines respectively. |
en_ZA |
dc.description.department |
Chemistry |
en_ZA |
dc.description.department |
Chemical Pathology |
|
dc.description.department |
Genetics |
|
dc.description.embargo |
2017-09-30 |
|
dc.description.librarian |
hb2017 |
en_ZA |
dc.description.uri |
http://link.springer.com/journal/44 |
en_ZA |
dc.identifier.citation |
Khazir, J., Mir, B.A., Pilcher, L.A., Riley, D.L., Gashoo, G., Islam, M.A., Saxena, A.K. & Kumar, H.M.S. Design and synthesis of ring C opened analogues of α-santonin as potential anticancer agents. Medicinal Chemistry Research (2016) 25: 2030-2041. doi:10.1007/s00044-016-1633-8. |
en_ZA |
dc.identifier.issn |
1054-2523 (print) |
|
dc.identifier.issn |
1554-8120 (online) |
|
dc.identifier.other |
10.1007/s00044-016-1633-8 |
|
dc.identifier.uri |
http://hdl.handle.net/2263/59252 |
|
dc.language.iso |
en |
en_ZA |
dc.publisher |
Springer |
en_ZA |
dc.rights |
© Springer Science+Business Media New York 2016. The original publication is available at : http://link.springer.comjournal/44. |
en_ZA |
dc.subject |
α-Santonin |
en_ZA |
dc.subject |
Vilsmeier reaction |
en_ZA |
dc.subject |
Aliphatic alcohols |
en_ZA |
dc.subject |
Cytotoxicity |
en_ZA |
dc.title |
Design and synthesis of ring C opened analogues of α-santonin as potential anticancer agents |
en_ZA |
dc.type |
Postprint Article |
en_ZA |