dc.contributor.author |
Oberholzer, Hester Magdalena
|
|
dc.contributor.author |
Van der Schoor, Ciska
|
|
dc.contributor.author |
Bester, Megan Jean
|
|
dc.date.accessioned |
2016-02-10T11:23:49Z |
|
dc.date.issued |
2015-07 |
|
dc.description.abstract |
Sibutramine hydrochloride monohydrate is a weight loss agent indicated for the treatment of
obesity. Although it has been banned from most markets, studies are still relevant as it is
often a hidden ingredient in herbal and over the counter slimming products. Sibutramine
induces liver fibrosis with steatosis in female Sprague-Dawley rats fed a high-energy diet
without significant weight gain. In this study, using the same animal model, the effect of
Sibutramine on lung morphology was investigated using histological evaluation of the
terminal bronchiole and transmission electron microscopy evaluation of the respiratory
tissue. From these results Sibutramine was found to induce lung fibrosis in Sprague-Dawley
rats as increased collagen synthesis, mast cell accumulation and aggregates of Bronchus
Associated Lymphoid Tissue (BALT) in the terminal bronchiole as well as increased collagen
deposition in the respiratory tissue was seen. |
en_ZA |
dc.description.embargo |
2016-07-31 |
|
dc.description.librarian |
hb2015 |
en_ZA |
dc.description.sponsorship |
National Research Foundation (NRF) |
en_ZA |
dc.description.uri |
http://www.elsevier.com/locate/etap |
en_ZA |
dc.identifier.citation |
Oberholzer, HM, Van der Schoor, C & Bester, MJ 2015, 'Sibutramine, a serotonin-norepinephrine reuptake inhibitor, causes fibrosis in rats', Environmental Toxicology and Pharmacology, vol. 40, no. 1, pp. 71-76. |
en_ZA |
dc.identifier.issn |
1382-6689 (print) |
|
dc.identifier.issn |
1872-7077 (online) |
|
dc.identifier.other |
10.1016/j.etap.2015.05.011 |
|
dc.identifier.uri |
http://hdl.handle.net/2263/51319 |
|
dc.language.iso |
en |
en_ZA |
dc.publisher |
Elsevier |
en_ZA |
dc.rights |
© 2015 Elsevier B.V. All rights reserved. All rights reserved. Notice : this is the author’s version of a work that was accepted for publication in Environmental Toxicology and Pharmacology. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in Environmental Toxicology and Pharmacology, vol. 40, no.1, pp. 71-76, 2015. doi :10.1016/j.etap.2015.05.011. |
en_ZA |
dc.subject |
Sibutramine |
en_ZA |
dc.subject |
Fibrosis |
en_ZA |
dc.subject |
Mast cells |
en_ZA |
dc.subject |
iBALT |
en_ZA |
dc.subject |
Collagen |
en_ZA |
dc.subject |
Bronchus Associated Lymphoid Tissue (BALT) |
en_ZA |
dc.subject.other |
Health sciences article SDG-03 |
|
dc.subject.other |
SDG-03: Good health and well-being |
|
dc.subject.other |
Health sciences article SDG-12 |
|
dc.subject.other |
SDG-12: Responsible consumption and production |
|
dc.title |
Sibutramine, a serotonin-norepinephrine reuptake inhibitor, causes fibrosis in rats |
en_ZA |
dc.type |
Postprint Article |
en_ZA |