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Synthesis, structural characterization and antimycobacterial evaluation of several halogenated non-nitro benzothiazinones

Madikizela, Balungile; Eckhardt, Tamira; Goddard, Richard; Richter, Adrian; Lins, Anika; Lehmann, Christoph; Imming, Peter; Seidel, Rudiger W. (Springer, 2021-08)

8-Nitro-1,3-benzothiazin-4-ones (BTZs), with BTZ043 and PBTZ169 as the most advanced compounds, represent a new class of potent antitubercular agents, which irreversibly inhibit decaprenylphosphoryl-β-D-ribose-2′-epimerase ...

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