Browsing Workspace (UPSpace) by Author "Birkholtz, Lyn-Marie"

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Antimalarial and antitumour activities of the steroidal quinone-methide celastrol and its combinations with artemiside, artemisone and methylene blue

Ng, Jerome P.L.; Han, Yu; Yang, Li Jun; Birkholtz, Lyn-Marie; Coertzen, Dina; Wong, Ho Ning; Haynes, Richard K.; Wong, Vincent Kam Wai (Frontiers Media S.A., 2022-09-02)

Artemisinin, isolated from the traditional Chinese medicinal plant qīng hāo 青蒿 (Artemisia annua) and its derivatives are used for treatment of malaria. With treatment failures now being recorded for the derivatives and ...
Histone modification landscapes as a roadmap for malaria parasite development

Connacher, Jessica I.; Von Gruning, Hilde; Birkholtz, Lyn-Marie (Frontiers Media S.A., 2022-04-01)

Plasmodium falciparum remains the deadliest parasite species in the world, responsible for 229 million cases of human malaria in 2019. The ability of the P. falciparum parasite to progress through multiple life cycle ...
MALBoost : a web‑based application for gene regulatory network analysis in Plasmodium falciparum

Van Wyk, Roelof Daniel Jacobus; Van Biljon, Riette; Birkholtz, Lyn-Marie (BioMed Central, 2021-07-14)

BACKGROUND : Gene Regulatory Networks (GRN) produce powerful insights into transcriptional regulation in cells. The power of GRNs has been underutilized in malaria research. The Arboreto library was incorporated into a ...

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