Browsing Workspace (UPSpace) by Author "Van den Bout, Iman"

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Continual proteomic divergence of HepG2 cells as a consequence of long-term spheroid culture

Ellero, Andrea Antonio; Van den Bout, Iman; Vlok, Mare; Cromarty, Allan Duncan; Hurrell, Tracey (Nature Research, 2021-05)

Three-dimensional models are considered a powerful tool for improving the concordance between in vitro and in vivo phenotypes. However, the duration of spheroid culture may infuence the degree of correlation between these ...
Functional rescue of inactivating mutations of the human neurokinin 3 receptor using pharmacological chaperones

Anderson, Ross Calley; Hanyroup, Sharika; Song, Yong Bhum; Mohamed-Moosa, Zulfiah; Van den Bout, Iman; Schwulst, Alexis C.; Kaiser, Ursula B.; Millar, Robert P.; Newton, Claire L. (MDPI, 2022-04-21)

G protein-coupled receptors (GPCRs) facilitate the majority of signal transductions across cell membranes in humans, with numerous diseases attributed to inactivating GPCR mutations. Many of these mutations result in ...

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